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Benefit of PET or PET/CT in recurrent bowel cancer is not proven
Date:12/10/2012

had examined the consequences of a diagnostic intervention using PET or PET/CT on health aspects of direct relevance to patients. For example, the results of the diagnostic investigation - and appropriately tailored treatment - could contribute to better chances of survival for patients, spare them unnecessary operations or further diagnostic interventions, or improve their quality of life.

As requested by the contracting agency, the Federal Joint Committee (G-BA), this report was to focus on those patients in whom a recurrence had already been detected or in whom there was at least a justified suspicion thereof.

The only benefit study proved to be unsuitable

In its final assessment IQWiG was unable to include any studies that had investigated benefits of relevance to patients. For the preliminary report, i.e. the preliminary results, IQWiG had evaluated one study. This addressed the question as to whether, in patients in whom potentially operable liver metastases were suspected, unnecessary laparotomies (surgical opening of the abdomen) could be avoided if a PET investigation took place following a diagnostic intervention using contrast-medium-enhanced CT.

As IQWiG has since discovered after requesting information from authors, this study was, however, unsuitable for deriving any conclusions regarding benefit. This was because - in contrast to the original plan - the decision to operate or not was not allowed to be made in dependence upon the PET results. The independent advisory committee had advised against this procedure on ethical grounds. But information on this important change in the conduct of the study was provided neither in the publication of the study results nor by entry in a clinical trials registry.

In certain cases, PET/CT can detect recurrences more reliably

For the preliminary report, IQWiG had already made an additional search for studies in which the diagnostic accuracy and prog
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Contact: Anna-Sabine Ernst
presse@iqwig.de
49-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

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