Navigation Links
Benefit of glinides is not proven
Date:6/18/2009

The benefit of glinides in the treatment of type 2 diabetes is not scientifically proven. Nor do they perform better than other antidiabetics available in tablet form, such as metformin and sulfonylureas. As a result, there is also no proof of additional benefit. Although repaglinide has been approved for 10 years and nateglinide for 8 years in Germany, there have been no relevant trials to date of longer duration than 14 months. This is the conclusion of a report by the German Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, which was published in June 2009 and for which an English-language summary is now available.

Therapy option for patients with diabetes mellitus type 2

Usually, treatment for diabetes mellitus type 2, formerly known as adult-onset diabetes, starts with non-drug therapies, such as dietary changes, weight loss and physical exercise. If this does not reduce glucose levels sufficiently, then drugs can be used as well.

In addition to insulin, these include the oral antidiabetics (OAD). Besides glinides, this group also contains sulfonylureas, metformin and glitazones, for example. The individual substances, however, differ in their mechanism of action. Glinides stimulate the production of insulin in the pancreas. A particular feature of glinides is their rapid effect: if taken before meals, glinides lower glucose levels comparatively rapidly after eating.

At present, two substances from the drug class of glinides are approved in Germany and are thus the subject of this IQWiG investigation: repaglinide (NovoNorm from NovoNordisk) and nateglinide (Starlix from Novartis). There is, however, a slight difference in the approval of the two substances: while repaglinide is approved both as a monotherapy and as a therapy in combination with metformin, here in Germany nateglinide may only be prescribed in combination with metformin.

No long-term trials available

The
'/>"/>

Contact: Dr. Anna-Sabine Ernst
info@iqwig.de
49-022-135-685
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Ambulatory oxygen rarely a benefit in COPD patients without resting hypoxemia
3. Discovery of sugar sensor in intestine could benefit diabetes
4. Study shines more light on benefit of vitamin D in fighting cancer
5. Vitamin Es lack of heart benefit linked to dosage
6. Practice-based intervention has sustained benefits for children and families
7. Manic phase of bipolar disorder benefits from breast cancer medication
8. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
9. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
10. The Butterfly Ball to Benefit Lung Association
11. Smaller breast reduction surgeries provide health benefits and should be reimbursed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 2014 Daily Gossip writes in its Xtreme ... as the fastest fat loss program ever developed. It promises ... month. , There is no wonder after all that this ... time. The new nutrition and workout fat loss program was ... , According to the author of this fat loss ...
(Date:10/31/2014)... At the start of 2014, numerous news ... monoxide poisoning in their homes. Now, as 2015 (and ... Missouri-based heating and cooling company is taking a more ... the home heating season with the assurance that their ... Nov. 1, 2014, E and Q Heating and Cooling ...
(Date:10/31/2014)... 31, 2014 Energy Textiles has recently ... new gear is now available online, and Energy Textile ... of Celliant infrared-active athletic gear over compression gear. , ... contract has been signed for Under Armour to provide ... next eight years. In light of this decision, Energy ...
(Date:10/31/2014)... Oct. 31, 2014 (HealthDay News) -- Obesity increases the ... black and Hispanic women, two new U.S. studies show. ... found being overweight or obese increased the risk for ... women. "We,ve known this for a long time ... also in Hispanic women," study author Esther John, a ...
(Date:10/31/2014)... four older Americans say that either they or a ... according to the latest issue of The Gerontological Society ... ( PP&AR ), which goes on to show that ... to honor patients, end-of-life health care wishes. , This ... and Options ," features 12 articles that present new ...
Breaking Medicine News(10 mins):Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Study Confirms Obesity-Breast Cancer Link for Blacks, Hispanics 2Health News:Advance directives can benefit patients, families, and health care system 2
... patient,s DNA may lead to routine gene scans, experts ... In a genetics first, researchers report that they have ... acute myelogenous leukemia. , There were some surprises -- ... genetic alterations, were associated with the blood cell cancer. ...
... The Medical College of Georgia announced today that it ... the Bill & Melinda Gates Foundation. The grant ... by Dr. Pandelakis A. Koni titled "Antibody-Dependent Cellular Cytotoxicity ... is one of 104 grants recently announced by the ...
... 5 Dialysis Corporation,of America (Nasdaq: DCAI ... secured,revolving credit facility with KeyBank National Association to ... agreement provides for both,base rate and LIBOR loans ... the bank,s base rate or the London InterBank ...
... WEXFORD, Pa., Nov. 5 Millennium Pharmacy Systems, ... Health Care Center in,Bridgeport, West Virginia, its first ... more than 100 facilities in four states: Pennsylvania,Maryland, ... Administrator, states, "The Millennium,system was more advanced than ...
... founded a state-of-the-art eye care facility in Tanzania ... BERKELEY, Calif., Nov. 5 Today, Seva,Foundation ... in,the fight against preventable blindness around the world ... Yesterday, the Kilimanjaro Center for Community Ophthalmology (KCCO),which ...
... The American Heart,Association and its Pharmaceutical Roundtable ... Research Centers initiative. The project,will provide a network ... results, or outcomes, of healthcare for people with ... The initiative is supported in part by a ...
Cached Medicine News:Health News:First-Ever Mapping of Cancer Patient's Genome 2Health News:First-Ever Mapping of Cancer Patient's Genome 3Health News:MCG receives $100,000 Grand Challenges Explorations grant for innovative global health research 2Health News:Dialysis Corporation of America Announces $25 Million Credit Facility 2Health News:Millennium Pharmacy Systems Expands into West Virginia 2Health News:Seva Foundation Recognizes Paul Courtright and Susan Lewallen for Their Commitment to Blindness Prevention 2Health News:Seva Foundation Recognizes Paul Courtright and Susan Lewallen for Their Commitment to Blindness Prevention 3Health News:Four Medical Centers Awarded Funds to Improve Outcomes Research for Heart Disease and Stroke 2
(Date:10/31/2014)... , Oct. 31, 2014  Semler Scientific, ... emerging medical risk assessment company that develops patented ... and evaluating chronic diseases, today reported financial results ... September 30, 2014. "In the ... Doug Murphy-Chutorian , M.D., chief executive officer ...
(Date:10/31/2014)... Therapeutics, Inc. (NYSE MKT: MSTX), a clinical-stage biopharmaceutical company, ... 30, 2014. Brian M. Culley, the ... productive for Mast. Consistent with prior guidance, our 388-patient pivotal ... is on track to complete enrollment by the end ... in the U.S. and more than ten study sites ...
(Date:10/31/2014)... Mich. , Oct. 31, 2014  Lycera ... modulators to treat autoimmune disease and cancer, today ... novel synthetic RORgamma agonist product candidates will be ... for Immunotherapy of Cancer (SITC) being held November ... Convention Center, National Harbor, MD.  The poster, entitled ...
Breaking Medicine Technology:Semler Reports Third Quarter 2014 Financial Results 2Semler Reports Third Quarter 2014 Financial Results 3Mast Therapeutics Reports Third Quarter 2014 Financial Results 2Mast Therapeutics Reports Third Quarter 2014 Financial Results 3Mast Therapeutics Reports Third Quarter 2014 Financial Results 4Mast Therapeutics Reports Third Quarter 2014 Financial Results 5Mast Therapeutics Reports Third Quarter 2014 Financial Results 6Mast Therapeutics Reports Third Quarter 2014 Financial Results 7Mast Therapeutics Reports Third Quarter 2014 Financial Results 8Lycera Announces Presentation of Data on Anti-Tumor Activity of Novel Synthetic RORgamma Agonists at Society for Immunotherapy of Cancer Meeting 2
... 2011 Emmy®-nominated actress Christina Hendricks, in partnership with Allergan, ... (bimatoprost ophthalmic solution) 0.03% is calling on women to help ... Make-A-Wish Foundation by November 30 through the LATISSE® Wishes ... tradition of blowing on an eyelash to make wishes come ...
... Now available for endoscopic dilation of the ... Corporation,s (NYSE: BSX ) CRE™ Wireguided Balloon ... the Sphincter of Oddi following sphincterotomy.  The new indication, ... the alimentary (digestive) tract, lets physicians perform Dilation Assisted ...
Cached Medicine Technology:Actress Christina Hendricks Urges Women to Join Her in the Final Weeks of the LATISSE® Wishes Challenge to Increase Money Raised for the Make-A-Wish Foundation® from $390,000 to Campaign Goal of $500,000 2Actress Christina Hendricks Urges Women to Join Her in the Final Weeks of the LATISSE® Wishes Challenge to Increase Money Raised for the Make-A-Wish Foundation® from $390,000 to Campaign Goal of $500,000 3Actress Christina Hendricks Urges Women to Join Her in the Final Weeks of the LATISSE® Wishes Challenge to Increase Money Raised for the Make-A-Wish Foundation® from $390,000 to Campaign Goal of $500,000 4Actress Christina Hendricks Urges Women to Join Her in the Final Weeks of the LATISSE® Wishes Challenge to Increase Money Raised for the Make-A-Wish Foundation® from $390,000 to Campaign Goal of $500,000 5Actress Christina Hendricks Urges Women to Join Her in the Final Weeks of the LATISSE® Wishes Challenge to Increase Money Raised for the Make-A-Wish Foundation® from $390,000 to Campaign Goal of $500,000 6Boston Scientific CRE™ Wireguided Balloon Dilator CE Marked for Expanded Indication 2Boston Scientific CRE™ Wireguided Balloon Dilator CE Marked for Expanded Indication 3Boston Scientific CRE™ Wireguided Balloon Dilator CE Marked for Expanded Indication 4
Toxoplasma IgM II ELISA....
HSV 1 & HSV 2 DFA Test....
Herpes Simplex Virus 2 IgG ELISA....
Herpes Simplex Virus 1 IgG ELISA....
Medicine Products: