Navigation Links
Best drug development results from computer/test tube combination
Date:10/4/2010

While computer simulations of how the body metabolises drugs save both time and money, the best results when developing new drugs come from combining such simulations with laboratory experiments, reveals a researcher from the University of Gothenburg.

"My research demonstrates the benefits of combining traditional laboratory experiments with computer-based calculation models to understand and explain how the body's various enzymes interact with a drug when breaking it down," says Britta Bonn from the University of Gothenburg's Department of Chemistry. "It can really help when developing and designing molecules with the desired metabolic characteristics for a new drug."

When developing new drugs, it is important to understand how they will be broken down in the body, and which products are formed during this process. This breakdown of foreign substances is known as metabolism, and can be viewed as the conversion of the drug to a non-toxic, water-soluble product that can easily leave the body, in urine for example.

Enzymes does the job

Drug metabolism is the work of catalysts known as enzymes, and generally takes place in the liver. If a drug is broken down too effectively, it may not have the desired effect, and toxic metabolic products may form. It is therefore important to study and understand how drugs are broken down.

Traditionally laboratory experiments have been used to study drug/enzyme interactions, for example in cell-based systems in test tubes (in vitro). Recent years have also brought major progress in computer-based models (in silico) and information on the enzymes' 3D structures.

Combines in vitro and in silico

Britta Bonn has focused on two important enzymes from the CYP family, which are the most common drug-metabolising enzymes, both in vitro and in silico to understand how they interact with foreign substances.

"My studies aimed to find out things
'/>"/>

Contact: Britta Bonn
kjelland@chem.gu.se
46-707-913-657
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
2. Elderly might not benefit from TB vaccines in development
3. Childrens brain development is linked to physical fitness
4. Brain Scans Could Spot Developmental Problems in Kids
5. Study finds that cancer-causing gene crucial in stem cell development
6. Researchers closer to development of drug to prevent deadly immune response
7. Are early testing and drug development the most pressing issues in Alzheimers care?
8. Merlin protein found to control liver stem cells, prevent tumor development
9. Snake venom studies yield insights for development of therapies for heart disease and cancer
10. Developmental disabilities center established at Washington University
11. Researchers cut years from drug development with nanoscopic bead technology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Best drug development results from computer/test tube combination
(Date:9/21/2014)... 21, 2014 C8 lawsuits move forward ... as the list of 20 possible C8 lawsuits ... to six, reports Wright & Schulte LLC. Court records ... almost 2500 C8 lawsuits filed that represent individuals who ... as a result of being exposed to water contaminated ...
(Date:9/20/2014)... (PRWEB) September 21, 2014 Recently, iFitDress.com, a ... selection of beautiful party dresses . In addition, the ... the main aim of the promotion is to benefit all ... outfits in its online store now. , Along with ... of graceful items. It has recently released its new sexy ...
(Date:9/20/2014)... 2014 Weight Destroyer , a ... expert Michael Wren that has already helped tens of ... health conditions like high blood pressure, high cholesterol, and ... prompting an investigative review. , “Weight Destroyer is ... down by showing people what is truly effective when ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 The Villa ... Villa del Palmar Cabo San Lucas, Villa La Estancia ... to Hurricane Odile, with plans to welcome guests back ... As of Sept. 19, all members and guests of ... thanks to a coordinated effort with government authorities. ...
(Date:9/20/2014)... September 20, 2014 Ticket Down ... tickets . This popular ticket exchange is offering their ... , The 2015 schedule of tours is beginning to fill ... announced their plans to hit the road, including 21-year-old pop ... announced the “Honeymoon Tour,” which will take her to 25 ...
Breaking Medicine News(10 mins):Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 3Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 4Health News:Beautiful Party Dresses For Autumn Unveiled By iFitDress.com 2Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 2Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 3Health News:Villa Group Resorts in Cabo Largely Unharmed, Plan to Re-open Early October 2Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 2Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 3
... Permanente has,announced the promotion of Greg Cleary ... as director, Membership,Administration. He joined Kaiser Permanente ... is responsible for overseeing Kaiser Permanente,s,Membership Administration ... Texas. These,locations include more than 800 employees ...
... 15 IDEXX Laboratories,Inc. (Nasdaq: IDXX ), announced ... by the Company of an additional four million,shares of ... will be made in the open market or in ... shares remaining as of,December 31, 2007, under a previous ...
... found, health officials still recommend inoculation , , FRIDAY, Feb. ... in virtually every state, and many of the infections ... this year,s influenza vaccine, U.S. health officials said Friday. ... in the early part of the season, since January, ...
... for TRIA, the first hair removal ... U.S. home-based beauty device market, NEW YORK, Feb. ... Communications as its U.S. agency of record for,TRIA, the ... beauty,device market., SpectraGenics, Inc. is a leader in ...
... leading global,provider of clinical documentation technology and services, ... board of directors., Tsai is a principal ... Co., one of the world,s largest private equity ... hold the,majority ownership of Spheris., Tsai,s election ...
... Beck Says: ,Barack Will Change America, WASHINGTON, ... service workers endorsed Sen. Barack Obama for,president today, ... best plan,and best strategy to lead the country ... the Service Employees International Union endorsed Obama to,achieve ...
Cached Medicine News:Health News:Greg Cleary Named Vice President, Membership Administration for Kaiser Permanente 2Health News:Flu Widespread in U.S., but Vaccine Is Poor Match 2Health News:Spectragenics Names Rpr Marketing Communications Agency of Record 2Health News:Spheris Elects New Board Member 2Health News:SEIU Members Endorse Sen. Barack Obama 2
(Date:9/19/2014)... SOUTH EASTON, Mass. , Sept. 19, 2014 ... the "Company") today announced it has received and ... throughput Barozyme HT48 instruments and has begun to ... believes the first instrument will be ready for ... will be built and released at a rate ...
(Date:9/19/2014)... , September 19, 2014 ... IQ den äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, der jetzt ... interaktive PDF, verfügbar unter pharmaserialisation.com , zeigt ... sie jeweils in Kraft treten. Für ... nicht länger um das "ob", sondern darum, "wann" ...
(Date:9/19/2014)... CAMBRIDGE, Mass. , Sept. 19, 2014 ... a provider of advanced cancer genome analysis and ... leader in discovering and developing highly selective kinase ... first-ever comprehensive genomic study of malignant mixed Mullerian ... the female reproductive system, also known as carcinosarcoma. ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
... Delivers Unprecedented Specificity for ... Diagnosing ... Medical Solutions,Diagnostics (http://www.siemens.com/diagnostics ) announced that it has ... rights to develop an,automated stimulating TSH receptor antibody (TRAb) ...
... more effective than,tamoxifen at preventing breast cancer recurrence ... with hormone-responsive cancers. In addition, the increased,risk of ... being treated with,anastrozole disappears after treatment ends., ... Antonio Breast Cancer,Symposium, Professor John Forbes of the ...
Cached Medicine Technology:Siemens Medical Solutions Diagnostics Inks Agreement with KreLo Medical Diagnostics to Expand Thyroid Immunoassay Menu 2Siemens Medical Solutions Diagnostics Inks Agreement with KreLo Medical Diagnostics to Expand Thyroid Immunoassay Menu 3Anastrozole Confirmed Superior in Breast Cancer Prevention 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: