Navigation Links
Bees shed light on human sweet perception and metabolic disorders
Date:6/29/2012

TEMPE, Ariz. Scientists at Arizona State University have discovered that honey bees may teach us about basic connections between taste perception and metabolic disorders in humans. By experimenting with honey bee genetics, researchers have identified connections between sugar sensitivity, diabetic physiology and carbohydrate metabolism. Bees and humans may partially share these connections.

In a study published in the open-access journal PLoS Genetics (Public Library of Science), Gro Amdam, an associate professor, and Ying Wang, a research scientist, in the School of Life Sciences in ASU's College of Liberal Arts and Sciences, explain how for the first time, they've successfully inactivated two genes in the bees' "master regulator" module that controls food-related behaviors. By doing so, researchers discovered a possible molecular link between sweet taste perception and the state of internal energy.

"A bee's sensitivity to sugar reveals her attitude towards food, how old the bee is when she starts searching for nectar and pollen, and which kind of food she prefers to collect," said Wang, lead author of the paper. "By suppressing these two 'master' genes, we discovered that bees can become more sensitive to sweet taste. But interestingly, those bees also had very high blood sugar levels, and low levels of insulin, much like people who have Type 1 diabetes."

In Amdam's honey bee lab at ASU, scientists suppressed two genes including vitellogenin, which is similar to a human gene called apolipoprotein B, and ultraspiracle, which partners with an insect hormone that has some functions in common with the human thyroid hormone. The team is the first in the world to accomplish this double gene-suppressing technique. Researchers used this method to understand how the master regulator works.

"Now, if one can use the bees to understand how taste perception and metabolic syndromes are connected, it's a very useful tool," said Amdam, who also has a honey bee laboratory at the Norwegian University of Life Sciences. "Most of what we know about deficits in human perceptions is from people who are very sick or have had a brain trauma. We know shockingly little about people in this area."

The researchers are now considering how, exactly, the bees' sweet taste was enhanced by the experiment. The most metabolically active tissue of the bee, called the fat body, may hold the key. The fat body is similar to the liver and abdominal fat in humans, in that it helps store nutrients and create energy.

Amdam explains that taste perception evolved as a survival mechanism, for bees as well as for people. For example, bitter foods may be poisonous or sweet taste may signal foods rich in calories for energy. For all animals, taste perception must communicate properly with one's internal energetic state to control food intake and maintain normal life functions. Without this, poorly functioning taste perception can contribute to unhealthy eating behaviors and metabolic diseases such as diabetes and obesity.

"From this study, we realized we can take advantage of honey bees in understanding how food-related behaviors interact with internal metabolism, as well as how to manipulate these food-related behaviors in order to control metabolic disorders," added Amdam.


'/>"/>

Contact: Sandra Leander
sandra.leander@asu.edu
480-965-9865
Arizona State University
Source:Eurekalert  

Related medicine news :

1. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
2. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
3. Scientific session and new research highlights
4. U.S. Gives Green Light to Publish Controversial Bird Flu Research
5. Shedding light on southpaws
6. Intense light prevents, treats heart attacks
7. Triple negative breast cancer symposium highlights current advances
8. With Weights, You Can Lighten Your Load
9. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
10. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
11. Study Links Antibiotic to Slight Rise in Heart Patients Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bees shed light on human sweet perception and metabolic disorders
(Date:5/25/2016)... , ... May 25, 2016 , ... Casa Velas, an ... properties of precious stones to complement its new wellness suites . The two ... and feature a plethora of special services and insuite amenities, from a custom soap ...
(Date:5/25/2016)... , ... May 25, 2016 , ... America Walks ... Carol Reichbaum, M.S.L., M.S.P.A., of the University of Pittsburgh Graduate School of Public ... will enable Ms. Reichbaum and 24 other advocates from around the country to participate ...
(Date:5/25/2016)... ... 2016 , ... "FCPX LUT Intense allows users to cycle through different high-contrast ... CEO of Pixel Film Studios. , With the FCPX LUT Intense Plugin ... to their footage. A LUT is a Lookup Table that contains a mathematical formula ...
(Date:5/25/2016)... ... May 25, 2016 , ... Consumer access to organic ... June 2016, Kashi®, a maker of whole grain cereals and other plant-based foods, will ... ingredient: hard red winter wheat processed by Hesco/Dakota Organic Products. , The transitional ...
(Date:5/25/2016)... New Jersey (PRWEB) , ... May 25, 2016 , ... ... specialized technology firm will be selling the device branded as Stern’s Real Time ... is geared to bedbugs to the hotel and motel industry, colleges for use in ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016   , Study ... overall bowel cleansing and superiority in , ... of the ascending colon ... Norgine B.V. today announced new positive data from the ... bowel preparation) versus standard 2 litre PEG with ascorbate. The study ...
(Date:5/24/2016)... N.J. , May 24, 2016 ... oncology drug development company, today provided an update ... dose escalating clinical trial combining GEN-1, the Company,s ... the treatment of newly-diagnosed patients with advanced ovarian ... interval debulking surgery.  GEN-1 is an IL-12 DNA ...
(Date:5/24/2016)... , May 24, 2016 ... ™ , la première endoprothèse ... cathéters destinés à l,intervention portant sur les ...   OrbusNeich, entreprise mondiale spécialisée ... de changer la vie, a élargi son ...
Breaking Medicine Technology: