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Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
Date:10/23/2007

uses microarrays to capture up to 6,500 human gene parts, or exons, for sequence analysis, reducing the dependence on large-scale polymerase chain reaction.

With this combination of 454 and NimbleGen methods, we have an unprecedented ability to detect changes across the human genome, said Gibbs.

The new Genome Sequencer FLX systems will also be applied to the analysis of bacterial genomes in a National Institutes of Health supported effort to analyze metagenomes collections of bacteria that live in human hosts both normally and in infectious disease.

The GS FLX system has been remarkably successfulnot only for human medical resequencingbut also for microbial genome sequencing. Expanding our sequencing capabilities with the additional systems figures prominently in our plans for the Human Microbiome Project, said George Weinstock, co-Director and leader of its Microbial Genomics Programs for the Human Genome Sequencing Center at Baylor College of Medicine.

In addition to the purchase agreement, the Human Genome Sequencing Center and Roche also expanded their prior collaboration. The center will obtain early access to next generation updates to the Genome Sequencer FLX system. The system improvements will include an increase in sequence read length beyond 400 base pairs. The net result will be a sequencing solution that generates more than 1 billion bases per day. Other updates focus on improvements that make it easier to routinely sequence human genomes. These system improvements include enhancements in the reagents and software, utilizing the same hardware configuration that is currently available and purchased as part of this agreement.


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Contact: Lori McLaughlin
lori.mclaughlin@roche.com
317-521-3112
Roche
Source:Eurekalert

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