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Benaroya Research Institute receives 7-year award to lead Immune Tolerance Network
Date:1/23/2014

(Seattle, January 23, 2014) The National Institutes of Health (NIH) has awarded Benaroya Research Institute at Virginia Mason (BRI) a 7-year grant to lead the Immune Tolerance Network (ITN). The award, totaling $27 million annually, supports efforts to develop, coordinate and implement international clinical trials conducted by the ITN to evaluate novel therapies for transplantation, allergy and autoimmune diseases.

The Immune Tolerance Network (ITN) is a research consortium sponsored by the National Institute of Allergy and Infectious Diseases, part of NIH. ITN clinical and laboratory investigators conduct studies at more than 250 clinical sites in the U.S., Canada, England, Australia and Mexico. The ITN is led by Gerald Nepom, M.D., Ph.D., who is also director of BRI.

"This grant award enables the ITN to facilitate collaborative studies between academic, governmental and industry researchers across the landscape of immunologic disease," Dr. Nepom said. "Through its unique ability to assemble and guide these collaborations, the ITN is able to develop cutting-edge clinical trials and mechanistic studies in immune tolerance that would not otherwise be conducted. BRI is proud to have been selected by the NIH to lead this effort."

In addition to selecting BRI to lead the ITN, the award will support teams of clinical investigators and laboratory scientists in the U.S. and abroad who are evaluating specific immunological therapies in clinical trials carefully designed and integrated with mechanistic studies. Examples include studies to discontinue immunosuppression therapy in patients who receive kidney or liver transplants; to understand how patients can tolerate transplanted organs without drugs, to test novel immunobiologic agents in psoriasis, multiple sclerosis, lupus and type 1 diabetes; and to improve allergy desensitization therapies or prevent food allergy.

BRI is an international leader in researching causes of and tre
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Contact: Kay Branz
kbranz@benaroyaresearch.org
206-342-6903
Immune Tolerance Network
Source:Eurekalert

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