Navigation Links
Berkeley Lab scientists find that normal breast cells help kill cancer cells
Date:4/13/2011

ab colleague of Bissell's.

"Even healthy individuals produce genetically impaired cells at the rate of up to 1,000 aberrant cells per day, however, as a part of homeostatic regulations, these cancer-prone cells are efficiently eradicated by the so- called tumor surveillance system of our body," Furuta says. "A number of tumor surveillance mechanisms have been described in the past, including the classic molecular tumor suppressors, immune surveillance, and suppression by the extracellular matrix and other microenvironmental factors. We are now adding a new type of tumor suppression to this list, IL25 and other proteins secreted by normal breast cells that kill or subdue their mutated neighbors."

In their study, Furuta, Bissell, Lee and their colleagues found that whereas IL25 was highly toxic to breast cancer cells, it did not harm normal breast cells. The selectivity, they discovered, is due to the presence of an abundance of exposed IL25 receptors on breast cancer cells. These IL25 receptors were absent on normal breast cells.

"Since IL25 is produced by healthy breast tissue as a natural defense mechanism against cancer during the cell differentiation process, we should be able to utilize IL25/IL25 receptor signaling as an organic approach to breast cancer therapy," Furuta says.

Normal epithelial cells, in cooperation with the microenvironment that surrounds them, actively help maintain the health and integrity of tissue. They do this in part by regulating the secretion of cell signaling factors both autocrine and paracrine - that promote the development of healthy organs and prevent the aberrant growth of neighboring cells. In previous studies, Furuta and collaborators have shown that conditioned-medium, taken from normal mammary epithelial cells while in the process of forming acini in a 3D lamin-rich extracellular matrix culture, can "revert" the malignant phenotype of breast cancer cells so that they behave as
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. UCSF, UC Berkeley join forces to advance frontier of brain repair
2. Conference highlights UC Berkeleys unique approach to green chemistry
3. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
4. Berkeley study shows ozone and nicotine a bad combination for asthma
5. UC Berkeley psychologists bring science of happiness to China
6. Lawrence Berkeley National Laboratory and OpenHelixTM Announce an Updated Free Tutorial Suite for VISTA: Tools for Comparative Genomics
7. Artery Plaque Forms in Short Time Span, Scientists Say
8. Scientists Complete Detailed Map of Human Brain
9. Feinstein scientists identify abnormal disease pathway in dystonia
10. Scientists find potential benefit of hypericin for recurrent brain tumors
11. Scientists Use Computer to Read Human Thoughts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Berkeley Lab scientists find that normal breast cells help kill cancer cells
(Date:7/3/2015)... (PRWEB) , ... July 03, ... ... announced the sessions and speaker lineup for its 2015 Annual Conference ... place August 6-8, 2015 at the Renaissance Orlando at SeaWorld in Orlando, ...
(Date:7/3/2015)... ... 03, 2015 , ... The Erie County Bar Association Institute ... The Association welcomed speaker C. Daniel McGillicuddy Esq. of William Mattar Law Offices. ... investigating these types of cases. , Each year, New York State residents are ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ” was featured ... coolest technology products available to consumers. Amanda Forstrom, a technology expert and special reporter ... great for documenting memories. , Almost every smartphone has an incredibly powerful camera built ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce ... sweetFrog store located in the Lone Star State. The premium frozen yogurt chain was listed ... store, which opened June 19 in the Village at Bachman Lake, is located at:, 3701 ...
(Date:7/2/2015)... ... , ... Many Fourth of July celebrations will include fireworks this summer, so ... sharing some tips to promote the proper use of fireworks. , According to the ... daily with fireworks-related injuries in the month surrounding the Fourth of July. Amica is ...
Breaking Medicine News(10 mins):Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 3Health News:Attorney from William Mattar Leads Discussion on Bicycle Accidents 2Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:6 Fireworks Safety Tips from Amica Insurance 2
... study suggests, , WEDNESDAY, Jan. 20 (HealthDay News) -- ... drills, say German researchers. , They found that firing ... tooth structure beneath the enamel coating -- reduced the ... results suggest that plasma jets could be used to ...
... ... , ... MD (Vocus) January 20, 2010 -- Healthy Directions, LLC, is proud to announce ... top quality natural solutions to today’s most pressing health concerns. The new Web ...
... CHICAGO , Jan. 20 According to ... American Journal of Health Promotion , a peer-reviewed journal devoted ... activities within an incentive-based health insurance wellness program had significantly ... data over one year of 948,974 adult members of ...
... benefit patients, survey reports , WEDNESDAY, Jan. 20 (HealthDay ... medical students think that knowledge of complementary and alternative ... , Complementary and alternative medicine, or CAM, includes ... , "Even with the high prevalence of CAM use ...
... ... decisions are substantiated by accurate data analysis and reporting, four colleges within the ... , ... NH (PRWEB) January 20, 2010 -- In today’s technology-driven environment, where sound business ...
... ... On January 2 of this year, Freedom From Covert Harassment and Surveillance ... This event coincides with January as National Stalking Awareness Month. Organized ... may not even know why the stalking is occurring, has emerged with ...
Cached Medicine News:Health News:Healthy Directions, LLC, Announces Launch of Online Resource for Premium Quality Natural Health Solutions 2Health News:Research Indicates Participants in Incentive-Based Health Promotion Programs Have Lower Healthcare Costs 2Health News:Research Indicates Participants in Incentive-Based Health Promotion Programs Have Lower Healthcare Costs 3Health News:Research Indicates Participants in Incentive-Based Health Promotion Programs Have Lower Healthcare Costs 4Health News:New Hampshire Community Colleges Choose Rapid Insight for Data Reporting Needs 2Health News:FFCHS Launches Online Petition Against Organized Stalking and Electronic Torture 2Health News:FFCHS Launches Online Petition Against Organized Stalking and Electronic Torture 3Health News:FFCHS Launches Online Petition Against Organized Stalking and Electronic Torture 4
(Date:7/2/2015)...   Decision Resources Group finds that ... frequent dosing as the highest unmet need in ... on both patients and providers associated with monthly ... which are the current standard of care. The ... in development for dosing every two to three ...
(Date:7/2/2015)... , July 2, 2015  Konica Minolta, Inc. (Konica ... that it has acquired Sawae Technologica Ltda., an X-ray ... Brazil , through its Brazilian healthcare sales company, ... Local Brazil market ... increasing population exceeding 200 million, significant healthcare technical advancements ...
(Date:7/2/2015)... Ill. , July 2, 2015  AbbVie (NYSE: ... results on Friday, July 24, 2015, before the market ... of the earnings conference call at 8 a.m. Central ... AbbVie,s Investor Relations website at www.abbvieinvestor.com . An ... 11 a.m. Central time. About AbbVie ...
Breaking Medicine Technology:Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 3Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 2Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 3
... treated with Satraplatin Demonstrated Statistically,Significant Improvement in ... March 22, 2007 /PRNewswire-FirstCall/ -- Pharmion,Corporation and ... from,the double-blind, randomized satraplatin Phase 3 registrational,trial, ... Cancer) which were presented today at the ...
... Scientists,at WEHI have made a discovery with potentially ... undergoing,cancer chemotherapy. , The research team led by ... platelet life span is controlled by two key,molecules. ... new,drug to prolong the life span of platelets ...
Cached Medicine Technology:Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 2Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 3Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 4Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 5Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 6Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 7Major Discovery Raises Prospect of Better Patient Care By Improving,Platelet Life Span 2Major Discovery Raises Prospect of Better Patient Care By Improving,Platelet Life Span 3
... VACOPED is a revolutionary cast replacement system ... lower leg and foot. , ,A ... anatomy and in conjunction with a rigid ... general time of fracture or rupture healing ...
... therapeutic benefits of controlled compression and cold, ... pain. The anatomically designed cuff provides complete ... be ordered as a single cuff, or ... and insulation disk). The Cooler is available ...
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
Qualcare™ Thumb Spica...
Medicine Products: