Navigation Links
Benefits outweigh risks associated with newborn screening for disorder
Date:2/1/2010

Newborn screening for a metabolic disorder could lead to false positives -- adding stress to parents, costing money and possibly subjecting a baby to unnecessary follow-up treatment and dietary restrictions.

But the benefits of diagnosing these children early and preventing the risk of mental retardation, disability or death outweigh the costs of a false positive, according to new U-M research published today in the February issue of the journal Pediatrics.

"Published studies of expanded newborn screening in a U.S. setting have resulted in favorable cost-effective ratios for screening for this illness but did not include primary data for quality of life effects for a false positive screen," says Lisa Prosser, Ph.D., Research Associate Professor in the Division of General Pediatrics at the University of Michigan Health System and the study's lead author. "Our results show that newborn screening remains cost-effective after accounting for the measured loss in quality of life associated with a false positive screen."

The metabolic disorder commonly referred to as MCADD or medium chain acyl-CoA dehydrogenase deficiency -- shows up in one of 15,000 newborns.

When the MCAD enzyme is not working or missing, the body cannot use certain types of fat for energy. This can lead to low blood sugar, or hypoglycemia, and the build-up of harmful substances in the blood. While MCADD patients are usually healthy, repeated episodes of metabolic crisis can cause permanent brain damage. This may result in learning problems and mental retardation.

Researchers used a computer model that took into account costs of screening, including the initial screen test, parent time and medical costs of follow-up testing, treatment and the quality of life implications of having dietary restrictions.

They found that screening requires substantial investment of resources but in exchange for important health benefits. The costs of newborn screening for the illness amounted to $21,000 for every quality-adjusted life year that was gained. A quality-adjusted life year can be thought of as representing a year in perfect health.

"The cost-effectiveness of newborn screening for MCADD is comparable to cost-effectiveness for other childhood interventions, such as vaccinations," Prosser says.

As the number of screened conditions increases, the number of false positives and associated costs also increase, along with the possible identification and treatment of children who may not have experienced related medical problems in the absence of screening, she adds.

"Newborn screening for MCADD remains cost-effective even when the loss in quality of life associated with false positives or dietary treatments are taken into account," Prosser concludes.


'/>"/>

Contact: Margarita Bauza-Wagerson
mbauza@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Original Sewing & Quilt Expo Boosts Benefits
2. State Teachers Retirement System of Ohio Goes Live on V3 Benefits Administration System
3. Machinists Union Leaders Vote to Oppose Health Benefits Tax
4. Quitline messages that stress benefits of quitting may improve smoking cessation
5. The Pill Offers Benefits Beyond Birth Control
6. The Garlands of Barrington Earns International Recognition, Residents Reap the Benefits of Award-Winning EngAGE Lifestyle
7. Jersey Boys' Premiere Benefits Cancer Patients While Launching Beaumont Hospitals Fundraising Campaign
8. Hallmark Insights' Employer Survey Reveals Cost-Savings Benefits of Health & Wellness Programs
9. Physicians Health Choice Receives Senior Choice Gold Award for 2010 Medicare Plan Benefits
10. University of Utah Announces New Studies on the Benefits of Treadmill Desks
11. New National Study Spotlights Importance of Federal Medicare Funding to Propping-Up Seniors Deteriorating State Medicaid Benefits and Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... agency serving communities in the greater Dallas, Miami, and Raleigh regions, is organizing ... fighting to overcome a rare and deadly chromosome abnormality. , After struggling since ...
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), ... call and webcast on Friday, November 3, 2017, beginning ... ending at approximately 8:30 a.m. (CDT) / 9:30 a.m. ... 2017 financial performance and guidance for 2018, Hill-Rom executives ... enhance operational performance, and long-range financial outlook through 2020. ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. ... ...
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
Breaking Medicine Technology: