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Benefit of exenatide has not yet been proven
Date:10/17/2007

ocedure is less time-consuming. The rapid report primarily serves to allow the Federal Joint Committee and other organisations involved to form an opinion. This report is usually not suitable to serve as a basis for policy-making decisions, as a submission of comments on the report prior to publication is not intended.

Background: exenatide

Exenatide is an incretin mimetic, i.e. it mimics the effects of an incretin produced in the body, GLP-1. Incretins are hormones that are produced in the gastrointestinal tract. In the pancreas, they stimulate insulin secretion and inhibit glucagon secretion, depending on the blood glucose level. In addition, they affect gastric as well as brain functions: they delay the emptying of the stomach and increase the feeling of satiety. In the body, the incretin GLP-1 is degraded by an enzyme, which is why the hormone itself is not a suitable drug. In the early 1990s, researchers discovered a hormone in the saliva of the North-American Gila monster; this hormone has a very similar structure to GLP-1, but is not degraded as rapidly in the human body. They further developed this original substance to the drug exenatide. Exenatide was approved in April 2005 in the USA as the first drug of this new drug class, and approved in Europe in November 2006. The manufacturer Eli Lilly introduced exenatide onto the German market in May 2007.


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Contact: Anna-Sabine Ernst
anna-sabine.ernst@iqwig.de
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

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