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Benefits of radionuclide therapy for neuroendocrine tumors
Date:9/20/2011

the last treatment cycle and biannually thereafter. In addition to imaging scans and blood work, patients also completed the European Organisation for Research and Treatment of Cancer quality of life questionnairewhich measures levels of fatigue, nausea plus vomiting, pain, shortness of breath, insomnia, appetite loss, constipation and diarrhea, as well as physical, emotional, role, cognitive and social functioningat each visit. A baseline questionnaire also was completed prior to therapy.

Computer tomography and magnetic resonance imaging were utilized to categorize tumor response into three groupsa remission group, a stable disease group and a progressive disease group. Among all groups, significant improvement in emotional and social functioning, insomnia, appetite loss and diarrhea was noted. The most important improvements, such as diarrhea, pain, nausea and vomiting, were observed in patients who had tumor regression after therapy with 177Lu-octreotate, which suggests that the improvement was a direct result of the treatment.

"It seems highly desirable that in future studies on the efficacy of antitumor agentswhether with radiopharmaceuticals or other drugsquality of life evaluation forms be part of the evaluation of overall efficacy," noted Khan.


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Contact: Susan Martonik
smartonik@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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