Navigation Links
Being overweight, obese during early adulthood associated with greater risk of pancreatic cancer

Young adults who are overweight or obese have an increased risk of pancreatic cancer, and being obese at an older age is associated with a lower overall survival rate for patients with pancreatic cancer, according to a study in the June 24 issue of JAMA.

Pancreatic cancer is the fourth leading cause of cancer-related death for both men and women in the United States. As the prevalence of overweight and obesity have rapidly increased during the last 2 decades, accumulating evidence has emerged that excess body weight is a risk factor for pancreatic cancer. "However, to our knowledge, no study has explicitly reported the association between excess body weight across an individual's life span and the risk of pancreatic cancer or identified at which ages the key predisposing weight change usually occurs," the authors write.

Donghui Li, Ph.D., of the University of Texas M. D. Anderson Cancer Center, Houston, and colleagues conducted a study to determine the associations between body mass index (BMI) over a lifetime and pancreatic cancer risk, age at onset, and overall patient survival. The study included 841 patients with pancreatic cancer and 754 healthy individuals matched by age, race, and sex. Height and body weight histories were collected by personal interview starting at ages 14 to 19 years and over 10-year intervals progressing to the year prior to recruitment in the study.

The researchers found that individuals who were overweight (a BMI of 25-29.9) from the ages of 14 to 39 years or obese (a BMI of 30 or greater) from the ages of 20 to 49 years had an associated increased risk of pancreatic cancer, independent of diabetes status. The association between average BMI (per 5-unit increase) and risk of pancreatic cancer was stronger in men than in women. The association was statistically significant for each age group from 14 to 69 years in men but only from ages 14 to 39 years in women. The estimated association of average BMI (per 5-unit increase) with cancer risk also was slightly stronger in ever smokers than in never smokers. It was estimated that 10.3 percent of never smokers and 21.3 percent of ever smokers had pancreatic cancer attributable to being overweight or obese at an early age prior to cancer diagnosis (i.e., from the ages of 14-59 years).

Individuals who were overweight or obese from the ages of 20 to 49 years had an earlier onset of pancreatic cancer by 2 to 6 years (median [midpoint] age of onset was 64 years for patients with normal weight, 61 years for overweight patients, and 59 years for obese patients). Compared with those with normal body weight and after adjusting for all clinical factors, individuals who were overweight or obese from the ages of 30 to 79 years or in the year prior to recruitment had reduced overall survival of pancreatic cancer regardless of disease stage and tumor resection status.

"While our observations require confirmation, they provide support for a role of excess body weight in the development and progression of pancreatic cancer," the authors conclude.

(JAMA. 2009;301[24]:2553-2562. Available pre-embargo to the media at

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Overweight, Obesity, and Pancreatic Cancer - Beyond Risk Alone

In an accompanying editorial, Robert R. McWilliams, M.D., and Gloria M. Petersen, Ph.D., of Mayo Clinic, Rochester, Minn., comment on the findings regarding BMI and risk of pancreatic cancer.

"The study by Li et al represents an incremental advance in the understanding of clinical factors contributing to pancreatic cancer development and progression. In particular, the survival analyses illustrate how epidemiological studies that include retrospective information gathering, combined with prospective follow-up, are helpful in establishing survival factors outside of the clinical trial setting. The biological bases for how overweight and obesity contribute to younger age of diagnosis, increased risk for pancreatic cancer, and poorer survival in pancreatic cancer require further investigation. Understanding these associations will provide much needed clues for targeting potential preventive and therapeutic strategies for this extremely aggressive and resistant type of cancer."


Contact: Scott Merville
JAMA and Archives Journals

Related medicine news :

1. Drug That Lowers Resting Heart Rate Being Tested
2. Study finds some kids are being misdiagnosed with asthma
3. What is Being Done to Prevent Misdiagnosis?
4. Ricki Lakes New Movie, The Business of Being Born Promoted by Local Mom-Roots Campaign
5. American Heart Association Congratulates Pioneer Heart Surgeon for Being Named Recipient of Congressional Gold Medal Award
6. New IOF Report Shows Smoking, Alcohol, Being Underweight and Poor Nutrition Harm Our Bones
7. Being a Condom Tester is a Hard Job
8. Penn researchers find emotional well-being has no influence on cancer survival
9. Many at Risk for HIV Not Being Tested
10. Report shows less than half of kids in California are being read to daily
11. Living arrangements, health and well-being: A European perspective
Post Your Comments:
(Date:11/29/2015)... ... November 30, 2015 , ... Gift ... company, Sublime Beauty NATURALS®. All products are available on Amazon or its webstore. ... organic facial serums and USDA Certified Organic Sesame Oil for Oil Pulling," says ...
(Date:11/29/2015)... ... 2015 , ... NewsWatch featured X-wing as part of its monthly Tech Report, ... technology expert and special reporter for NewsWatch, conducted the review and shared with viewers ... the future because flying cars are about to become a reality. Where’s the idea ...
(Date:11/29/2015)... ... November 29, 2015 , ... ProStatic Analog Distortion from ... designed specially for Final Cut Pro X. FCPX users can now ... modification controls. Destoying and creating chaotic distortion is now quick and simple, putting ...
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... Safe storage ... creativity of two inventors, one from Lakewood, New Jersey and the other from Bradley ... the patent-pending PROTECTOR to save the expense of having to replace NuvaRings more often ...
(Date:11/27/2015)... ... November 28, 2015 , ... There is only one major question facing all ... year? , This question has not been an easy question to answer. Especially when ... and the younger workforce don’t share the same discipline around working long hours. ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... -- The GE Health Cloud 1 was unveiled today at ... North America (RSNA) meeting in Chicago ... cloud ecosystem and its applications will connect radiologists and clinicians ... teams – both inside and outside the hospital setting. ... "As the digital industrial leader, we are betting big on ...
(Date:11/27/2015)... Une nouvelle approche consistant ... contre le cancer avancé.    --> ... au traitement photodynamique au Bremachlorin contre le cancer ... nouvelle approche consistant à combiner l,immunothérapie au traitement ...    Clinical Cancer Research . ...
(Date:11/27/2015)... , Nov. 27, 2015  Lannett Company, ... it has completed the acquisition of Kremers Urban ... subsidiary of global biopharmaceuticals company UCB S.A. (Euronext: ... Lannett has acquired KU from UCB for ... certain adjustments, including a customary working capital adjustment, ...
Breaking Medicine Technology: