Navigation Links
Benefit of glinides is not proven
Date:6/18/2009

The benefit of glinides in the treatment of type 2 diabetes is not scientifically proven. Nor do they perform better than other antidiabetics available in tablet form, such as metformin and sulfonylureas. As a result, there is also no proof of additional benefit. Although repaglinide has been approved for 10 years and nateglinide for 8 years in Germany, there have been no relevant trials to date of longer duration than 14 months. This is the conclusion of a report by the German Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, which was published in June 2009 and for which an English-language summary is now available.

Therapy option for patients with diabetes mellitus type 2

Usually, treatment for diabetes mellitus type 2, formerly known as adult-onset diabetes, starts with non-drug therapies, such as dietary changes, weight loss and physical exercise. If this does not reduce glucose levels sufficiently, then drugs can be used as well.

In addition to insulin, these include the oral antidiabetics (OAD). Besides glinides, this group also contains sulfonylureas, metformin and glitazones, for example. The individual substances, however, differ in their mechanism of action. Glinides stimulate the production of insulin in the pancreas. A particular feature of glinides is their rapid effect: if taken before meals, glinides lower glucose levels comparatively rapidly after eating.

At present, two substances from the drug class of glinides are approved in Germany and are thus the subject of this IQWiG investigation: repaglinide (NovoNorm from NovoNordisk) and nateglinide (Starlix from Novartis). There is, however, a slight difference in the approval of the two substances: while repaglinide is approved both as a monotherapy and as a therapy in combination with metformin, here in Germany nateglinide may only be prescribed in combination with metformin.

No long-term trials available

The
'/>"/>

Contact: Dr. Anna-Sabine Ernst
info@iqwig.de
49-022-135-685
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Ambulatory oxygen rarely a benefit in COPD patients without resting hypoxemia
3. Discovery of sugar sensor in intestine could benefit diabetes
4. Study shines more light on benefit of vitamin D in fighting cancer
5. Vitamin Es lack of heart benefit linked to dosage
6. Practice-based intervention has sustained benefits for children and families
7. Manic phase of bipolar disorder benefits from breast cancer medication
8. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
9. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
10. The Butterfly Ball to Benefit Lung Association
11. Smaller breast reduction surgeries provide health benefits and should be reimbursed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... ... 05, 2015 , ... Stelari introduces their new collection, The Earth’s Song, inspired ... line, The Earth’s Song. Combining fashion and activewear, Stelari’s new collection let’s you take ... Australian Outback, this collection is sure to make the spirit seeker swoon with prints ...
(Date:8/5/2015)... (PRWEB) , ... August 05, 2015 , ... ... critical research funding, as well as awareness, education and support in order to ... Brain Aneurysm Foundation proudly announces this year it has awarded the most ...
(Date:8/4/2015)... ... ... MONTICELLO, Fla. – After completing 2,400 hours in the Clinical Pastoral Education Programs ... clinician allowed Dr. Barbara Thomas-Reddick to gain the skills and the know-how ... friends and staff, and she was able to witness after leaving the patients’ bedside, ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... Statement by ... applauds the introduction of the Mental Health Reform Act of 2015 by ... comprehensive mental health reform a reality in America. , “This legislation and ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... uses Cloud innovation to consolidate oncology patient assistance programs. Through a secure web ... of access. assistPoint is an enterprise level, cloud-based application and workflow solution. This ...
Breaking Medicine News(10 mins):Health News:Stelari: Bohemian Chic Activewear Line 2Health News:Stelari: Bohemian Chic Activewear Line 3Health News:Brain Aneurysm Foundation Awards Largest Amount of Research Funding at 9th Annual Brain Aneurysm Foundation Research Grant Awards Symposium Sept 10th in Houston, Texas 2Health News:Brain Aneurysm Foundation Awards Largest Amount of Research Funding at 9th Annual Brain Aneurysm Foundation Research Grant Awards Symposium Sept 10th in Houston, Texas 3Health News:Brain Aneurysm Foundation Awards Largest Amount of Research Funding at 9th Annual Brain Aneurysm Foundation Research Grant Awards Symposium Sept 10th in Houston, Texas 4Health News:New book shows how ‘The Presence of a Chaplain’ affects lives 2Health News:New book shows how ‘The Presence of a Chaplain’ affects lives 3Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 3Health News:assistPoint.com Web Site Launched 2
... , ... a company dedicated to disseminating information on dentistry,s role in the recognition and management of ... web site for the second month in a row. , ... New York, NY (PRWEB) July 31, 2009 -- Snoring Isn,t ...
... , WHITE PLAINS, N.Y., July 30 The ... University of Chicago, a pioneer in demonstrating that cancer is a ... President Barack Obama will award the Medals of Freedom, the nation,s ... Aug. 12, 2009. , , Dr. Rowley is ...
... , , , ... and Consumer Product Safety, The Pew Charitable Trusts: , , ... and strengthen the nation,s food safety system. This historic action takes a ... of their food. , , "Foodborne disease kills one ...
... Calls on Senate to Follow Suit , , ... commended the members of the United States House of Representatives for passing ... passed the House by a vote of 283-142. , , ... an important milestone," said Ms. Bailey. "This legislation will strengthen our ...
... , BOISE, Idaho, July 30 ... named John Stellmon, president of Regence BlueShield of Idaho, to ... In his new expanded role, effective August 1, ... health management programs. He will also oversee Pharmacy Services, Network ...
... implemented, expert says , THURSDAY, July 30 (HealthDay ... lead to reduced use of palliative care, Belgian researchers ... Group in Brussels also found that dying patients who ... life were more likely to choose euthanasia or physician-assisted ...
Cached Medicine News:Health News:SnoringIsntSexy.com Tops 21,000 Site Visits for Second Month in a Row 2Health News:Janet Rowley, MD, A Researcher Funded by The Leukemia & Lymphoma Society, Receives Presidential Medal of Freedom 2Health News:GMA Applauds U.S. House for Passage of Landmark Food Safety Bill 2Health News:Regence BlueShield of Idaho Announces Executive Changes 2Health News:Regence BlueShield of Idaho Announces Executive Changes 3Health News:Euthanasia, Palliative Care Work in Unison in Belgium 2
(Date:8/4/2015)... Aug. 4, 2015  Dr. Keesha Ewers ... potential FDA approval of flibanserin, or what is ... the treatment of decreased female sexual desire back ... root causes and addressing libido as a singular ... Photo ...
(Date:8/4/2015)... -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) today reported ... the three and six months ended June 30, 2015, ... and $43.4 million for the same periods in 2014. ... the more than $90 million of revenue Isis earned ... from Bayer to license  ISIS-FXI Rx .  Isis increased ...
(Date:8/4/2015)... , Aug. 4, 2015  Intec Pharma Ltd. (the ... company focused on developing drugs based on its proprietary ... its initial public offering in the United ... at a price to the public of $6.00 per ... the ordinary shares are being offered by the Company.  ...
Breaking Medicine Technology:Potential FDA Approval of "Pink Viagra" Sends Wrong Message 2Potential FDA Approval of "Pink Viagra" Sends Wrong Message 3Potential FDA Approval of "Pink Viagra" Sends Wrong Message 4Potential FDA Approval of "Pink Viagra" Sends Wrong Message 5Isis Reports Financial Results And Highlights For Second Quarter 2015 2Isis Reports Financial Results And Highlights For Second Quarter 2015 3Isis Reports Financial Results And Highlights For Second Quarter 2015 4Isis Reports Financial Results And Highlights For Second Quarter 2015 5Isis Reports Financial Results And Highlights For Second Quarter 2015 6Isis Reports Financial Results And Highlights For Second Quarter 2015 7Isis Reports Financial Results And Highlights For Second Quarter 2015 8Isis Reports Financial Results And Highlights For Second Quarter 2015 9Isis Reports Financial Results And Highlights For Second Quarter 2015 10Isis Reports Financial Results And Highlights For Second Quarter 2015 11Isis Reports Financial Results And Highlights For Second Quarter 2015 12Isis Reports Financial Results And Highlights For Second Quarter 2015 13Isis Reports Financial Results And Highlights For Second Quarter 2015 14Isis Reports Financial Results And Highlights For Second Quarter 2015 15Isis Reports Financial Results And Highlights For Second Quarter 2015 16Intec Pharma Ltd. Announces Pricing of U.S. Initial Public Offering 2Intec Pharma Ltd. Announces Pricing of U.S. Initial Public Offering 3
... authorization for prescription medications is a time-consuming process for ... faxes and hard-copy request forms. While some on-line solutions ... solution and one that is integrated with available e-prescribing ... in the marketplace, CVS Caremark (NYSE: CVS ...
... 2011 Relying on a proven partnership, ... Software Systems ChartSmart® Electronic Medical Records as ... toward improved clinical care which will also ... guidelines in order to qualify for federal ...
Cached Medicine Technology:CVS Caremark to Pilot Electronic Prior Authorization to Help Speed Patient Access to Prescription Medication 2CVS Caremark to Pilot Electronic Prior Authorization to Help Speed Patient Access to Prescription Medication 3Sharkey Issaquena Community Hospital Implements ChartSmart emr® 2Sharkey Issaquena Community Hospital Implements ChartSmart emr® 3
... loupes are ideal for general dental ... and a large field of view ... aligned, lightweight and comfortable to wear ... and superior depth of focus means ...
23 gauge thin wall irrigation. 25 gauge thin wall aspiration. Angled 30 degree shaft 8 mm from tip to bend. Irrigation tip set 0.5 mm behind aspiration tip. Dual hub construction. Polished finish. Ov...
23 gauge cannula (E4969 L) with 0.33 mm aspiration port, curved shaft and polished finish. Includes Teflon irrigating sleeve (E4969 SL). Uses 60 cm (23.6 inches) of silicone tubing (N5941 5). Overall...
... come with five legs for extra stability. ... (total vertical travel 6"). 2" ball bearing ... fire retardant upholstery, available in black vinyl ... order. Top of the range pneumatic stool ...
Medicine Products: