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Benefit of exenatide has not yet been proven
Date:10/17/2007

between exenatide and insulin glargine. According to this, patients treated either with exenatide or with insulin glargine gained flexibility regarding meals and daily activities, and were generally more satisfied with treatment than before. Both groups achieved similarly good results. However, results may have been biased in favour of exenatide, as data from patients who discontinued the study due to adverse events were not included in the evaluation. Regarding the therapy goals "quality of life and "treatment satisfaction, IQWiG did not identify an advantage for either treatment option.

Long-term benefit or harm remains unclear

In its conclusion, IQWiG notes that although the blood-glucose lowering effect of exenatide has been demonstrated, a benefit has not. This is due to the fact that no relevant data from studies are available that allow statements on a positive or negative effect on late complications of diabetes, mortality, frequency of inpatient treatment, or frequency of comas caused by acute metabolic imbalance. To what extent the weight reduction helps reduce the rate of late complications of diabetes has not yet been investigated. Moreover, it is unclear whether and, if so, what adverse effects occur with long-term exenatide therapy. On the basis of the data available, a long-term (additional) benefit or harm can therefore neither be proven nor excluded.

Background: rapid report

The commission to evaluate the therapeutic benefits and harms of exenatide was to be performed in an accelerated procedure by means of a rapid report. During the preparation of a rapid report, in contrast to the usual procedure, the report plan and preliminary report are not published. Although the preliminary version of the rapid report undergoes an external review, no hearing takes place in which all interested persons can submit comments on this version. In addition, as no deadlines need to be kept for the publication of the report, the whole pr
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Contact: Anna-Sabine Ernst
anna-sabine.ernst@iqwig.de
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

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