Navigation Links
Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts
Date:7/20/2011

Johns Hopkins scientists have developed a gene-based test to distinguish harmless from precancerous pancreatic cysts. The test may eventually help some patients avoid needless surgery to remove the harmless variety. A report on the development is published in the July 20 issue of Science Translational Medicine.

The investigators estimate that fluid-filled cysts are identified in more than a million patients each year, most of whom have undergone CT or MRI scans to evaluate non-specific symptoms, such as abdominal pain and swelling.

Bert Vogelstein, M.D., co-director of the Ludwig Center at Johns Hopkins and a Howard Hughes Medical Institute investigator, and his colleagues analyzed precancerous cysts from 19 patients and searched for mutations in 169 cancer-causing genes. They found mutations in the KRAS gene, well-known for its prevalence in pancreatic cancers, and the GNAS gene, which had not previously been associated with pancreatic cancer. In both KRAS and GNAS, the mutations occur at a single coding spot in the DNA, the equivalent of a typo in a word within an entire encyclopedia. KRAS and GNAS genes produce signaling proteins, relaying signals from the cell surface to areas within the cell.

The researchers then tested a total of 132 precancerous pancreatic cysts for mutations in KRAS and GNAS. GNAS mutations were found in more than half of the samples (87 of them), and KRAS mutations occurred in 107 samples. Nearly all (127) had mutations in GNAS, KRAS or both. The mutations occurred in large and small, high- and low-grade cysts, and in all major types of the most common precancerous pancreatic cysts. There were no major differences in age, gender or smoking history for people with GNAS or KRAS mutations in their cysts' cells.

Finally, the investigators tested tissue from pancreatic cancers that had developed in eight people with GNAS-mutated cysts. Seven of the eight had GNAS mutations in their
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medical Institutions
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Brain Surgery for Mary Tyler Moore to Remove Benign Tumor
2. Research finds surgery outperforms drug therapy in treatment of benign prostatic hyperplasia
3. Hormone test predicts ovarian function after chemotherapy for breast cancer
4. Earlier PSA Test Best Predicts Risk of Dying From Prostate Cancer: Study
5. VCU Massey Cancer Center finds new biomarker that predicts breast cancer relapse
6. Gene expression predicts chemotherapy sensitivity of triple-negative breast cancer
7. Climate change analysis predicts increased fatalities from heat waves
8. HIV rate in SF could be cut sharply with expanded treatment, study predicts
9. New lung cancer staging system (TNM 7) better predicts local/regional recurrence, study shows
10. Interest in toys predicts effectiveness of autism treatment in toddlers
11. New online tool predicts probability of death from stroke
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts
(Date:4/19/2015)... Houston, Texas (PRWEB) April 19, 2015 ... is pleased to announce the publication of white paper ... Online Affair . As online media provides a ... whole new niche market specifically targeting adulterous spouses ... which an affair becomes as easy as shopping online. ...
(Date:4/18/2015)... York, NY (PRWEB) April 19, 2015 ... experienced strong growth during the past five years. The ... individuals who are unable to fully care for themselves, ... the growing need for dementia care for seniors with ... to rise at an annualized rate of 4.1% to ...
(Date:4/18/2015)... "I recognized the need for a better way ... inventor from Cincinnati, Ohio. "This need inspired me to ... Slyde Door to offer an alternative to the conventional ... convenient storage space for an evacuation stretcher. The door ... , This offers added peace of mind to ...
(Date:4/18/2015)... 18, 2015 Lower-auto-insurance.com has released a ... auto insurance quotes . , Drivers can ... comparing quotes. A professional insurance brokerage website can help ... in a simple, convenient way. The whole process is ... , Comparing online car insurance quotes is advantageous ...
(Date:4/18/2015)... 2015 On April 14th, 2015, Symantec released ... which they say, “exposes a tactical shift by cyberattackers.” With ... were introduced in 2014 - almost a million a day ... to be identified and patched by prominent manufacturers – as ... doing business in a digital world can be fraught with ...
Breaking Medicine News(10 mins):Health News:McCann Investigations Publishes White Paper Married, but Dating: The Rise of the Married Online Affair 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5
... findings of a recent study researchers say that a diet ... cheese, yogurt and fortified orange juice can actually help women ... ,Studies in the past have shown that calcium has ... that when calcium is combined with enough vitamin D, it ...
... processed meat can increase your chance of having colorectal ... the National Cancer Institute. ,Colon and rectum together ... cancer is also called colorectal cancer. Cancer of the ... malignant cells within the lining of colon or rectum. ...
... scared of going to the dentists, but did you know that ... way you feel scared about dental appointments? ,A new study ... are 2.5 times as likely to be afraid of dentists than ... admit it less. ,In the first ever nation wide study ...
... After revolutionizing the treatment of male impotence latest research ... a fatal lung disease walk further and breathe easier. ... condition in which blood pressure is extremely high in ... of the lung’s small blood vessels and if left ...
... to find out why the diabetes drug thiazolidinediones (TZDs) can ... found that the drug TZDs activates a receptor in kidney ... the collecting duct of the kidney. The activation of the ... causes edema. ,TZD drugs are generally used to lower ...
... the Archives of Internal Medicine high intake of calcium// and ... Previous studies have shown that blood calcium and vitamin D ... during the reproductive age of a women, is a ... in a significant number of women for up to two ...
Cached Medicine News:
(Date:4/16/2015)... April 16, 2015 Mallinckrodt plc (NYSE: ... today announced that it has completed its acquisition ... approximately $2.3 billion. The Ikaria acquisition extends Mallinckrodt,s ... reach into neonatal critical care with INOMAX ® ... for a highly vulnerable patient population. It also ...
(Date:4/16/2015)... Mich. , April 16, 2015  Diplomat Pharmacy, ... Shannon Beltrand to their senior leadership team ... will be responsible for securing and properly monitoring Diplomat,s ... secure both internally and externally. Additionally, she will play ... "We are very excited to have ...
(Date:4/16/2015)... YORK , April 16, 2015 An ... additional way to generate trimers from the major HIV ... could benefit future clinical development of HIV vaccine candidates ... the critical target on the surface of HIV for ... an important platform for AIDS vaccine discovery, says ...
Breaking Medicine Technology:Mallinckrodt Completes Acquisition Of Ikaria 2Mallinckrodt Completes Acquisition Of Ikaria 3Mallinckrodt Completes Acquisition Of Ikaria 4Mallinckrodt Completes Acquisition Of Ikaria 5Diplomat Names Shannon M. Beltrand as New CISO 2New Method Holds Promise for HIV Vaccine Development 2
... 8 For more than 10 years, Mark Wentland, professor ... , led a Rensselaer team in the discovery of a ... treat nervous system disorders and addiction. The family of compounds ... lead product candidate from the library. Clinical trials with the ...
... Olmesartan Medoxomil Prevents Onset of Early Kidney Disease in Type ... blood pressure (BP) reduction data from the ongoing landmark study ... A nd D iabetes M icro A lbuminuria ... of Hypertension (ASH) Twenty-Fourth Annual Scientific Meeting and Exposition (ASH ...
Cached Medicine Technology:One Step Closer: Novel Opioid Receptor Compound in Phase I Clinical Trials 2One Step Closer: Novel Opioid Receptor Compound in Phase I Clinical Trials 3One Step Closer: Novel Opioid Receptor Compound in Phase I Clinical Trials 4One Step Closer: Novel Opioid Receptor Compound in Phase I Clinical Trials 5One Step Closer: Novel Opioid Receptor Compound in Phase I Clinical Trials 6Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results 2Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results 3Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results 4Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results 5Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results 6Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results 7
... VersaPulse PowerSuite holmium laser combines excellent ... precise, virtually bloodless procedures. It is ... and gall bladder stones of all ... surgical tool. Because its laser light ...
... VersaPulse PowerSuite holmium laser combines excellent ... precise, virtually bloodless procedures. It is ... and gall bladder stones of all ... surgical tool. Because its laser light ...
... to quickly deliver up to 250 millijoules ... powerful single-pulse ablation. This type of high-energy ... and cleanest CO2 surgical laser available today. ... the independent adjustment of pulse energy and ...
... for perfecting mini-invasive endoscopic methods for ensuring ... a considerable social impact. The use of ... times and represents a valid backup in ... structures.,DEKAs family of Nd:YAG lasers is growing, ...
Medicine Products: