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Benefit of glinides is not proven
Date:6/18/2009

ves, no relevant trials were identified that compared other drugs with glinides. In particular, there is a lack of comparator trials with newer glucose-lowering agents such as, for example, exenatides or gliptins. No trials were found even for well-established antidiabetics such as insulin or glitazones. It was only possible to compare glinides with metformin and sulfonylureas.

Neither benefit nor harm could be determined in the case of cardiovascular events

Treatment with oral antidiabetics is currently being discussed among experts, particularly with reference to the possible occurrence of cardiovascular events, such as heart attacks. The authors of the report therefore also analysed the existing trials on glinides with reference to the occurrence of cardiovascular events. However, none of the trials were designed to investigate a benefit or harm from glinides for this outcome. The only data on cardiovascular events appeared in analyses on adverse events. The low number of cases, however, do not permit any clear conclusion to be drawn concerning a benefit or harm from glinides with reference to cardiovascular events. Thus, for this aspect too, which is relevant in the selection of an antidiabetic, there is a lack of data. In this respect as well, IQWiG and its external experts see an urgent need for further research.


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Contact: Dr. Anna-Sabine Ernst
info@iqwig.de
49-022-135-685
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

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