Navigation Links
Benaroya Research Institute scientists identify drivers of rheumatoid arthritis
Date:6/11/2014

(June 11, 2014 Seattle, Wash.) Researchers at Benaroya Research Institute at Virginia Mason (BRI) used cutting-edge tetramer technology developed at BRI to find the T cells that drive rheumatoid arthritis (RA). "By using tetramer technology, we were able to examine whether T cells in people with rheumatoid arthritis were increased in number or were unique in other ways," says BRI Associate Director Jane Buckner, MD, who led the study with BRI Tetramer Core Laboratory Manager Eddie James, PhD. The findings were recently reported online in Arthritis & Rheumatology.

This tool now allows scientists to study how RA starts, how current therapies may impact the immune response directed to the joint and how to specifically target these cells therapeutically. "For the first time, we were able to demonstrate that T cells that recognize proteins in the joint were increased in the blood of people with RA and that these cells had a unique set of markers. Further we were able to demonstrate that the number of these cells changes over time in patients and with treatment." BRI is an international leader in developing tetramer technology which allows scientists to isolate cells that are difficult to pinpoint, often compared to finding a needle in a haystack.

"RA is a debilitating disease affecting people of all ages including children," says Dr. Buckner. "Many people are diagnosed in their early 20's, 30's and 40's, and it impacts them at a very productive time of their lives. We used to see people with RA in wheelchairs and needing joint replacements, but during the last 15 years we have seen incredible progress in new therapies. If people are appropriately diagnosed and treated, they can work full time and be healthy, active adults. But they can still suffer and need medications that have risks and side effects. The drugs can be costly and sometimes they don't work or eventually stop working. If untreated, the disease will permanently destroy joints and cause pain. We would like to find ways to treat people early and target only the cells that cause the disease and eventually, prevent this disease."

Rheumatoid arthritis is thought to be a T cell mediated disease and is caused when the body's immune system mistakenly begins to attack its own tissues, primarily the synovium, the membrane that lines the joints. As a result of this autoimmune response, fluid builds up in the joints, causing joint pain and systemic inflammation.

RA is a chronic disease in which most people experience intermittent periods of intense disease activity punctuated by periods of reduced symptoms or even remission. In the long term, RA can cause damage to cartilage, tendons, ligaments and bones which can lead to substantial loss of mobility.

An estimated 1.3 million people in the United States have RAalmost 1 percent of the nation's adult population. There are nearly three times as many women as men with the disease. In women, RA most commonly begins between the ages of 30 and 60. In addition, as many as 300,000 children are diagnosed with a distinct but related form of inflammatory arthritis called juvenile arthritis.

This work was funded by an Autoimmune Disease Prevention grant from the National Institutes of Health. A new grant of $1.3 million from the U.S. Department of Defense will extend the discovery to ask in-depth questions about whether these T cells reflect disease activity and if they change in patients who respond to therapy. Drs. Buckner and James will lead the study with Bernard Ng, MD, Chief of Rheumatology, Veterans Affairs Puget Sound Healthcare System. Research will include biorepository studies of samples voluntarily provided by Veterans Affairs and BRI research participants who help to advance science.


'/>"/>

Contact: Kay Branz
kbranz@benaroyaresearch.org
206-342-6903
Immune Tolerance Network
Source:Eurekalert

Related medicine news :

1. Benaroya Research Institute announces $4.4 million grant for type 1 diabetes
2. Benaroya Research Institute receives 7-year award to lead Immune Tolerance Network
3. Benaroya Research Institute evaluates immunology approach to blocking breast cancer
4. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
5. NIH awards $20 million over 5 years to train next generation of global health researchers
6. Researchers develop a new cell and animal model of inflammatory breast cancer
7. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
8. Sexually abused boys at risk for more unsafe sex: UBC research
9. Researchers Find Gene Mutations That May Be a Key to Autism
10. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
11. Researchers find evidence of banned antibiotics in poultry products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... February 13, 2016 , ... When an Au Pair comes all the way ... they are in for and they are often worried things won’t go well. More often ... for. This year’s Au Pair of the Year winner’s all commented how their Au Pairs ...
(Date:2/12/2016)... ... February 12, 2016 , ... According to an ... beginning to account for a significant portion of hernia repairs throughout the United States. ... Beverly Hills Hernia Center notes that this trend has not only been expected, but ...
(Date:2/12/2016)... WA, and Washington, DC (PRWEB) , ... ... ... PATH and the Siemens Foundation today announced a new initiative—the Siemens Foundation-PATH ... for low-resource settings. The partnership will recruit top students from U.S. universities ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fixed Dose Combination ... 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination , Fixed dose combination ... garnering increased attention from all stakeholders in the development of new chemical entities. ...
(Date:2/12/2016)... CULVER CITY, California (PRWEB) , ... February 12, 2016 , ... ... to announce their participation in Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco ... and healthy way to stay hydrated before the big event. The invitation-only gifting suite, ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ARLZ ... Company will ring the Nasdaq Closing Bell at the ... at 4:00 p.m. ET on Tuesday, February ... Adrian Adams , will perform the honorary ... 4:00 p.m. ET.  A live webcast will be available ...
(Date:2/12/2016)... Ungarn, February 12, 2016 ... sich auf den ungedeckten medizinischen Bedarf bei ... Ergebnisse seines klinischen Forschungsprogramms bekannt. Das Programm, ... ergab Verbesserungen ihrer respiratorischen Funktionen und anderer ... , ein Medizintechnikunternehmen, das sich auf den ...
(Date:2/11/2016)... , Feb. 11, 2016 Stem cells ... are characterized by self-renewal and the capacity to differentiate ... relatively new discovery, as the first mouse embryonic stem ... was not until 1995 that the first culturing of ... stem cells were not produced until 2006 As a ...
Breaking Medicine Technology: