Navigation Links
Better cholesterol drugs may follow Saint Louis University researcher's breakthrough
Date:10/5/2010

ST. LOUIS Thanks to a discovery by a Saint Louis University researcher, scientists have identified an important microRNA that may allow us to better control cholesterol levels in blood.

Led by ngel Baldn, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University and published in a recent issue of Proceedings of the National Academy of Sciences of the United States of America, the study found that the microRNA miR-33, may be key to controlling HDL, or "good" cholesterol levels.

In the U.S., heart attack, stroke, and peripheral artery disease collectively account for more than 30 percent of all deaths in the last decade. Atherosclerosis, the fatty build-up in arteries that causes these illnesses, is tied to cholesterol levels, a waxy substance found in the blood.

Statins, drugs frequently prescribed by doctors to manage cholesterol levels, work by lowering LDL, or "bad" cholesterol levels; however, their role in HDL cholesterol is still obscure. Importantly, HDL has been found to have a protective benefit against cardiovascular disease.

"Atherosclerosis costs lives and takes an enormous toll on our health," said Baldn. "If the discovery that miR-33 can be used to raise HDL levels leads to better medications, it will have an enormous impact on our ability to treat heart disease."

The study, which was funded by the National Institutes of Health, Saint Louis University Center for Cardiovascular Research and the Doisy Department of Biochemistry and Molecular Biology at Saint Louis University, examined SREBP-2, an important gene in the body, and zeroed in on the microRNA miR-33, which is expressed within SREBP-2.

Increasing the levels of miR-33 in the liver, scientists discovered, resulted in lower HDL cholesterol levels in an animal model; conversely, turning off miR-33, researchers found, had the effect of raising HDL levels.

Paralleling these results, four separate studies reported similar findings, adding to investigators' hope that better medications may be on the horizon for managing atherosclerosis. Scientists hope that future medications may prove to be more effective than statins alone by not only lowering LDL-cholesterol levels, but also increasing HDL levels.


'/>"/>

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert

Related medicine news :

1. Doctors need to help patients prepare better for health decisions
2. Microbiomes may hold key to better understanding of preterm birth
3. Friends, family detect early Alzheimers signs better than traditional tests
4. Better marker for breast cancer may reduce need for second surgeries
5. Prostate cancer community calls for better early detection and treatment
6. What can health-care facilities do to help patients better understand medical information
7. Centralized health care more cost-effective, offers better access to preventive services
8. University of Colorado Denver Business School study shows failure better teacher than success
9. Drug addicts get hooked via prescriptions, keep using to feel like a better person, research shows
10. Moderate drinking, especially wine, associated with better cognitive function
11. Better understanding of mapmaking in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
Breaking Medicine Technology: