Navigation Links
Benefits of statin therapy may extend beyond lowering lipids
Date:1/4/2012

er an injury, such as cutting your finger. However, it is expressed at high levels under certain abnormal conditions, such as inside atherosclerotic plaques, and gets turned on in a special subset of blood cells called monocytes. Mackman wondered if this was the cause for the abnormal clotting seen in patients with high cholesterol.

To test his hypothesis, Mackman and his colleagues analyzed humans, monkeys and mice with high cholesterol. They found that all three groups have elevated levels of tissue factor in the circulation. Then the researchers treated the mice and monkeys with simvastatin, a drug widely used to treat high blood cholesterol levels. They showed that simvastatin reduced levels of oxidized low density lipoprotein and circulating tissue factor which normalized coagulation without altering plasma cholesterol levels.

These results suggest that oxidized low density lipoproteins induce tissue factor expression on monocytes and this contributes to formation of an occlusive thrombus after plaque rupture.

"Though statin therapy is primarily prescribed to lower cholesterol, some added benefits are its anti-inflammatory and antithrombotic activities," said Mackman. "In terms of drug development, I think we should be trying to better understand the antithrombotic activities of statins so we can develop safer antithrombotic drugs that target the expression of inducible tissue factor."


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. The benefits of cardiac resynchronisation therapy in heart failure
2. Publicly releasing inspection data on meat processing facilities could have substantial benefits
3. Does Psoriasis Thwart the Benefits of Good Cholesterol?
4. Kessler Foundation reports benefits of behavioral technique for cognitive rehabilitation in MS
5. Cooking Class Benefits Kids in Many Ways
6. Quality of life benefits of transcatheter aortic valve replacement differ by access site
7. Benefits of nut consumption for people with abdominal obesity, high blood sugar, high blood pressure
8. Increased use of bikes for commuting offers economic, health benefits
9. Glaucoma Experts Eye Benefits of Exercise
10. Religious, spiritual support benefits men and women facing chronic illness, MU study finds
11. USDA research demonstrates new breeds of broccoli remain packed with health benefits
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Benefits of statin therapy may extend beyond lowering lipids
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... Have you ever wondered what “Karma” really ... you hear the word “Karma.” , Vedic tradition, which gave birth to Hinduism, is ... one of the central concepts of this tradition. According to the wisdom of this heritage, ...
(Date:8/1/2015)... ... ... Brig and Lita Hart, icons of the network marketing industry and founders of ... the HOPE Movement of EvolvHealth. In what has been a long-term relationship between the ... their missions of purpose together to change the course of the network marketing industry. ...
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe ... the very first small business donation to kick off the campaign for healing and ... Her legacy includes a complete line of raw, organic hair care products, as well ...
(Date:7/31/2015)... Vegas, NV (PRWEB) , ... July 31, 2015 , ... Ticket Down is a reputable ... Vegas at the MGM Grand Garden Arena. Fans of every genre of music will ... Friday, September 18th, the first day of the festival, the following artists will perform: ...
(Date:7/31/2015)... ... 31, 2015 , ... Ticket Down is a reliable source for authentic tickets ... Grant Park. The festival will end on Sunday, August 2nd. , ... annual Lollapalooza. This unique and unbelievably popular festival attracts the best in entertainment ...
Breaking Medicine News(10 mins):Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:March4thforWellBeing Foundation Kickoff 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2
... Complimentary Continuing Medical Education Virtual Lecture and Podcast ... Clostridium difficile infection (CDI) is changing ... more severe and complicated disease. Furthermore, the epidemic ... number of states across the United States, and ...
... Corporation (NYSE: CVS ) today announced ... Officer and Chief Administrative Officer, will be making ... Institutional Investors Conference on March 10, 2009. Mr. ... a.m. EDT. (Logo: http://www.newscom.com/cgi-bin/prnh/20090226/NE75914LOGO )An ...
... Supplement Offers Promising Results for Tired Baby ... Ribose Company(TM)--has announced preliminary findings indicating that ... The results were presented at the Scripps ... and is a patented functional ingredient for ...
... Diabetes patients undergoing team-based care do not save ... than other patients, but they are healthier, according ... a substantial financial burden on patients, payers and ... and administration, Penn State, and lead author of ...
... new article appearing in the March 2009 issue of ... ) may lead to improvements in the efficacy of ... researchers discovered a new role for type I interferon, ... to stimulate an immune response against the bacterium known ...
... It might one day be used as an ingredient in ... Past studies have suggested that caffeine might offer some protection ... "We have found what we believe to be the mechanism ... lead researcher Dr. Paul Nghiem, an associate professor of dermatology ...
Cached Medicine News:Health News:Interview with GI Experts: Discussions in Clostridium difficile 2Health News:CVS Caremark Corporation to Present at the Raymond James Institutional Investors Conference on March 10th 2Health News:Bioenergy Ribose Found to Improve Vitality, Aerobic Fitness and Mental Outlook 2Health News:Bioenergy Ribose Found to Improve Vitality, Aerobic Fitness and Mental Outlook 3Health News:Team-based diabetes care fetches more value for dollar 2Health News:New discovery gives tuberculosis vaccine a shot in the arm 2Health News:Caffeine May Offer Some Skin Cancer Protection 2Health News:Caffeine May Offer Some Skin Cancer Protection 3
(Date:7/31/2015)... -- According to a new market research ... (BIA), Dual-Energy X-ray Absorptiometry (DEXA), Skinfold Calipers, Air Displacement ... Forecast to 2019", published by MarketsandMarkets, the global Body ... and is estimated to grow to $1,425.7 Million by ... to 2019. Browse 41 market data ...
(Date:7/30/2015)... , July 30, 2015 IRIDEX Corporation (NASDAQ: ... its second quarter 2015 financial results after the market ... conjunction with the release, the Company will host a ... p.m. Eastern Time on Thursday, August 6, ... and other business developments. Interested parties may ...
(Date:7/30/2015)... , July 30, 2015  Unichem Pharmaceuticals ( ... lot of Hydrochlorothiazide tablets 25 mg 1000-count bottle to ... a precautionary measure due to the identification of a ... The risk associated with mistakenly taking ... the increased probability of experiencing Clopidogrel,s side effects which ...
Breaking Medicine Technology:Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
... /PRNewswire-Asia/ -- Bristol-Myers Squibb Company (NYSE: ... (NYSE: SCR ), a leading pharmaceutical company ... the strategic partnership formed last year to include a ... agreed to co-develop BMS-795311, Bristol-Myers Squibb,s preclinical small molecule ...
... SAN DIEGO, Dec. 13, 2011  BioMed Realty Trust, Inc. ... has entered into a definitive agreement to acquire Prudential ... Street properties.  BioMed previously acquired a 20% interest in ... venture entered into between BioMed and PREI.  The Rogers ...
Cached Medicine Technology:Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 2Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 3Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 4Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 2Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 3Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: