Navigation Links
Better MRI scans of cancers made possible by TU Delft
Date:1/13/2009

Researcher Kristina Djanashvili has developed a substance that enables doctors to get better MRI scans of tumours. On Tuesday 13 January, Djanashvili will be awarded a doctorate by TU Delft for her work in this field.

The medical profession's ability to trace and visualise tumours is increasing all the time. Detection and imaging techniques have improved enormously in recent years. One of the techniques that have come on by leaps and bounds is MRI. Patients who are going to have MRI scans are often injected with a 'contrast agent', which makes it easier to distinguish tumours from surrounding tissues. The quality of the resulting scan depends partly on the ability of this agent to 'search out' the tumour and induce contrast.

Better images

At TU Delft, postgraduate researcher Kristina Djanashvili has developed a new contrast agent with enhanced tumour affinity and contrast induction characteristics. In principle, this means that cancers can be picked up sooner and visualised more accurately.

The new agent is a compound incorporating a lanthanide chelate and a phenylboronate group substance. The lanthanide chelate ensures a strong, clear MRI signal, while the phenylboronate group substance 'searches out' cancerous tissue.

Water exchange

The lanthanide chelate influences the behaviour of water molecules, even inside the human body. It is ultimately the behaviour of the hydrogen nuclei in the water molecules that makes MRI possible and determines the quality of the image produced. The stronger the influence of the lanthanide chelate on the neighbouring hydrogen nuclei (the so-called water exchange) and the more hydrogen nuclei affected, the better the MRI signal obtained. Djanashvili has defined the methods for determining the water exchange parameters.

Sugar

Djanashvili has also provided her contrast agent with enhanced tumour-seeking properties by including a phenylboronate group substance. Phenylboronate has an affinity with certain sugary molecules that tend to concentrate on the surface of tumour cells. What makes the selected phenylboronate-containing agent special is its ability to chemically bond with the surface of a tumour cell.

Mice

Finally, Djanashvili has managed to incorporate the compound into so-called thermosensitive liposomes. A thermosensitive liposome forms a sort of protective ball, which opens (releasing the active compound) only when heated to roughly 42 degrees. This means that, by localised heating of a particular part of the body, it is possible to control where the compound is released. The positive results obtained from testing the new agent on mice open the way for further research.


'/>"/>

Contact: Frank Nuijens, science information officer
f.w.nuijens@tudelft.nl
31-152-784-259
Delft University of Technology
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
3. Informational handout key to giving parents a better understanding of CT radiation risks
4. Children of depressed moms do better when dad is involved, SLU researcher finds
5. Struggling male readers respond better to female teachers
6. Physician Skin Care Specialist Says Proposed New Rules for Sunscreen Products Will Better Protect the Public
7. Mothers Know Best: NFL Moms Team With Eddie George to Showcase a Better Way to a Healthier Lifestyle
8. Researchers Find Better Way to Deliver Blood Thinner
9. Clinical trials present better alternatives for dialysis patients
10. New nurses report job stress, need for better management
11. Hispanics hypertension better controlled with equal access to care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Robins & ... in Durant, Oklahoma, on Feb. 21. , The celebration began with a ribbon ... clinic employees, the construction team and tribal leadership. , Choctaw Nation Durant ...
(Date:2/21/2017)... ... ... Individuals who have been diagnosed with cancer are at ... management. Regular exercise in proper environments has been shown to benefit these patients, ... 23, 2017, 1:00-2:00 p.m. E.S.T., a dynamic HydroWorx webinar led by ...
(Date:2/21/2017)... ... February 21, 2017 , ... Each ... Black History Month (officially African American History Month ). This ... society of a diverse race of people, but also the opportunity to examine ...
(Date:2/21/2017)... ... February 21, 2017 , ... CLICKco LLC, a company dedicated ... are now available for purchase on RonnieColemanNutrition.com, a popular website for health and ... health-conscious consumers who love coffee but are looking to add more protein to ...
(Date:2/20/2017)... Raton, FL (PRWEB) , ... February 20, 2017 ... ... creating a patent-pending probiotic supplement that supports the proper levels of “good” bacteria ... purchase on StackedNutrition.com, a popular nutritional products website. , Daily Body Restore® ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... 21, 2017 Cognitive Computing for Cancer ... allowing a previously unattainable level of personalized treatment ... ability, it is anticipated that the Global Cancer ... by 2022. The growth of the market is ... platforms, rising installation of cognitive computing software in ...
(Date:2/21/2017)... 2017 Sangamo Therapeutics, Inc. (Nasdaq: SGMO), the ... company will release its fourth quarter and full year ... February 28, 2017. The press release will be followed ... will be open to the public via telephone and ... its financial results and provide a business update. ...
(Date:2/21/2017)... Feb. 21, 2017  International Isotopes Inc. (OTCQB: INIS) ... placement with certain investors for approximately $3.4 million of ... Series C Convertible Redeemable Preferred Stock (the "Series C ... annual rate of 6% and is convertible into common ... use the proceeds for operating capital, to pay off ...
Breaking Medicine Technology: