Navigation Links
Balancing oxaliplatin dose with neurological side effects in metastatic colon cancer
Date:2/2/2012

The drug oxaliplatin is a major reason the prognosis for metastatic colon cancer has gone from an expected survival of several months to a couple years. Unfortunately, the drug can also carry with it debilitating neurological side effects, which generally start as the sensation of pins and needles in fingers and toes and can leave patients unable to walk or dress independently.

However, "Many patients don't receive the necessary dose to try to keep their cancer in check, because their symptoms become too debilitating and their quality of life is reduced," says Andrew Weickhardt, MD, clinical fellow at the University of Colorado Cancer Center.

Weickhardt, along with Keith Wells, MD, and Wells Messersmith, MD, CU Cancer Center investigator and developmental therapeutics program co-leader, recently published a review in the Journal of Oncology that describes how to maximize the positives of this tricky balance between oxaliplatin's effects and side effects.

"Before, when patients died in a few months, these symptoms were overlooked. Now they're living two to three years and the symptoms deserve closer attention," Weickhardt says.

The review recommends two approaches, used alone or simultaneously what Weickhardt calls a "stop and go" approach, along with supplements that may mitigate the drug's neurological damage.

In the stop and go approach, a patient starts oxaliplatin along with another drug and takes both for two months. Then, the patient takes a hiatus from oxaliplatin (while continuing the first drug), and reintroduces oxaliplatin two months later or at the point of disease progression, whichever is sooner.

"After about six to nine months of total treatment, metastatic colorectal cancers tend to develop resistance to the drug," says Weickhardt. "And also, no matter what we do, after this same six to nine months of total treatment, neurological side effects start to rise." And so stop-and-go oxaliplatin dosing spreads the drug's effectiveness over the maximum possible time, with the fewest possible side effects.

Still, with this regimen, Weickhardt says that one in twenty patients experience significant nerve damage that can last for more than six months. "There's room for improvement," he says.

Though to date clinical trials of protective drugs given with oxaliplatin have been small, Weickhardt sees promise in the use of simple calcium and magnesium supplements.

"An infusion of calcium and magnesium should be used as well because they've shown some benefit and they don't do any harm," Weickhardt says. "They're popular in the community, and I'd encourage their use."


'/>"/>
Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Brain Balancing Gives Hope for Sufferers of Depression, Stress, and Insomnia at New Life Brain Center
2. Natures Peak Products Along With Company President Paul Wilkinson Were Recently Featured on Segment of Lifetime TV Networks Nationally Broadcast Show The Balancing Act
3. O2 Media's Hit Morning TV Show ‘The Balancing Act' Welcomes Atkins Nutritionals to the Program
4. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes the Arthritis Foundation to the Program
5. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes Resident Chef Jeremy Hanlon to the Program
6. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes Dexter Russell, Inc. to the Program
7. ‘The Balancing Act' and Chicken of the Sea Search for America's ‘Supercook'
8. O2 Media's Hit Morning TV Show ‘The Balancing Act' Welcomes Absolute Miracle Cream to the Program
9. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes HSA Bank to the Program
10. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes Dr. Bob Arnot to the Program
11. 'The Balancing Act' & Chicken of the Sea Search for America's 'Supercook'
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Sandbox, one of the nation’s ... in the newly created position of executive vice president, chief creative officer.     , ... the Chicago and LA offices. He reports to Nancy Finigan, president of those ...
(Date:5/3/2016)... ... ... Excessive panting in the car or cowering when new guests arrive are ... only manifests itself as trembling or ‘tail between the legs,’ but a pet ... about it,” says Dr. Jim Lowe, technical services veterinarian for Tomlyn pet health products ...
(Date:5/3/2016)... Boston, MA (PRWEB) , ... May 03, 2016 , ... ... where clinicians can rehearse tough medical situations or practice tricky or rare procedures in ... Longwood Medical Area, the SIM Center is also available to inventors and “hackers” to ...
(Date:5/3/2016)... CA (PRWEB) , ... May 03, 2016 , ... Ogawa ... with its user friendly Samsung tablet and exclusive Smart Application. The Smart 3D ... massage. Starting each massage with a customized user profile and specialized massage program, each ...
(Date:5/3/2016)... ... May 03, 2016 , ... Octo Consulting ... and digital consulting services to the federal government, has been awarded a $9.9 ... Indefinite Quantity (ID/IQ) contract in support of the U.S. Army Program Executive Office ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... -- Pharmaceutical giant Johnson & Johnson has ... who says its talc-based powder products caused ovarian cancer. ... $5 million in compensatory damages and $50 million in ... ) , This is the second in ... the same court awarded $72 million to the family ...
(Date:5/3/2016)... Intec Pharma Ltd. (NASDAQ: ... today announced the appointment of Pnina Strauss-Levy ... "Ms. Strauss-Levy has 15 years of experience in clinical ... track record, having supported the advancement of several products ... the United States and ...
(Date:5/3/2016)... 2016 Norgine B.V. ... einen entscheidenden Meilenstein durch diese Veröffentlichung zur  ... Handeln, um Patientenresultate  bei Verdauungs- und Lebererkrankungen ... im Verständnis der Hepatischen Enzephalopathie bei und ... Hepatische Enzephalopathie in der Öffentlichkeit zu schaffen ...
Breaking Medicine Technology: