Navigation Links
Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations
Date:2/11/2008

prospectively for three years via questionnaire and medical record review.

Investigators found that RRSO was associated with a 72 percent breast cancer risk reduction in women with BRCA2 mutations nearly twice the reduction in breast cancer risk compared to women with BRCA1 mutations. The surgery also reduced the risk of gynecologic cancer by 85 percent in women with a BRCA1 mutation. While protection against gynecologic cancer was suggested in women with a BRCA2 mutation, researchers were not able to estimate the level of reduced risk due to the low incidence of gynecologic cancers among women with these mutations.

Further analyses demonstrated that RRSO appeared to reduce the risk of estrogen receptor (ER)-positive breast cancer by 78 percent in women with a mutation in either BRCA1 or BRCA2, but had no effect on the development of ER-negative breast cancers. Because BRCA1 carriers are more likely to be diagnosed with ER-negative breast cancers, the authors note that carriers of these mutations need to consider additional breast-cancer-risk-reduction strategies, such as intensive screening with breast MRI or prophylactic mastectomy.

While our results suggest that removal of the ovaries in women with BRCA1 or BRCA2 mutations is highly protective against ER-positive breast cancers, further research is urgently needed to develop effective non-surgical prevention strategies for the ER-negative cancers that are frequently associated with these mutations, said Dr. Kauff.


'/>"/>

Contact: Esther Napolitano
napolite@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Ambulatory oxygen rarely a benefit in COPD patients without resting hypoxemia
3. Discovery of sugar sensor in intestine could benefit diabetes
4. Study shines more light on benefit of vitamin D in fighting cancer
5. Vitamin Es lack of heart benefit linked to dosage
6. Practice-based intervention has sustained benefits for children and families
7. Manic phase of bipolar disorder benefits from breast cancer medication
8. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
9. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
10. The Butterfly Ball to Benefit Lung Association
11. Smaller breast reduction surgeries provide health benefits and should be reimbursed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... (PRWEB) , ... July 03, ... ... announced the sessions and speaker lineup for its 2015 Annual Conference ... place August 6-8, 2015 at the Renaissance Orlando at SeaWorld in Orlando, ...
(Date:7/3/2015)... ... 03, 2015 , ... The Erie County Bar Association Institute ... The Association welcomed speaker C. Daniel McGillicuddy Esq. of William Mattar Law Offices. ... investigating these types of cases. , Each year, New York State residents are ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ” was featured ... coolest technology products available to consumers. Amanda Forstrom, a technology expert and special reporter ... great for documenting memories. , Almost every smartphone has an incredibly powerful camera built ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce ... sweetFrog store located in the Lone Star State. The premium frozen yogurt chain was listed ... store, which opened June 19 in the Village at Bachman Lake, is located at:, 3701 ...
(Date:7/2/2015)... ... , ... Many Fourth of July celebrations will include fireworks this summer, so ... sharing some tips to promote the proper use of fireworks. , According to the ... daily with fireworks-related injuries in the month surrounding the Fourth of July. Amica is ...
Breaking Medicine News(10 mins):Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 3Health News:Attorney from William Mattar Leads Discussion on Bicycle Accidents 2Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:6 Fireworks Safety Tips from Amica Insurance 2
... study suggests, , WEDNESDAY, Jan. 20 (HealthDay News) -- ... drills, say German researchers. , They found that firing ... tooth structure beneath the enamel coating -- reduced the ... results suggest that plasma jets could be used to ...
... ... , ... MD (Vocus) January 20, 2010 -- Healthy Directions, LLC, is proud to announce ... top quality natural solutions to today’s most pressing health concerns. The new Web ...
... CHICAGO , Jan. 20 According to ... American Journal of Health Promotion , a peer-reviewed journal devoted ... activities within an incentive-based health insurance wellness program had significantly ... data over one year of 948,974 adult members of ...
... benefit patients, survey reports , WEDNESDAY, Jan. 20 (HealthDay ... medical students think that knowledge of complementary and alternative ... , Complementary and alternative medicine, or CAM, includes ... , "Even with the high prevalence of CAM use ...
... ... decisions are substantiated by accurate data analysis and reporting, four colleges within the ... , ... NH (PRWEB) January 20, 2010 -- In today’s technology-driven environment, where sound business ...
... ... On January 2 of this year, Freedom From Covert Harassment and Surveillance ... This event coincides with January as National Stalking Awareness Month. Organized ... may not even know why the stalking is occurring, has emerged with ...
Cached Medicine News:Health News:Healthy Directions, LLC, Announces Launch of Online Resource for Premium Quality Natural Health Solutions 2Health News:Research Indicates Participants in Incentive-Based Health Promotion Programs Have Lower Healthcare Costs 2Health News:Research Indicates Participants in Incentive-Based Health Promotion Programs Have Lower Healthcare Costs 3Health News:Research Indicates Participants in Incentive-Based Health Promotion Programs Have Lower Healthcare Costs 4Health News:New Hampshire Community Colleges Choose Rapid Insight for Data Reporting Needs 2Health News:FFCHS Launches Online Petition Against Organized Stalking and Electronic Torture 2Health News:FFCHS Launches Online Petition Against Organized Stalking and Electronic Torture 3Health News:FFCHS Launches Online Petition Against Organized Stalking and Electronic Torture 4
(Date:7/2/2015)...   Decision Resources Group finds that ... frequent dosing as the highest unmet need in ... on both patients and providers associated with monthly ... which are the current standard of care. The ... in development for dosing every two to three ...
(Date:7/2/2015)... , July 2, 2015  Konica Minolta, Inc. (Konica ... that it has acquired Sawae Technologica Ltda., an X-ray ... Brazil , through its Brazilian healthcare sales company, ... Local Brazil market ... increasing population exceeding 200 million, significant healthcare technical advancements ...
(Date:7/2/2015)... Ill. , July 2, 2015  AbbVie (NYSE: ... results on Friday, July 24, 2015, before the market ... of the earnings conference call at 8 a.m. Central ... AbbVie,s Investor Relations website at www.abbvieinvestor.com . An ... 11 a.m. Central time. About AbbVie ...
Breaking Medicine Technology:Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 3Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 2Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 3
... treated with Satraplatin Demonstrated Statistically,Significant Improvement in ... March 22, 2007 /PRNewswire-FirstCall/ -- Pharmion,Corporation and ... from,the double-blind, randomized satraplatin Phase 3 registrational,trial, ... Cancer) which were presented today at the ...
... Scientists,at WEHI have made a discovery with potentially ... undergoing,cancer chemotherapy. , The research team led by ... platelet life span is controlled by two key,molecules. ... new,drug to prolong the life span of platelets ...
Cached Medicine Technology:Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 2Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 3Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 4Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 5Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 6Additional Data From Satraplatin SPARC Phase 3 Trial Presented at,European Association of Urology Congress 7Major Discovery Raises Prospect of Better Patient Care By Improving,Platelet Life Span 2Major Discovery Raises Prospect of Better Patient Care By Improving,Platelet Life Span 3
... VACOPED is a revolutionary cast replacement system ... lower leg and foot. , ,A ... anatomy and in conjunction with a rigid ... general time of fracture or rupture healing ...
... therapeutic benefits of controlled compression and cold, ... pain. The anatomically designed cuff provides complete ... be ordered as a single cuff, or ... and insulation disk). The Cooler is available ...
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
Qualcare™ Thumb Spica...
Medicine Products: