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Beaumont, U-M Open Study of Drug for Advanced Breast Cancer
Date:10/28/2009

ticipants are randomly assigned to study groups and will know which treatment regimen they are receiving. Women initially assigned to the group that does not receive the study drug will have the opportunity to receive the study drug if their disease worsens during treatment with chemotherapy alone. This trial is underway at multiple sites throughout the country and is expected to conclude enrollment by the end of the year.

To participate in the trial, patients must have:

 
  • a diagnosis of metastatic TNBC
  • completed no more than two rounds of chemotherapeutic treatments for metastatic disease
  • disease that is measurable on an imaging study
"The PARP inhibitors represent a novel cancer treatment that holds great promise for many patients with cancer," says Dana Zakalik, M.D., director of the Beaumont Cancer Genetics Program and principal investigator at Beaumont. "They provide hope for patients with this particularly aggressive breast cancer for whom conventional treatments were lacking."

Triple negative breast cancer is a subtype of breast cancer that accounts for about one in five breast cancer diagnoses. Subtypes of breast cancer are based on the presence of three receptors that are known to fuel tumor growth and spread of cancer. These receptors are estrogen, progesterone and human epidermal growth factor or HER2. Existing therapies bind to or otherwise inhibit the receptors, thus impeding tumor growth. In TNBC, none of these
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