Navigation Links
Beer Ingredient Eyed in Prostate Cancer Prevention
Date:12/9/2009

But experiments in rats should not encourage guys to drink up, experts say

WEDNESDAY, Dec. 9 (HealthDay News) -- An ingredient of beer may someday help ward off prostate cancer, new animal experiments suggest.

The compound in question, xanthohumol, is found in hops -- the bitter flavoring agent in beer -- and is known to block the male hormone testosterone, which plays a role in the development of prostate cancer.

"We hope that one day we can demonstrate that xanthohumol prevents prostate cancer development, first in animal models and then in humans, but we are just at the beginning," said lead researcher Clarissa Gerhauser, group leader of cancer chemoprevention in the division of epigenomics and cancer risk factors at the German Cancer Research Center in Heidelberg.

The findings were to be presented Dec. 9 at a conference of the American Association for Cancer Research in Houston.

Xanthohumol is a flavonoid, a group found in many plants, fruits, vegetables and spices. Studies of xanthohumol have shown that it blocks estrogen by binding to its receptor, which may lead to prevention of breast cancer, the researchers say. It's known that estrogen and testosterone receptors react in similar ways.

For this study, Gerhauser's team started with hormone-dependent prostate cancer cells and stimulated them with testosterone, which led to a massive secretion of prostate specific antigen (PSA).

"When we treated the cells together with testosterone and xanthohumol, PSA secretion was inhibited, and this was dependent on the dose of xanthohumol," Gerhauser said.

In additional experiments, the researchers found that xanthohumol binds with the receptor, preventing it from producing PSA.

Gerhauser's group found that when xanthohumol and testosterone were injected into castrated rats, xanthohumol blocked the effect of testosterone on the prostate, which potentially could lead to preventing prostate cancer.

"Although the prostate weights were not changed, xanthohumol still reduced the effects of hormone signaling, such as gene expression, measured in the prostate tissue," she said.

"Xanthohumol is a natural product, which blocks the effects of male hormone testosterone, and should therefore be investigated for prostate cancer prevention," she said.

Not everyone believes that beer looks like a potential solution to this disease, which affects one out of six American men and will kill more than 27,000 of them this year, according to the American Cancer Society.

Dr. Durado Brooks, director of prostate and colorectal cancer at the American Cancer Society, said that if beer could prevent prostate cancer, we would already see lower rates of it.

"Like a lot of findings, it's way too early. Showing that something works in a test tube and that you can impact rat prostates is a long way from demonstrating any sort of viability in humans," he said.

A better bet for men might be the drug finasteride (Proscar), which has been shown to reduce the risk of developing prostate cancer, Brooks said.

"Men need to understand that these drugs are not risk-free, but if a man is concerned about his prostate cancer risk then he should be aware that there are medicines out there that have been shown to be efficacious in decreasing the risk," he said.

Drinking a lot of beer is "not one of the things we recommend," Brooks said.

More information

For more information on prostate cancer, visit the American Cancer Society.



SOURCES: Clarissa Gerhauser, Ph.D., group leader, cancer chemoprevention, division of epigenomics and cancer risk factors, German Cancer Research Center, Heidelberg; Durado Brooks, M.D., director, prostate and colorectal cancer, American Cancer Society, Atlanta; Dec. 9, 2009, presentation, American Association for Cancer Research conference, Houston


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Reportlinker Adds Key Players and Innovative Start-Ups in Nutraceuticals: Emerging Strategies in Ingredients, Pharma, Food and Drinks
2. Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers
3. Main Ingredients in Household Dust Come From Outdoors
4. Reportlinker Adds US World Nutraceutical Ingredients Industry
5. Vaporized Propylene Glycol, a Key Ingredient in Electronic Cigarettes, May Prevent Pneumonia, Influenza, and Other Respiratory Diseases
6. InVitria's Better Ingredients for Better Media to be Showcased at BPI '09
7. Video: Laughter is the Key Ingredient in FIZZYS LUNCH LAB, a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org
8. Pharmacies Use Online Database to Stop the Sale of Illegal Amounts of Key Ingredient Used to Make Methamphetamines
9. Frost & Sullivan Honours Kemin Health With Global Weight Management Ingredients New Product Innovation Award
10. Frost & Sullivan Global Heart Health Ingredients Excellence in Financial & Risk Management Award Conferred on Pronova BioPharma
11. Reportlinker Adds World Markets for Fermentation Ingredients Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... HEALTHCAREfirst , the leading ... and Deyta Analytics, recently announced the recipients of the fourth annual Hospice Honors, ... measured from the caregiver’s point of view. The official list of recipients was ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... Duchenne muscular dystrophy, and funding for Duchenne research, participated in the April 25 ... Sarepta Therapeutic’s novel Duchenne drug eteplirsen. The meeting at the Marriott Conference Center ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intellitec ... company’s use of Microsoft Dynamics GP for one their long-term care clients. Working ... integrated Dynamics GP with key clinical management systems, and delivered a fully integrated ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... will be held May 16th to 18th at the Broward County Convention Center. ... managed facilities to collaborate on best practices in public facility management. Intellitec Solutions ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Society for Assisted ... endocrinologists are required to report in vitro fertilization (IVF) delivery rates ... the practice of assisted reproductive technologies in the United States. , This ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... BERLIN , April 29, 2016 ... world-leading glyco-biology expertise, today announces the appointment of Dr. ... Dr. Zurlo is an oncologist with many years ... pharmaceutical and biotechnology industries. His last role was at ... Member of the Executive Board. Previously Dr. Zurlo held ...
(Date:4/29/2016)... 2016 Automation is one of ... to the growing demands for productivity in speed, accuracy, ... systems are already adept of a wide range of ... manual labor. Instrumentation continues to evolve, and is poised ... a few years ago. Originally used mostly by the ...
(Date:4/28/2016)... Mich. , April 28, 2016   ... . Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s ... has signed a definitive agreement to acquire Valley ... Specialty Pharmacy ("TNH"), a leading specialty pharmacy that ... Van Nuys, California . In 2015, TNH ...
Breaking Medicine Technology: