Navigation Links
'Beneficial inflammation' may promote healing in pulmonary fibrosis
Date:4/25/2014

Inflammation has long been considered an integral part of the biological process that leads to deadly scarring in idiopathic pulmonary fibrosis. New research at National Jewish Health, however, suggests that a little inflammation may also be crucial to the healing and repair processes in the lungs. Elizabeth Redente, PhD, assistant professor of cell biology at National Jewish Health, and her colleagues report in the April 2014 issue of the American Journal of Respiratory Cell and Molecular Biology that the pro-inflammatory cytokine TNF-α can speed recovery of injured lungs and accelerate the resolution of established fibrosis in a mouse model.

"The role of inflammation in the development of scarring has been hotly debated in recent years," said Dr. Redente. "Our findings show for the first time that TNF-α actually promotes inflammation during the resolution of established scarring. A little inflammation may actually be a good thing in the right place and time."

Idiopathic pulmonary fibrosis is a relentless, progressive scarring of the lungs for which there is no approved medical therapy. The disease has no known cause and patients generally die within three years of diagnosis. Approximately 40,000 Americans die of idiopathic pulmonary fibrosis every year.

Inflammation was long believed to be a precursor and cause of scarring in the lungs. However, anti-inflammatory treatments have shown no positive effect on the progress of the disease. In recent years, some researchers have thought that inflammation may be part of the healing process as well as the scarring of the lungs.

Dr. Redente and her colleagues gave mice TNF-α after their lungs had been injured and developed scar tissue. While these mice do normally heal from the lung injury, the researchers found that the TNF-α accelerated the recovery process. It reduced levels of collagen, the main component of scar tissue, and improved the flexibility of lung tissue wel
'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Is therapeutic hypothermia beneficial in all patients following cardiac arrest?
2. Blood pressure medications given right after stroke not beneficial, study finds
3. Study finds mammography beneficial for younger women
4. Multi-component therapy shown beneficial in treating PTSD in adolescent girls
5. Forbes Living to Broadcast a Beneficial Senior Fitness Segment
6. Weight loss not always beneficial for romantic relationships
7. Milaa Is Set to Introduce an Online Parenting Platform for Today’s Face-Pasted Parents with Activities That Are Beneficial for Their Children’s Development
8. New from Sublime Beauty®: Fresh Citrus Scrub with Beneficial AHAs to Refresh, Invigorate and Gently Exfoliate
9. Researchers Find That Setting Weight Loss Ranges Are More Beneficial than Specifics, Making Weight Loss Via Supplements Like Prescopodene More Likely
10. FDA Review Article Provides New Insights into Cancer Immunotherapy Product Development; Beneficial to all Involved in Cancer Treatment
11. Vitamin C may be beneficial against exercise-induced bronchoconstriction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... By Dennis Thompson ... -- A newborn,s risk of developing celiac disease isn,t reduced ... found in wheat called gluten to an infant,s diet help ... a pair of new studies in the Oct. 2 ... put to rest hopes that a child could avoid celiac ...
(Date:10/2/2014)... The University of Nottingham could lead to the development ... drug resulting from the research, published in the journal ... to sufferers of chronic pain conditions such as traumatic ... available. , The work, led by Dr Lucy Donaldson ... with David Bates, Professor of Oncology in the University,s ...
(Date:10/1/2014)... the Journal of the American Medical Association ... moderate or severe chronic knee pain, acupuncture did not ... Melbourne randomly assigned 282 patients (50 years or older) ... or pretend laser treatment. , Treatments were delivered ... laser and sham (inactive) laser acupuncture. , Researcher Professor ...
(Date:10/1/2014)... a policy focus on expanding access to care ... continues to have significant dental disease. In this ... American Dental Association , researchers from Tufts University ... Dental Medicine report on the first large-scale survey ... by caregivers to adults with developmental disabilities. The ...
(Date:10/1/2014)... Insuranceragents.info has released a new blog post explaining how ... family members. , Life insurance plans provide important financial ... should always carry a life insurance policy as their ... the family. , Clients can choose from several ... coverage or from a permanent policy. No medical exam ...
Breaking Medicine News(10 mins):Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 2Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 3Health News:Medical discovery first step on path to new painkillers 2Health News:Study finds acupuncture does not improve chronic knee pain 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3Health News:Life Insurance for Families - Clients Can Compare Affordable Rates Online! 2
... Doctor Confirms Fall Should Not Pose Setback and Expects the 89-Year-Old ... Evangelist ... Graham has,returned to his mountain home in Montreat, N.C. upon his ... stay.,He was admitted for observation after he tripped over one of ...
... 6 likely to develop some form of disease by ... 10 (HealthDay News) -- Liver transplant patients have a ... researchers in Finland. , In a new study ... , researchers investigated the cancer risk pattern in 540 ...
... RICHMOND, Va., Oct. 10 Do you think that ... town? Attend the October,17 open house at the Virginia ... how instructors there empower the blind and,visually impaired to ... center., The center, located at 401 Azalea Avenue, ...
... CITY, Utah, Oct. 10 NuView Life Sciences ... Life Sciences Inc.,(Trace), including operations of the linear ... Trace facility produces,Copper-64, Copper- 67, Indium-111, Iodine-123 and ... Crowe, NuView Chairman and,CEO, stated that "We are ...
... , , FRIDAY, Oct. 10 (HealthDay News) -- In a group ... with a higher death rate, according to a new study. ... Journal of General Internal Medicine , researchers from the ... 75.6 years) who had diabetes and were enrolled in a ...
... scientists have identified a protein that plays matchmaker between ... B cells, enabling them to interact in a way ... infection. Their finding may also explain why some ... from making this proteincalled SAPsuffer from lethal infections with ...
Cached Medicine News:Health News:Billy Graham Returns Home Following Hospital Observation 2Health News:Liver Transplant Patients at Higher Cancer Risk 2Health News:Virginia Rehabilitation Center for the Blind and Vision Impaired Celebrates Opening of New Student Dormitory 2Health News:Older Diabetics With Depression Face Higher Death Rate 2Health News:NIH scientists discover crucial control in long-lasting immunity 2Health News:NIH scientists discover crucial control in long-lasting immunity 3
(Date:10/1/2014)... DIEGO , Oct. 1, 2014 ... molecular diagnostics, announced today that Eli Diamond ... Kettering Cancer Center (MSK), presented clinical data from ... precision cancer monitoring platform for the determination of ... a liquid biopsy.  The results were presented to ...
(Date:10/1/2014)... Oct. 1, 2014   Royal Philips ... announced its eCareCoordinator and eCareCompanion telehealth applications have ... Drug Administration (FDA). A part of Philips Hospital ... eCareCoordinator and eCareCompanion are focused on patient care ... applications to be available through the cloud-based digital ...
(Date:10/1/2014)... Switzerland , October 1, 2014 ... Genomics and Next Generation Sequencing (NGS) data analysis, today ... run full cystic fibrosis analysis in a single NGS ... characterisation of all types of variants in a single ... Until now, it has not been possible to simultaneously ...
Breaking Medicine Technology:Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 4Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4Sophia Genetics Launches Full CFTR Analysis in Single Clinical Grade NGS Experiment 2
... heart organizations representing cardiologists and cardiothoracic surgeons released ... aortic valve replacement (TAVR) programs. The recommendations are ... aortic stenosis, a form of valvular heart disease, ... Since the Food and Drug ...
... Calif., March 1, 2012  Heritage Provider Network presented checks ... Heritage Health Prize competition at the Strata Conference in ... the 12 month mark. Once again, ... competition, winning the top spot.  Players include David Vogel, ...
Cached Medicine Technology:Leading Cardiovascular Organizations Release Credentialing Recommendations for Heart Valve Replacement Procedure 2Leading Cardiovascular Organizations Release Credentialing Recommendations for Heart Valve Replacement Procedure 3Leading Cardiovascular Organizations Release Credentialing Recommendations for Heart Valve Replacement Procedure 4Leading Cardiovascular Organizations Release Credentialing Recommendations for Heart Valve Replacement Procedure 5Heritage Provider Network Awards $80,000 to the Progress Prize Winners in the $3Million Heritage Health Prize Contest at the Strata Conference in Santa Clara, California 2Heritage Provider Network Awards $80,000 to the Progress Prize Winners in the $3Million Heritage Health Prize Contest at the Strata Conference in Santa Clara, California 3
Inquire...
Inquire...
Inquire...
Inquire...
Medicine Products: