Navigation Links
Beta Blocker Doesn't Help Children With Heart Failure
Date:9/11/2007

Trial shows no improvement with carvedilol

TUESDAY, Sept. 11 (HealthDay News) -- Carvedilol, a newer member of the beta blocker drug family that has been effective for adults with heart failure, did not help children with the condition, a new study found.

The rate of improvement -- and the lack of it -- was almost exactly the same for 103 young heart-failure patients given the drug as it was for 54 youngsters who got a placebo.

"Heart failure in children is both not common and a different kind of disease" than in adults, said Dr. Robert E. Shaddy, division chief of cardiology at Children's Hospital of Philadelphia, and lead author of the report.

Adults suffer heart failure, a progressive loss of the heart's ability to pump blood, because of coronary artery disease, Shaddy said. "Children rarely get it," he said. "In them, it is caused either by heart muscle problems or problems related to congenital malformations."

Among the 103 young people assigned to carvedilol, 56 percent improved, 19 percent were unchanged, and 24 percent worsened. Among the 54 who got conventional treatment and a placebo, 56 percent improved, 30 percent worsened, and 15 percent were unchanged.

The study findings are published in the Sept. 12 issue of the Journal of the American Medical Association.

It's still possible that the drug, which is marketed as Coreg, might help some children with heart failure, Shaddy said. An analysis of subgroups of patients in the study did show some improvement for children whose problem rested in the left ventricle, he said. "What I recommend to families based on this study is that there might possibly be a differential effect, which depends on the type of heart problem. But we were unable to prove it," he added.

Much larger studies would be needed to prove such a benefit in pediatric heart failure, and such studies would be hard to do, because the condition is rare, Shaddy said.

Dr. Samuel S. Gidding, an attending cardiologist at the Nemours Cardiac Center in Wilmington, Del., who wrote an accompanying editorial in the journal, said, "This study was underpowered [small in numbers] to show a benefit. The causes of heart failure in children are very different from the causes of heart failure in adults. Also, the drug is metabolized more quickly in children, so some patients are under-dosed, and there is a different response to drugs based on the disease class."

The study shows the hazards of extrapolating treatment results in adults to children, Gidding said. "We would need to be a lot more aggressive in trials in children to show what works and what doesn't work," he said. "We need much bigger clinical trials in kids rather than imposing conclusions from adult trials."

If further studies are to be done, Shaddy said, "we would recommend that they be done with a more homogeneous group, children with one type of heart disease."

"Children are not little adults," Gidding added. "In adulthood, there is a lot more wear and tear on the body."

More information

You can learn more about beta-blocker drugs from the Texas Heart Institute.



SOURCES: Robert E. Shaddy, M.D., chief, division of cardiology, Children's Hospital of Philadelphia; Samuel S. Gidding, M.D., attending cardiologist, Nemours Cardiac Center, Wilmington, Del.; Sept. 12, 2007, Journal of the American Medical Association


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Angiotensin-II-receptor blockers - Treat kidney failure
2. Calcium-blocker delays atherosclerosis than beta-blockers
3. Evidence against use of Beta blockers as first choice in the treatment of primary hypertension
4. Beta-Blockers Should Be the Second Line of Treatment
5. Alpha-blockers call for modification in cataract surgery
6. Beta-Blockers Should Not Be First Choice for High Blood Pressure
7. Drinking Real Juice Doesnt Cause Obesity In Children
8. Anti-smoking Ads at the Movies Doesnt Make Any Impact on Smokers
9. Fruit Juice Doesnt Cause Overweight in Kids
10. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
11. Inhaled Steroids Safe & Effective for Children with Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... TX (PRWEB) , ... February 27, 2017 , ... ... 75,000 customer threshold mark last week. In addition, Discount Power's RCE (Residential Customer ... Energy LLC in March 2014. The company had 800 customers and 2,250 RCEs ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley Hair ... announce a new informational post on robotic hair transplantation. San Francisco residents may ... transplant and Follicular Unit Transplantation (FUT) can sound similar. Either treatment can be ...
(Date:2/27/2017)... ... ... New Jersey ranks among the top five states in the entire nation ... advanced services is growing. , Project WE vs C is a focused two-year ... non-profit partners in their fight against cancer and in support of their shared mission ...
(Date:2/26/2017)... Como, Italy (PRWEB) , ... February 26, 2017 ... ... its last call for entries to the 7th Edition of International Social Design ... by Social Design Professionals, Product Designers, System Designers, Governments and Institutions worldwide with ...
(Date:2/26/2017)... ... February 26, 2017 , ... NuevaCare, a leading home care agency based in ... Palo Alto, is proud to announce an important upgrade to its geographic information pages, ... care close to home, and by having city-specific pages, NuevaCare is answering that information ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017  Today, exocad America and the Biodenta ... new path to produce 510(K) cleared, in-house milled, ... integrated into exocad DentalCAD software. In order to ... Manufacturing Processes (GMP,s) into their organization, sign up ... an audit process. Then, dental labs can use Biodenta,s ...
(Date:2/24/2017)... Research and Markets has announced the addition of ... to 2025" report to their offering. ... The Global Empty Capsules Market is poised to grow ... approximately $2.9 billion by 2025. This industry report analyzes ... as well as regional levels presented in the research scope. The study ...
(Date:2/24/2017)... Feb. 24, 2017  In conjunction with DURECT Corporation,s ... results press release, you are invited to listen to ... the internet on Tuesday, March 14, 2017 at 4:30 ... A live audio webcast of the presentation will be ... and clicking "Investor Relations."  If you are unable to ...
Breaking Medicine Technology: