Navigation Links
Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts
Date:7/20/2011

Johns Hopkins scientists have developed a gene-based test to distinguish harmless from precancerous pancreatic cysts. The test may eventually help some patients avoid needless surgery to remove the harmless variety. A report on the development is published in the July 20 issue of Science Translational Medicine.

The investigators estimate that fluid-filled cysts are identified in more than a million patients each year, most of whom have undergone CT or MRI scans to evaluate non-specific symptoms, such as abdominal pain and swelling.

Bert Vogelstein, M.D., co-director of the Ludwig Center at Johns Hopkins and a Howard Hughes Medical Institute investigator, and his colleagues analyzed precancerous cysts from 19 patients and searched for mutations in 169 cancer-causing genes. They found mutations in the KRAS gene, well-known for its prevalence in pancreatic cancers, and the GNAS gene, which had not previously been associated with pancreatic cancer. In both KRAS and GNAS, the mutations occur at a single coding spot in the DNA, the equivalent of a typo in a word within an entire encyclopedia. KRAS and GNAS genes produce signaling proteins, relaying signals from the cell surface to areas within the cell.

The researchers then tested a total of 132 precancerous pancreatic cysts for mutations in KRAS and GNAS. GNAS mutations were found in more than half of the samples (87 of them), and KRAS mutations occurred in 107 samples. Nearly all (127) had mutations in GNAS, KRAS or both. The mutations occurred in large and small, high- and low-grade cysts, and in all major types of the most common precancerous pancreatic cysts. There were no major differences in age, gender or smoking history for people with GNAS or KRAS mutations in their cysts' cells.

Finally, the investigators tested tissue from pancreatic cancers that had developed in eight people with GNAS-mutated cysts. Seven of the eight had GNAS mutations in their
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medical Institutions
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Brain Surgery for Mary Tyler Moore to Remove Benign Tumor
2. Research finds surgery outperforms drug therapy in treatment of benign prostatic hyperplasia
3. Hormone test predicts ovarian function after chemotherapy for breast cancer
4. Earlier PSA Test Best Predicts Risk of Dying From Prostate Cancer: Study
5. VCU Massey Cancer Center finds new biomarker that predicts breast cancer relapse
6. Gene expression predicts chemotherapy sensitivity of triple-negative breast cancer
7. Climate change analysis predicts increased fatalities from heat waves
8. HIV rate in SF could be cut sharply with expanded treatment, study predicts
9. New lung cancer staging system (TNM 7) better predicts local/regional recurrence, study shows
10. Interest in toys predicts effectiveness of autism treatment in toddlers
11. New online tool predicts probability of death from stroke
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts
(Date:8/27/2015)... ... August 27, 2015 , ... Healthpointe is proud to welcome ... Clinic in Los Angeles. Licensed to practice Chinese Needle Therapy since 1983, Dr. Priebe ... and diseases. Dr. Priebe also practices in Healthpointe’s La Mirada clinic and Garden Grove ...
(Date:8/27/2015)... JOHNSON CITY, Tenn. (PRWEB) , ... August 27, 2015 , ... ... Technology LLC, DBA All Clear System. The agreement will enable both Johnson City, Tenn.-based ... , All Clear System is a cloud-based safety product that caters to organizations in ...
(Date:8/27/2015)... ... 2015 , ... Florida Hospital North Pinellas, located at 1395 South Pinellas Avenue in Tarpon Springs, ... new facility will be located at US Highway 19 North and Highlands Boulevard, less than ... and work on the project is slated to begin in September 2015. , ...
(Date:8/27/2015)... ... August 27, 2015 , ... Since its launch on ... having twelve offices in three counties, LA, Orange and San Bernardino. Their ... Founded by Dr. Richy Agajanian, the Oncology Institute of Hope and Innovation ...
(Date:8/27/2015)... PITTSBURGH, PA (PRWEB) , ... August 27, 2015 , ... ... of the shower and tub," said an inventor from Camp Hill, Pa. "I developed ... He created a prototype for the BATH AND SHOWER GRIP to provide a helping ...
Breaking Medicine News(10 mins):Health News:Qualified Medical Examiner and Acupuncturist Joins Healthpointe in Los Angeles 2Health News:Qualified Medical Examiner and Acupuncturist Joins Healthpointe in Los Angeles 3Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 2Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 3Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 4Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 2Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 3Health News:California’s Largest Private Oncology Practice Serves 50,000 Patients in 8 years 2Health News:Inventor and InventHelp Client Develops Bathroom Stabilization Aid (LCC-432) 2
... You,re visiting the dentist for what you think is a ... need a root canal. Though it,s a term you,ve probably ... you may have several questions and feel apprehensive about your ... quite some time. The Pennsylvania Dental Association (PDA) wants to ...
... Healthcare is an industry faced with unprecedented uncertainty. ... overcome the noise and clearly communicate relevant and timely ... company Griffin York & Krause (GY&K) reaffirmed its commitment ... been honored with six national CardioVascular Advertising (CVA) Awards. ...
... New GREENGUARD product certification pilot significantly expands ... exposure to harmful chemicals from products used in ... The GREENGUARD Environmental Institute (GEI) announces the launch ... program incorporating existing stringent indoor air quality criteria, ...
... -- Mesa Laboratories, Inc. (Nasdaq: MLAB ) today ... quarterly dividend of $.11 per share of common stock, up ... be payable December 15, 2009, to shareholders of record on ... Labs has maintained strong cash positions and has continued to ...
... 12 Christiana Care Health System,s Helen ... in the nation to submit specimens to the Biospecimen ... Project. The project is part of a sweeping initiative ... diagnose, treat and even prevent cancer in the future. ...
... muscular dystrophy, experts say , THURSDAY, Nov. 12 (HealthDay ... into the leg muscles of monkeys helped the animals ... , The Muscular Dystrophy Association, which funded the research, ... to better treatment for people who suffer from muscle ...
Cached Medicine News:Health News:Painful Root Canals Are a Thing of the Past 2Health News:Healthcare Organizations Face Tough Marketing Challenges - GY&K Asks 'Are You Relevant?' 2Health News:Healthcare Organizations Face Tough Marketing Challenges - GY&K Asks 'Are You Relevant?' 3Health News:GREENGUARD Launches Comprehensive Health-Based Certification Pilot Program 2Health News:Christiana Care First Community Hospital to Submit Samples to Cancer Genome Atlas Project 2
(Date:8/27/2015)... -- According to a new market research ... by Deployment Mode (Web based, On-Premise, Cloud-Based), by End ... by Component - Global Trends & Forecast to 2019", ... $501.1 Million 2014, and is projected to reach $722.7 ... 2014 to 2019. Browse 60 T ...
(Date:8/27/2015)... The nation,s newest Actos trial gets underway Thursday, August 27 ... courtroom.  Attorneys representing two southern Nevada ... after using the diabetes drug Actos. "Takeda Pharmaceuticals ... that their drug Actos caused an increased risk of bladder ... hold Takeda responsible it is appropriate to seek substantial punitive ...
(Date:8/27/2015)... 2015  BioElectronics Corporation (OTC Pink: BIEL), the maker ... abstracts featuring the use of ActiPatch®, its novel musculoskeletal ... Congress of the European Pain Federation EFIC®, ... 2015. The Company will also be exhibiting at the ... Bagnato , department clinical and experimental rheumatology from the ...
Breaking Medicine Technology:Radiology Information Systems Market Worth $722.7 Million by 2019 2Radiology Information Systems Market Worth $722.7 Million by 2019 3Radiology Information Systems Market Worth $722.7 Million by 2019 42 Billion Dollar Verdict Sought In Actos Trial 2BioElectronics Selected to Present its Pain Research and Devices at the European Pain Federation Conference 2
... YORK, Oct. 18, 2011 Reportlinker.com announces ... available in its catalogue: ... to 2020 http://www.reportlinker.com/p0657234/Cervarix-Cervical-Cancer---Analysis-and-Forecasts-to-2020.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... Analysis and Forecasts to 2020 ...
... Reportlinker.com announces that a new market research ... Orthopedic Biomaterials, The World Market ... products, which can be organic or synthetic in ... fracture to facilitate healing or to compensate for ...
Cached Medicine Technology:Cervarix (Cervical Cancer) - Analysis and Forecasts to 2020 2Cervarix (Cervical Cancer) - Analysis and Forecasts to 2020 3Cervarix (Cervical Cancer) - Analysis and Forecasts to 2020 4Orthopedic Biomaterials, The World Market 2Orthopedic Biomaterials, The World Market 3Orthopedic Biomaterials, The World Market 4
... The Infinity Uric Acid single liquid ... the convenience of single liquid stability ... operator error and provide quick result ... the Infinity Uric Acid reagent provides ...
... The Infinity Glucose Oxidase single ... all the convenience of single liquid ... minimize operator error and provide quick ... of the Infinity Glucose Oxidase reagent ...
... single liquid stable reagent offers the ... liquid stability to help maximize laboratory ... quick result turnaround time. The proprietary ... provides a long shelf life that ...
... the profitability of your practice by seeing more ... VELO system you can turn a 14-18 patients ... day practice. By streamlining automated test sequences, youll ... technology is simple to learn; making it easy ...
Medicine Products: