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Belly Fat May Be Tied to Kidney Damage
Date:4/12/2013

By Brenda Goodman
HealthDay Reporter

THURSDAY, April 11 (HealthDay News) -- So-called "apple-shaped" people who carry more fat around their bellies than their hips may be at higher risk of kidney disease, a new study suggests.

The study measured blood flow through the kidneys of 315 men and women in the Netherlands. Those who had higher waist-to-hip ratios, meaning they tended to store more fat around their bellies compared to their thighs, also had higher blood pressure in their kidneys, even if they were not overweight.

Over time, elevated blood pressure damages the small vessels in the kidneys and can decrease their ability to siphon waste from the blood.

The study found that each one-unit increase in waist-to-hip ratio was linked to a loss of blood flow through the kidney's tiniest filters, the glomeruli, of about 4 milliliters per minute.

To put that number in context, glomerular filtration rate drops about 1 milliliter per minute every year of normal aging, said Dr. Deidra Crews, a nephrologist and assistant professor at the Johns Hopkins University School of Medicine, in Baltimore.

"That is clinically significant, and argues strongly for patients to achieve and maintain a normal waist-to-hip ratio in order to lower their chances of kidney disease," said Crews, who was not involved in the study.

The finding was particularly striking to the researchers because "we found that association in healthy subjects who didn't have high blood pressure or diabetes," said study co-author Arjan Kwakernaak, a doctoral student at the University of Groningen Medical Center.

Body weight didn't seem to alter the association, but the bigger a person was, the more their risk increased.

"If you have a higher waist-to-hip ratio and you are overweight, you have even a higher risk of having elevated kidney blood pressure," Kwakernaak said.

The study was published online April 11 in the Journ
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