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Beta Blocker May Shrink Infant Hemangiomas
Date:6/11/2008

e given. The most common treatment for more serious hemangiomas is corticosteroids. Other medications that can be used include vincristine (a chemotherapy medication) and interferon.

Propranolol is a blood pressure-lowering medication from a class of medications called beta blockers. Beta blockers aren't advised for people with asthma, diabetes or a known heart blockage, according to Leaute-Labreze. She said none of the infants had serious side effects from propranolol, though some experienced low blood pressure.

Because all of the currently used medications have side effects, some serious, Gehris said the idea that propranolol could be used is an "enticing, interesting idea, because we're always looking for safer and more effective treatments."

But, she added, this study was done on a very small number of children, and it wasn't placebo-controlled. Additionally, in at least some of the cases, infants had already been given steroids, so, Gehris said, it's possible the reaction attributed to propranolol might have been a delayed reaction to the steroids.

Leaute-Labreze said that the researchers plan on conducting further research to further assess propranolol's effect on hemangiomas, and the authors of the study have applied for a patent on the use of beta blockers for the treatment of infant hemangioma.

"Propranolol may constitute a reasonable, safe alternative to systemic corticosteroids, and even to interferon or vincristine in severe infant hemangioma. However, the risk/benefit ratio of this treatment should be evaluated in non-alarming, cosmetically impairing infant hemangiomas," Leaute-Labreze said.

More information

To learn more about hemangiomas, visit the U.S. National Library of Medicine.



SOURCES: Christine Leaute-Labreze, M.D., department of pediatric d
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Beta Blocker May Shrink Infant Hemangiomas
Beta Blocker May Shrink Infant Hemangiomas
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