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Benefits outweigh risks associated with newborn screening for disorder
Date:2/1/2010

Newborn screening for a metabolic disorder could lead to false positives -- adding stress to parents, costing money and possibly subjecting a baby to unnecessary follow-up treatment and dietary restrictions.

But the benefits of diagnosing these children early and preventing the risk of mental retardation, disability or death outweigh the costs of a false positive, according to new U-M research published today in the February issue of the journal Pediatrics.

"Published studies of expanded newborn screening in a U.S. setting have resulted in favorable cost-effective ratios for screening for this illness but did not include primary data for quality of life effects for a false positive screen," says Lisa Prosser, Ph.D., Research Associate Professor in the Division of General Pediatrics at the University of Michigan Health System and the study's lead author. "Our results show that newborn screening remains cost-effective after accounting for the measured loss in quality of life associated with a false positive screen."

The metabolic disorder commonly referred to as MCADD or medium chain acyl-CoA dehydrogenase deficiency -- shows up in one of 15,000 newborns.

When the MCAD enzyme is not working or missing, the body cannot use certain types of fat for energy. This can lead to low blood sugar, or hypoglycemia, and the build-up of harmful substances in the blood. While MCADD patients are usually healthy, repeated episodes of metabolic crisis can cause permanent brain damage. This may result in learning problems and mental retardation.

Researchers used a computer model that took into account costs of screening, including the initial screen test, parent time and medical costs of follow-up testing, treatment and the quality of life implications of having dietary restrictions.

They found that screening requires substantial investment of resources but in exchange for important health benefits. The costs of newborn
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Contact: Margarita Bauza-Wagerson
mbauza@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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