Navigation Links
Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
Date:10/23/2007

INDIANAPOLISThe Human Genome Sequencing Center at Baylor College of Medicine boosted its sequencing capabilities with an agreement to acquire seven additional Genome Sequencer FLX Systems from 454 Life Sciences, a Roche company.

With 10 Genome Sequencer FLX Systems, the Human Genome Sequencing Center will be in a unique position to apply 454 Life Sciences technologies to problems ranging from the deciphering of new genomes to the analysis of mutations associated with human diseases.

These instruments previously proved their capabilities in the arena of whole genome sequencing, said Richard Gibbs, Professor and Director of the Human Genome Sequencing Center at Baylor College of Medicine, a former member of the 454 Life Sciences Scientific Advisory Board until March 2007. Now they have demonstrated their potential role in large scale mutation detection.

To better understand genetic basis for disease - including cancer, heart disease, and asthma - genomic information from large numbers of individuals need to be analyzed in a rapid and cost-effective manner. Rapid DNA sequencing technologies allow researchers to identify all genetic changes when comparing healthy individuals to those with disease.

This purchase helps demonstrate that the GS FLX is a proven technology with nearly 100 published peer-review articles, said Lonnie Shoff, Senior Vice President of Molecular Diagnostics and Applied Science for Roche Diagnostics. We see the GS FLX being used in production sequencing due to the systems scalability to support both small and very large projects, along with the instruments durability, which allows it to be run continuously.

These efforts using the Genome Sequencer FLX are further enhanced by a collaboration with the Human Genome Sequencing Center at Baylor College of Medicine and another Roche company, Roche NimbleGen. Preliminary work from the collaboration was reported in Nature Methods this week, and uses microarrays to capture up to 6,500 human gene parts, or exons, for sequence analysis, reducing the dependence on large-scale polymerase chain reaction.

With this combination of 454 and NimbleGen methods, we have an unprecedented ability to detect changes across the human genome, said Gibbs.

The new Genome Sequencer FLX systems will also be applied to the analysis of bacterial genomes in a National Institutes of Health supported effort to analyze metagenomes collections of bacteria that live in human hosts both normally and in infectious disease.

The GS FLX system has been remarkably successfulnot only for human medical resequencingbut also for microbial genome sequencing. Expanding our sequencing capabilities with the additional systems figures prominently in our plans for the Human Microbiome Project, said George Weinstock, co-Director and leader of its Microbial Genomics Programs for the Human Genome Sequencing Center at Baylor College of Medicine.

In addition to the purchase agreement, the Human Genome Sequencing Center and Roche also expanded their prior collaboration. The center will obtain early access to next generation updates to the Genome Sequencer FLX system. The system improvements will include an increase in sequence read length beyond 400 base pairs. The net result will be a sequencing solution that generates more than 1 billion bases per day. Other updates focus on improvements that make it easier to routinely sequence human genomes. These system improvements include enhancements in the reagents and software, utilizing the same hardware configuration that is currently available and purchased as part of this agreement.


'/>"/>

Contact: Lori McLaughlin
lori.mclaughlin@roche.com
317-521-3112
Roche
Source:Eurekalert

Related medicine news :

1. Grant of $7 million for Orissa Medical College from Japan
2. Orissa To Get New Medical Colleges Soon
3. Kottayam Medical College To be Upgraded
4. Kasturba Medical College Organizes CME- Orth 2005 From 4th To 6th November
5. Disadvantaged Students May Not Go In For College Education
6. Medical College Construction At Raichur Makes Slow Progress
7. Risk Attitudes And Consequences Of College Drinking
8. Call Of The Wild: Heard Of Spring Drinking? Ask The College Girls, Who Are Getting Freaked Out
9. Calcutta National Medical College Strike Continues Unabated
10. Medical Colleges, Confident of Meeting Standards Before 90-days deadline
11. Ignorance about AIDS rampart in Third of College Students: Chinese survey
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 29, 2017 , ... Dr. Angela Cotey, a noted general ... accepting new pediatric patients, with or without a referral. Dr. Cotey knows that ... orthodontic outcome and experience. When patients receive early treatment, they may achieve straight teeth ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... buildings (MOBs) and other outpatient facilities, and who are the most active developers? ... those questions, Revista and Healthcare Real Estate Insights (HREI) found that outpatient medical ...
(Date:3/29/2017)... ... , ... Curio Wellness , a premium medical cannabis brand and trusted ... management team with prominent executives from both inside and outside the cannabis industry. ... Ted Dumbauld , who has more than twenty years of business leadership and investment ...
(Date:3/29/2017)... ... March 29, 2017 , ... HealthCareMandA.com will host an important webinar ... at 1:00 PM ET. A recording of the webinar will also be made available ... Home health and hospice companies are still popular targets for healthcare investors. This highly ...
(Date:3/29/2017)... ... 2017 , ... Immunotherapy has emerged as one of the most promising options ... be the next revolution in our fight against this complex disease. One of the ... checkpoint inhibitors such as PD-1 and PD-L1 inhibitors. , While a few single analyte ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Calif. , March 29, 2017  Experts ... recognized remote monitoring devices like  Soberlink Systems  as ... The consensus paper, published in early 2017, concluded ... and valuable in managing patient recovery." ... the Journal of Addiction Medicine, detail a range ...
(Date:3/29/2017)... , March 29, 2017  Glenmark Pharmaceuticals, ... for GSP 301, an investigational fixed-dose combination of ... mcg) administered twice-daily as a nasal spray being ... These results are from a recently completed Phase ... GSP 301 combination therapy versus mometasone, olopatadine or ...
(Date:3/29/2017)... , Mar. 29, 2017 Research and ... Market 2017-2021" report to their offering. ... The global lifestyle drugs market to ... The report, Global Lifestyle Drugs Market 2017-2021, has been ... experts. The report covers the market landscape and its growth prospects ...
Breaking Medicine Technology: