Navigation Links
Battle between the placenta and uterus could help explain preeclampsia
Date:10/10/2011

A battle that brews in the mother's womb between the father's biological goal to produce the biggest, healthiest baby possible vs. the mother's need to live through delivery might help explain preeclampsia, an often deadly disease of pregnancy. The fetus must be big enough to thrive, yet small enough to pass through the birth canal. In a new study, Yale researchers describe the mechanism that keeps these conflicting goals in balance.

The findings are published in the October 11, 2011 online issue of Reproductive Sciences.

The battle is waged between the mother's uterus and the baby's placenta, which is made up of cells called trophoblasts that are controlled by the father. In the study, led by Harvey J. Kliman, M.D., research scientist in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, researchers observed how the placenta tricks the mother so she doesn't attack the trophoblasts that are trying to increase the flow of her blood into the placenta. If this placental deception doesn't work the mother may develop preeclampsia, a condition that results in high blood pressure and protein in the mother's urine. The only known cure for preeclampsia is delivery of the baby.

The placenta's job is to get nutrients from the mother during pregnancy. Kliman explained that in a normal pregnancy, specialized invasive trophoblasts leave the placenta and invade the mother's tissues to attack and destroy the walls of her blood vessels. This allows the most blood possible to enter the placenta, resulting in a big baby.

But the mother's own "soldiers," called lymphocytes, are constantly looking to destroy the invasive trophoblast cells. The placenta in turn appears to trick the mother by creating a diversion to occupy her lymphocytes.

The placenta creates this diversion by secreting a protein called placental protein 13 (PP13), also known as galectin 13, into the mother's blood where it travels through her veins into the uterus below the placenta. There the PP13 leaves the veins where it triggers the mother's immune system to react and attack. The entire area around these veins becomes a mass of inflammation and dead cells, called necrosis.

"We realized that these zones of necrosis are likely occupying the mother's soldiers while the invasive trophoblasts sneak into her arteries, leading to more blood flow to the placenta and a bigger baby," said Kliman. "We believe that maintaining this balance could be the key to a healthy pregnancy free from preeclampsia."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Related medicine news :

1. Explorers Bounty Puffed Fruit Snacks Helping Parents Battle Summer Obesity
2. Battlefield camaraderie yields long-term dividends for veterans, study finds
3. Gourmet Diet Delivery Unites with First Lady's Battle Against Obesity The Fresh Diet Begins Delivering Meals to DC
4. As Health Reform Summit Looms, Battle Lines Are Drawn
5. Barcode Joins the Battle of the Bulge in New iPhone App
6. Little City Foundation Battles for Rights of Individuals with Disabilities in Springfield and Meets with Legislators Day Before Governors Budget Address
7. BATTLE links potential biomarkers to drugs for lung cancer
8. LeAnn Rimes Brings Battle With Psoriasis to Center Stage
9. KidsHealth Challenges App Developers to Battle Obesity
10. Tastier MRE: Chemistry gives battlefield chow a gourmet flare
11. Broccoli May Help Battle Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Battle between the placenta and uterus could help explain preeclampsia
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating ... , As the stress of modern life continually makes more demands on time and ... artificial stimulants can trap people in vicious high/low cycles and can also cause long ...
(Date:8/22/2017)... ... August 22, 2017 , ... Although Labor Day is not as popular ... begun providing weekend displays, and numerous households celebrate the unofficial end of summer with ... terrifying for pets. , Kris Zambo, owner of Dynamite Fireworks in ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... risk to health and safety. By learning and implementing best practices for containment ... In this webinar, attendees will gain a better understanding of a method for ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... of two plastic surgery fellows for academic year 2017-2018, Christina M. Busuito, M.D. ... have successfully completed residency in Plastic and Reconstructive Surgery. The candidate will ...
(Date:8/21/2017)... MINNEAPOLIS, MINN (PRWEB) , ... August 21, 2017 ... ... Sports Group, today announced that it has become the Official Technology Partner of ... their AES (Advanced Event Systems) volleyball software, along with providing sport ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... its Board of Directors has approved the payment of a ... 2017. The cash dividend ... October 27, 2017 to stockholders of record as of the ... dividends are subject to approval of the Board of Directors ...
(Date:8/7/2017)... 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s largest ... June 30, 2017.  All comparisons, unless otherwise noted, are to ... Second Quarter 2017 Highlights include: ... an increase of 3.5% Total prescriptions dispensed ... of 7.5% versus 7.6% Gross profit ...
(Date:8/4/2017)... ROCKVILLE, Md. , Aug. 4, 2017 ... during or shortly after a physician/patient consult has long ... industry, and was a notable focus of the largest ...  This is according to healthcare market research firm Kalorama ... of care testing (POCT) offerings or related supplies and ...
Breaking Medicine Technology: