Navigation Links
Belly Fat May Make Some Breast Cancers More Likely
Date:12/15/2010

WEDNESDAY, Dec. 15 (HealthDay News) --Premenopausal women who carry excess fat around their abdomen or have a large waist relative to their hip size may face a higher risk for breast cancer that is estrogen receptor (ER)-negative, new research reveals.

The research team noted that such body fat distribution was linked more strongly to the risk for developing this particular type of cancer than it was to a risk for ER-positive breast cancer.

Body fat distribution of this kind was not associated with an increased risk for breast cancer generally, according to the study, published Dec. 15 in the Journal of the National Cancer Institute.

Estrogen receptor (ER)-negative breast cancer means that the cancer lacks receptors for the female hormone estrogen, so the hormone does not stimulate the cancer to grow.

The research team, led by Holly R. Harris of Brigham and Women's Hospital and Harvard Medical School in Boston, pointed out that prior research had suggested that body fat composition (as indicated by body mass index, or BMI) has a complex relationship with cancer risk. For example, having a higher BMI has previously been linked to a rise in the risk for postmenopausal breast cancer, but not premenopausal breast cancer.

On the other hand, the researchers said that premenopausal women who carry excess fat that wraps around organs in the abdominal region are more likely to develop the pre-diabetic condition known as hyperinsulinemia. Lab experiments have shown that insulin receptors can promote the growth of breast cancer cells.

In their latest investigation, Harris and her colleagues focused on data from more than 116,000 women who had been enrolled in the Nurses Health Study II since 1989, including waist and hip circumference, recorded in 1993.

The fact that ER-negative breast cancer was more strongly linked to abdominal fat and the waist-hip ratio than ER-positive breast cancer suggests, according to the researchers, that the means by which body fat distribution influences cancer risk sidesteps sex-hormone pathways.

The findings "may suggest that an insulin-related pathway" related to abdominal fat is involved in the development of premenopausal breast cancer, the authors wrote.

More information

The U.S. National Cancer Institute has more on breast cancer risk.

--Alan Mozes

SOURCE: Journal of the National Cancer Institute, Dec. 15, 2010, news release


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Compex , Leaders in Electronic Muscle Stimulators, Sponsors the Jelly Belly Cycling Team Presented by Kenda
2. Love handles repurposed for breast reconstruction in women without enough belly fat
3. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
4. Belly Fat in Middle Age Raises Dementia Risk
5. Belly-Baring Cheerleaders at Raised Risk of Eating Disorders
6. Just a Little Belly Fat Can Damage Blood Vessels
7. Study Hints at Stem Cells From Belly Fat as Treatment for Heart Attack
8. Belly fat puts women at risk for osteoporosis
9. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
10. Low forms of cyclin E reduce breast cancer drugs effectiveness
11. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Belly Fat May Make Some Breast Cancers More Likely
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
Breaking Medicine Technology: