Navigation Links
Bcl6 gene sculpts helper T cell to boost antibody production
Date:7/23/2009

HOUSTON - Expression of a single gene programs an immune system helper T cell that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune diseases and development of B cell lymphoma, scientists at The University of Texas M. D. Anderson Cancer Center reported today in Science Express, the advance online publication of the journal Science.

The gene is Bcl6, which the team found plays the crucial role in differentiating a nave T cell into a T follicular helper cell (Tfh).

"Tfh cells were first noticed in structures called germinal centers found in the lymphoid system - in lymph nodes and the spleen," said senior author Chen Dong, Ph.D., professor in M. D. Anderson's Department of Immunology. Germinal centers are powerful machines that churn out lots of antibodies.

In the adaptive immune system, B cells present an antigen - a distinctive piece of an invading bacterium or virus - to T cells. The bound antigen converts a nave T cell to a helper T cell that secretes cytokines which help the B cells expand and produce a large volume of antibodies to destroy an intruder.

Tfh cells are concentrated with B cells in germinal centers, where they play a helper T cell's traditional role in B cell proliferation and antibody development.

"In germinal centers, the B cells not only proliferate but they also undergo hypermutation in their immunoglobulin genes so they can produce a diverse class of antibodies," Dong said. "These mutations also allow production of antibodies with stronger affinity for their target antigens."

There are pitfalls to this process. Tfh cells and germinal centers have been implicated in antibody-mediated autoimmune diseases such as lupus and rheumatoid arthritis, Dong noted. In these diseases, the germinal centers are likely producing the wrong type of antibody at great volume.

Genetic hypermutation among B cells in germinal centers
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nations Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers
2. Natures helpers: Using microorganisms to remove TCE from water
3. Nightingale announces US$12.3 million sale of its Therapist Helper business
4. Ceridian LifeWorks Offers CareGiverHelper Service to Clients to Ease Stress of Family Caregiving
5. Home Helpers and Veterans Express Helping Spread the Word About Little-Known Veteran's Aid and Attendance Benefit
6. Netsmart Technologies Releases Version 7.5 of Helper(TM) Practice Management Software
7. Netsmart Technologies Releases Version 7.5 Of Helper™ Practice Management Software
8. New treatment boosts muscle function in myasthenia gravis
9. Heavy Drinking Boosts Stroke Risk for Chinese Men
10. Longer ambulance journeys boost death risk for seriously ill patients
11. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... (PRWEB) December 26, 2014 It is said ... great dress. Today, UWDress.com, the famous wedding dress supplier, ... launches a site-wide cocktail gown promotion. , UWDress.com’s navy ... collection, and they come in high fashion styles. Simple dresses ... depending on the occasion; they are specially designed for those ...
(Date:12/26/2014)... 26, 2014 “Many people become overwhelmed ... injury claim issues and phone calls with insurance companies,” ... article featuring their free eBook on pedestrian and ... on pedestrian and bicycle auto accident claims assures the ... capable of professionally handling their case while they focus ...
(Date:12/25/2014)... 26, 2014 The microscopy market ... 7.2% to reach $5,756.0 million by 2019. Optical ... market. The electron microscopes product segment is expected ... period. , Rising focus on nanotechnology, technological advancements, ... the microscopy market. , Get Full Copy of ...
(Date:12/25/2014)... York (PRWEB) December 25, 2014 Product ... DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to ... According to an Order issued in the U.S. District ... Court will convene an open conference on January 7, ... United States Courthouse in West Palm Beach, Florida. The ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Recently, ... discounts on all its wedding dresses. BellasDress has chosen ... more for gift choices for the holiday season. ... can pick suitable wedding gowns here at discount prices. ... shopping experience at its website. , “All ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... , FRIDAY, Jan. 14 (HealthDay News) -- Bacteria that prey ... say U.S. researchers. They tested two types of predatory ... -- on dozens of other bacteria. "They actually ... life cycles. They have a great ability to seek out ...
... , FRIDAY, Jan. 14 (HealthDay News) -- Remember the intensity ... years, the never-ending housework and the demands of raising a ... spouse? New research using brain scans suggests some married ... or more. When gazing at a photo of their ...
... Intensive early education programs for low-income children have been ... have looked more broadly at their impact on health ... at Columbia University,s Mailman School of Public Health examines ... Abecedarian Project (ABC), a randomized control study that enrolled ...
... FRIDAY, Jan. 14 (HealthDay News) -- Internal medicine residents ... care doctors, who are expected to be in greater ... study from Johns Hopkins. They,re unprepared to care ... hypertension and high cholesterol, the study says, though they ...
... E. coli uses a laser to detect and ... waterways. The technique described this month in the International ... the incidence of waterborne disease outbreaks. Microbial contamination of ... diseases are the leading causes of illness and death in ...
... blood pressure, according to new research by the University of ... or hypertension is one of the major cardiovascular ... costs more than $300 billion each year. Around a quarter ... million people in the UK and one in three US ...
Cached Medicine News:Health News:Predatory Bacteria May Help Control Antibiotic-Resistant Germs 2Health News:Brain Scans Show Married Love Can Last 2Health News:Brain Scans Show Married Love Can Last 3Health News:Enhanced early childhood education pays long-term dividends in better health 2Health News:Med School Grads May Not Be Ready for Primary Care 2Health News:Speeding up E. coli detection 2Health News:Bioactive compounds in berries can reduce high blood pressure 2
(Date:12/24/2014)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ), ... announce Jennifer Hagerman , Pharm.D., AE-C, senior director ... as the president of the Michigan Pharmacists Association on ... place Feb. 28, 2015, at the MPA Annual Convention ... Center in Detroit, Michigan . Hagerman ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
(Date:12/24/2014)... , Dec. 23, 2014   Synageva ... a biopharmaceutical company developing therapeutic products for rare ... Agency (EMA) of the Marketing Authorization Application (MAA) ... recently granted the company,s request for accelerated assessment, ... regulatory review time.   The MAA, ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... Penile Prosthesis (IPP) is a ... surgically implanted into the penis ... dysfunction (also known as impotence). ... with voluntary control over the ...
... Positionable Penile Prosthesis,The ... prosthesis is made of ... core strength that gives ... most: ease of positioning, ...
... AMS Ambicor is a uniquely designed two-piece ... cylinders implanted in the corpora cavernosa and ... scrotum. Patients simply squeeze the pump to ... the prosthesis. This closed, fluid-filled system allows ...
Only Mentors reusable Alpine Leg Bag has patented Kraylex odor barrier, offset port options, and integrated loops providing total confidence and comfort....
Medicine Products: