Navigation Links
Beta Blocker May Shrink Infant Hemangiomas
Date:6/11/2008

Blood pressure drug reduced color, size of disfiguring vessel growths, researcher says

WEDNESDAY, June 11 (HealthDay News) -- New research suggests that a blood pressure medication can shrink abnormal and sometimes disfiguring growths of blood vessels in infants known as hemangiomas.

When using propranolol to treat heart conditions in two infants who also had a hemangioma, French researchers noticed that the color and size of the hemangioma was reduced within a day for both babies.

"We have serendipitously observed that propranolol can inhibit the growth phase of infant hemangioma in two consecutive infants," said Dr. Christine Leaute-Labreze, from the department of pediatric dermatology at Bordeaux Children's Hospital in France.

"After informed consent was obtained from the parents, propranolol was given to nine additional patients who had severe or disfiguring infant hemangiomas. In all cases, 24 hours after the onset of treatment, we observed a change in color from intense red to purple, associated with a palpable softening of the lesion," she said.

Results of the study were published as a letter in the June 12 issue of the New England Journal of Medicine.

Hemangiomas, commonly seen as red lesions, are usually found in the top layers of the skin, but sometimes, they grow much deeper. Although they're noncancerous, they can be disfiguring.

Most hemangiomas grow for about nine months, according to Dr. Robin Gehris, chief of pediatric dermatologic surgery at Children's Hospital of Pittsburgh. "Their natural history is that they behave similar to placental tissue. They actively proliferate for about nine months, then stabilize, and then [decrease] about 10 percent a year until they're gone," she said, adding that without treatment most are gone by the time a child is 10.

If a hemangioma is growing near the eye, mouth or airway, Gehris said that treatment will often be given. The most common treatment for more serious hemangiomas is corticosteroids. Other medications that can be used include vincristine (a chemotherapy medication) and interferon.

Propranolol is a blood pressure-lowering medication from a class of medications called beta blockers. Beta blockers aren't advised for people with asthma, diabetes or a known heart blockage, according to Leaute-Labreze. She said none of the infants had serious side effects from propranolol, though some experienced low blood pressure.

Because all of the currently used medications have side effects, some serious, Gehris said the idea that propranolol could be used is an "enticing, interesting idea, because we're always looking for safer and more effective treatments."

But, she added, this study was done on a very small number of children, and it wasn't placebo-controlled. Additionally, in at least some of the cases, infants had already been given steroids, so, Gehris said, it's possible the reaction attributed to propranolol might have been a delayed reaction to the steroids.

Leaute-Labreze said that the researchers plan on conducting further research to further assess propranolol's effect on hemangiomas, and the authors of the study have applied for a patent on the use of beta blockers for the treatment of infant hemangioma.

"Propranolol may constitute a reasonable, safe alternative to systemic corticosteroids, and even to interferon or vincristine in severe infant hemangioma. However, the risk/benefit ratio of this treatment should be evaluated in non-alarming, cosmetically impairing infant hemangiomas," Leaute-Labreze said.

More information

To learn more about hemangiomas, visit the U.S. National Library of Medicine.



SOURCES: Christine Leaute-Labreze, M.D., department of pediatric dermatology, Bordeaux Children's Hospital, and The National Center for Rare Skin Disorders of Bordeaux, France; Robin Gehris, chief, pediatric dermatologic surgery, Children's Hospital of Pittsburgh; June 12, 2008, New England Journal of Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Beta Blocker Doesnt Help Children With Heart Failure
2. Blood-vessel blocker aids cancer-killing virus
3. FDA approves Bystolic, a novel beta blocker
4. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
5. Venture Global Limited Introduces an Innovative Anti-Cellphone Radiation Sticker Named VEGO Power Blocker
6. Women are treated less frequently than men with statins, aspirin and beta-blockers
7. Study Shows Increased Out-of-Pocket Expenses May Negatively Influence Initiation of TNF Blocker Therapy
8. Beta Blockers Raise Stroke, Death Risk After Surgery
9. Shrinkage of prostate led to overestimation of cancer risk in trial
10. Aging heart changes shape, shrinks and loses pumping function too
11. Drug combination shrinks breast cancer metastases in brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Beta Blocker May Shrink Infant Hemangiomas
(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/25/2017)... Sept. 25, 2017  EpiVax, Inc., a leader ... and immune-engineering today announced the launch of EpiVax ... of personalized therapeutic cancer vaccines. EpiVax has provided ... access to enabling technologies to the new precision ... lead EpiVax Oncology as Chief Executive Officer. Gad ...
Breaking Medicine Technology: