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Being overweight, obese during early adulthood associated with greater risk of pancreatic cancer
Date:6/23/2009

MI (per 5-unit increase) with cancer risk also was slightly stronger in ever smokers than in never smokers. It was estimated that 10.3 percent of never smokers and 21.3 percent of ever smokers had pancreatic cancer attributable to being overweight or obese at an early age prior to cancer diagnosis (i.e., from the ages of 14-59 years).

Individuals who were overweight or obese from the ages of 20 to 49 years had an earlier onset of pancreatic cancer by 2 to 6 years (median [midpoint] age of onset was 64 years for patients with normal weight, 61 years for overweight patients, and 59 years for obese patients). Compared with those with normal body weight and after adjusting for all clinical factors, individuals who were overweight or obese from the ages of 30 to 79 years or in the year prior to recruitment had reduced overall survival of pancreatic cancer regardless of disease stage and tumor resection status.

"While our observations require confirmation, they provide support for a role of excess body weight in the development and progression of pancreatic cancer," the authors conclude.

(JAMA. 2009;301[24]:2553-2562. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Overweight, Obesity, and Pancreatic Cancer - Beyond Risk Alone

In an accompanying editorial, Robert R. McWilliams, M.D., and Gloria M. Petersen, Ph.D., of Mayo Clinic, Rochester, Minn., comment on the findings regarding BMI and risk of pancreatic cancer.

"The study by Li et al represents an incremental advance in the understanding of clinical factors contributing to pancreatic cancer development and progression. In particular, the survival analyses illustrate how epidemiological studies that include retrospe
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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
JAMA and Archives Journals
Source:Eurekalert

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