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Benefit of PET or PET/CT in recurrent bowel cancer is not proven
Date:12/10/2012

nostic power of PET or PET/CT had been compared with other diagnostic techniques. This referred to the question as to how often a PET investigation provides a correct result. On the one hand, true malignant tumours should be overlooked as rarely as possible, while on the other, false suspicions should not be aroused.

The results of a total of 5 evidence syntheses and 13 individual studies regarding this question could be evaluated. The conclusion on recurrence detection was as follows: PET and PET/CT appear capable of detecting or excluding recurrences more reliably than a conventional diagnostic intervention consisting solely or predominantly of CT. This applies particularly to local recurrences and distant metastases. It is not possible to state with certainty whether PET and PET/CT differ in terms of their diagnostic accuracy.

Further study results needed

Important questions in relation to PET technology remain unanswered. For example, it has not yet been examined whether the higher accuracy of PET or PET/CT has a positive effect on mortality, the burden of disease or quality of life.

As long as this deficiency remains, a patient-relevant benefit of PET or of PET/CT as a supplementation to a suspicion-driven diagnostic investigation with conventional methods is not proven. For instance, it is particularly doubtful whether a recurrence detected by using PET or PET/CT can actually be better treated and thereby produce a perceptible advantage for patients. Experts are therefore eagerly awaiting the results of a Canadian study with more than 400 patients, which is to be published shortly.

Missing information can lead to false conclusions

Stefan Lange, the Deputy Director of IQWiG, commented on the new information gained by IQWiG during the assessment procedure of the study on laparotomies: "The fact that the only benefit study on PET turned out to be unsuitable is extremely regrettable. The rupture
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Contact: Anna-Sabine Ernst
presse@iqwig.de
49-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

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