Navigation Links
Belly Fat May Make Some Breast Cancers More Likely
Date:12/15/2010

WEDNESDAY, Dec. 15 (HealthDay News) --Premenopausal women who carry excess fat around their abdomen or have a large waist relative to their hip size may face a higher risk for breast cancer that is estrogen receptor (ER)-negative, new research reveals.

The research team noted that such body fat distribution was linked more strongly to the risk for developing this particular type of cancer than it was to a risk for ER-positive breast cancer.

Body fat distribution of this kind was not associated with an increased risk for breast cancer generally, according to the study, published Dec. 15 in the Journal of the National Cancer Institute.

Estrogen receptor (ER)-negative breast cancer means that the cancer lacks receptors for the female hormone estrogen, so the hormone does not stimulate the cancer to grow.

The research team, led by Holly R. Harris of Brigham and Women's Hospital and Harvard Medical School in Boston, pointed out that prior research had suggested that body fat composition (as indicated by body mass index, or BMI) has a complex relationship with cancer risk. For example, having a higher BMI has previously been linked to a rise in the risk for postmenopausal breast cancer, but not premenopausal breast cancer.

On the other hand, the researchers said that premenopausal women who carry excess fat that wraps around organs in the abdominal region are more likely to develop the pre-diabetic condition known as hyperinsulinemia. Lab experiments have shown that insulin receptors can promote the growth of breast cancer cells.

In their latest investigation, Harris and her colleagues focused on data from more than 116,000 women who had been enrolled in the Nurses Health Study II since 1989, including waist and hip circumference, recorded in 1993.

The fact that ER-negative breast cancer was more strongly linked to abdominal fat and the waist-hip ratio than ER-positive breast cancer suggests, according to the researchers, that the means by which body fat distribution influences cancer risk sidesteps sex-hormone pathways.

The findings "may suggest that an insulin-related pathway" related to abdominal fat is involved in the development of premenopausal breast cancer, the authors wrote.

More information

The U.S. National Cancer Institute has more on breast cancer risk.

--Alan Mozes

SOURCE: Journal of the National Cancer Institute, Dec. 15, 2010, news release


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Compex , Leaders in Electronic Muscle Stimulators, Sponsors the Jelly Belly Cycling Team Presented by Kenda
2. Love handles repurposed for breast reconstruction in women without enough belly fat
3. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
4. Belly Fat in Middle Age Raises Dementia Risk
5. Belly-Baring Cheerleaders at Raised Risk of Eating Disorders
6. Just a Little Belly Fat Can Damage Blood Vessels
7. Study Hints at Stem Cells From Belly Fat as Treatment for Heart Attack
8. Belly fat puts women at risk for osteoporosis
9. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
10. Low forms of cyclin E reduce breast cancer drugs effectiveness
11. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Belly Fat May Make Some Breast Cancers More Likely
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: