Navigation Links
Barrett's esophagus carries lower risk of malignancy than previously reported
Date:6/16/2011

Patients with Barrett's esophagus may have a lower risk of esophageal cancer than previously reported, according to a large, long-term study published online June 16 in the Journal of the National Cancer Institute.

Barrett's esophagus is a premalignant condition, and patients who have it are often advised to have regular endoscopies to watch for signs of esophageal adenocarcinoma, the most common kind of esophageal cancer in many parts of the world. But how often Barrett's esophagus progresses to cancer has not been clear. Previous estimates of the rate of progression have varied widely.

In this study, Shivaram Bhat, B.Ch., MRCP, of Queens University Belfast and colleagues prospectively followed 8,522 patients in the Northern Ireland Barrett's Esophagus Registry, one of the largest registries in the world of people with the condition. After an average follow-up time of 7 years, 79 patients were diagnosed with esophageal cancer, 16 with cancer of the gastric cardia (the part of the stomach closest to the esophagus), and 36 with precancerous changes known as high-grade dysplasia. In the entire group, the incidence of these three conditions combined was 0.22% per year. Previous studies have reported an incidence of cancer among people with Barrett's esophagus between 0.58% and 3% per year.

The researchers also looked at the incidence of cancer and high-grade dysplasia in different subgroups of patients. Men were statistically significantly more likely to progress to malignancy than women, and people age 60-69 had a higher risk than those under 50 or those age 80 and over. The highest rates of progression were among patients with low-grade dysplasia (1.40%) or specialized intestinal metaplasia (0.38%) at their initial endoscopy and biopsy.

The authors conclude that the risk of Barrett's esophagus progressing to esophageal cancer is less than previously reported and that this finding has implications for clinical practice. "Current recommendations for surveillance are based on higher estimates of cancer risk among patients with [Barrett's esophagus] than were seen in this study and therefore, they may not be justified," they write.

In an accompanying editorial, Douglas Corley, M.D., Ph.D., from Kaiser Permanente's research division in Oakland, Calif., notes that the study provides one of the first estimates of incidence of esophageal cancer in people with Barrett's esophagus from a large multicenter population.

He writes that the study provides support "for many paradigms underlying current thoughts about the management of Barrett's esophagus." For instance, people without specialized intestinal metaplasia are at relatively low risk and are less likely to benefit from surveillance or treatment while those with intestinal metaplasia are at increased risk. He notess that the increased risk "may make surveillance cost-effective if surveillance or treatment is effective (an unproved tenet to date)."

Corley adds that the study can "help inform the development of more meaningful "personalized risk scores that incorporate demographic, biochemical, and genetic factors."


'/>"/>

Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Cancer Risk With Barretts Esophagus May Be Lower Than Thought
2. Long-term follow-up shows multipolar electrocoagulation ablation effective for Barretts esophagus
3. An international study in China finds strawberries may slow precancerous growth in the esophagus
4. Treatment of Barretts esophagus may lower risk of esophageal cancer
5. Watchful waiting no longer recommended for some high-risk Barretts esophagus patients
6. Extremely obese children have 40 percent higher risk of reflux disease of esophagus
7. New endoscopic treatment may spare Barretts esophagus patients from surgery
8. Prolonging life carries more weight
9. Nationwide Health Information Network now carries public health data
10. Proton therapy carries precise, potent punch against childrens cancers
11. Proton Therapy Carries Precise, Potent Punch Against Cancers for Patients at The Children's Hospital of Philadelphia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Ellevate Network, ... in business to advocate for action towards gender equality at their inaugural Summit in ... around the globe, and reached a social audience of over 3 million. To watch ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains ... possible to save lost souls in the Philippines. “The Journey: From the Mountains to ... dedicated teacher of the Bible. She has taught all ages and currently teaches a ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa ... contributed a medical article to the newly revamped Cosmetic Town journal ... the hair transplant procedure known as Follicular Unit Extraction (FUE). , ...
(Date:10/12/2017)... ... ... Health Literacy Innovations (HLI), creator of the Health Literacy ... Patient Education Network (CPEN), an independent professional organization that shares best practices in ... , As CPEN’s strategic partner, HLI will help support CPEN members by sharing ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Calif. , Oct. 11, 2017  BioPharmX Corporation ... scientific team that developed an innovative way to use ... of the delivery of new drugs. ... Fall Clinical Dermatology Conference will show how researchers from ... Hospital, Harvard Medical School used a suite of imaging ...
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
Breaking Medicine Technology: