Navigation Links
Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
Date:10/23/2007

INDIANAPOLISThe Human Genome Sequencing Center at Baylor College of Medicine boosted its sequencing capabilities with an agreement to acquire seven additional Genome Sequencer FLX Systems from 454 Life Sciences, a Roche company.

With 10 Genome Sequencer FLX Systems, the Human Genome Sequencing Center will be in a unique position to apply 454 Life Sciences technologies to problems ranging from the deciphering of new genomes to the analysis of mutations associated with human diseases.

These instruments previously proved their capabilities in the arena of whole genome sequencing, said Richard Gibbs, Professor and Director of the Human Genome Sequencing Center at Baylor College of Medicine, a former member of the 454 Life Sciences Scientific Advisory Board until March 2007. Now they have demonstrated their potential role in large scale mutation detection.

To better understand genetic basis for disease - including cancer, heart disease, and asthma - genomic information from large numbers of individuals need to be analyzed in a rapid and cost-effective manner. Rapid DNA sequencing technologies allow researchers to identify all genetic changes when comparing healthy individuals to those with disease.

This purchase helps demonstrate that the GS FLX is a proven technology with nearly 100 published peer-review articles, said Lonnie Shoff, Senior Vice President of Molecular Diagnostics and Applied Science for Roche Diagnostics. We see the GS FLX being used in production sequencing due to the systems scalability to support both small and very large projects, along with the instruments durability, which allows it to be run continuously.

These efforts using the Genome Sequencer FLX are further enhanced by a collaboration with the Human Genome Sequencing Center at Baylor College of Medicine and another Roche company, Roche NimbleGen. Preliminary work from the collaboration was reported in Nature Methods this week, and uses microarrays to capture up to 6,500 human gene parts, or exons, for sequence analysis, reducing the dependence on large-scale polymerase chain reaction.

With this combination of 454 and NimbleGen methods, we have an unprecedented ability to detect changes across the human genome, said Gibbs.

The new Genome Sequencer FLX systems will also be applied to the analysis of bacterial genomes in a National Institutes of Health supported effort to analyze metagenomes collections of bacteria that live in human hosts both normally and in infectious disease.

The GS FLX system has been remarkably successfulnot only for human medical resequencingbut also for microbial genome sequencing. Expanding our sequencing capabilities with the additional systems figures prominently in our plans for the Human Microbiome Project, said George Weinstock, co-Director and leader of its Microbial Genomics Programs for the Human Genome Sequencing Center at Baylor College of Medicine.

In addition to the purchase agreement, the Human Genome Sequencing Center and Roche also expanded their prior collaboration. The center will obtain early access to next generation updates to the Genome Sequencer FLX system. The system improvements will include an increase in sequence read length beyond 400 base pairs. The net result will be a sequencing solution that generates more than 1 billion bases per day. Other updates focus on improvements that make it easier to routinely sequence human genomes. These system improvements include enhancements in the reagents and software, utilizing the same hardware configuration that is currently available and purchased as part of this agreement.


'/>"/>

Contact: Lori McLaughlin
lori.mclaughlin@roche.com
317-521-3112
Roche
Source:Eurekalert

Related medicine news :

1. Grant of $7 million for Orissa Medical College from Japan
2. Orissa To Get New Medical Colleges Soon
3. Kottayam Medical College To be Upgraded
4. Kasturba Medical College Organizes CME- Orth 2005 From 4th To 6th November
5. Disadvantaged Students May Not Go In For College Education
6. Medical College Construction At Raichur Makes Slow Progress
7. Risk Attitudes And Consequences Of College Drinking
8. Call Of The Wild: Heard Of Spring Drinking? Ask The College Girls, Who Are Getting Freaked Out
9. Calcutta National Medical College Strike Continues Unabated
10. Medical Colleges, Confident of Meeting Standards Before 90-days deadline
11. Ignorance about AIDS rampart in Third of College Students: Chinese survey
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)...   ZirMed Inc ., a recognized leader in cloud-based ... has been ranked #1 by its users for the seventh ... User Survey. ZirMed was recognized as the top-ranked end-to-end revenue ... centers over 200 beds and holds one of the longest ... history. ...
(Date:9/18/2017)... R.I. , Sept. 18, 2017 /PRNewswire/ ... the fields of bioinformatics and immune engineering, ... a protective avian influenza A (H7N9) vaccine. ... distantly related to seasonal influenza and presents ... rely on prior exposure to be effective. ...
(Date:9/12/2017)... Sept. 12, 2017   EcoVadis , the leading platform for environmental, ... first annual edition of its Global CSR Risk and Performance Index. The ... EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points across ... ... ...
Breaking Medicine Technology: