Navigation Links
Battle between the placenta and uterus could help explain preeclampsia

A battle that brews in the mother's womb between the father's biological goal to produce the biggest, healthiest baby possible vs. the mother's need to live through delivery might help explain preeclampsia, an often deadly disease of pregnancy. The fetus must be big enough to thrive, yet small enough to pass through the birth canal. In a new study, Yale researchers describe the mechanism that keeps these conflicting goals in balance.

The findings are published in the October 11, 2011 online issue of Reproductive Sciences.

The battle is waged between the mother's uterus and the baby's placenta, which is made up of cells called trophoblasts that are controlled by the father. In the study, led by Harvey J. Kliman, M.D., research scientist in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, researchers observed how the placenta tricks the mother so she doesn't attack the trophoblasts that are trying to increase the flow of her blood into the placenta. If this placental deception doesn't work the mother may develop preeclampsia, a condition that results in high blood pressure and protein in the mother's urine. The only known cure for preeclampsia is delivery of the baby.

The placenta's job is to get nutrients from the mother during pregnancy. Kliman explained that in a normal pregnancy, specialized invasive trophoblasts leave the placenta and invade the mother's tissues to attack and destroy the walls of her blood vessels. This allows the most blood possible to enter the placenta, resulting in a big baby.

But the mother's own "soldiers," called lymphocytes, are constantly looking to destroy the invasive trophoblast cells. The placenta in turn appears to trick the mother by creating a diversion to occupy her lymphocytes.

The placenta creates this diversion by secreting a protein called placental protein 13 (PP13), also known as galectin 13, into the mother's blood where it travels through her veins into the uterus below the placenta. There the PP13 leaves the veins where it triggers the mother's immune system to react and attack. The entire area around these veins becomes a mass of inflammation and dead cells, called necrosis.

"We realized that these zones of necrosis are likely occupying the mother's soldiers while the invasive trophoblasts sneak into her arteries, leading to more blood flow to the placenta and a bigger baby," said Kliman. "We believe that maintaining this balance could be the key to a healthy pregnancy free from preeclampsia."


Contact: Karen N. Peart
Yale University

Related medicine news :

1. Explorers Bounty Puffed Fruit Snacks Helping Parents Battle Summer Obesity
2. Battlefield camaraderie yields long-term dividends for veterans, study finds
3. Gourmet Diet Delivery Unites with First Lady's Battle Against Obesity The Fresh Diet Begins Delivering Meals to DC
4. As Health Reform Summit Looms, Battle Lines Are Drawn
5. Barcode Joins the Battle of the Bulge in New iPhone App
6. Little City Foundation Battles for Rights of Individuals with Disabilities in Springfield and Meets with Legislators Day Before Governors Budget Address
7. BATTLE links potential biomarkers to drugs for lung cancer
8. LeAnn Rimes Brings Battle With Psoriasis to Center Stage
9. KidsHealth Challenges App Developers to Battle Obesity
10. Tastier MRE: Chemistry gives battlefield chow a gourmet flare
11. Broccoli May Help Battle Breast Cancer
Post Your Comments:
Related Image:
Battle between the placenta and uterus could help explain preeclampsia
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th ... Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, ... The fun run is geared towards children of all ages; it is a non-competitive, ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
Breaking Medicine Technology: