Navigation Links
Balancing oxaliplatin dose with neurological side effects in metastatic colon cancer
Date:2/2/2012

The drug oxaliplatin is a major reason the prognosis for metastatic colon cancer has gone from an expected survival of several months to a couple years. Unfortunately, the drug can also carry with it debilitating neurological side effects, which generally start as the sensation of pins and needles in fingers and toes and can leave patients unable to walk or dress independently.

However, "Many patients don't receive the necessary dose to try to keep their cancer in check, because their symptoms become too debilitating and their quality of life is reduced," says Andrew Weickhardt, MD, clinical fellow at the University of Colorado Cancer Center.

Weickhardt, along with Keith Wells, MD, and Wells Messersmith, MD, CU Cancer Center investigator and developmental therapeutics program co-leader, recently published a review in the Journal of Oncology that describes how to maximize the positives of this tricky balance between oxaliplatin's effects and side effects.

"Before, when patients died in a few months, these symptoms were overlooked. Now they're living two to three years and the symptoms deserve closer attention," Weickhardt says.

The review recommends two approaches, used alone or simultaneously what Weickhardt calls a "stop and go" approach, along with supplements that may mitigate the drug's neurological damage.

In the stop and go approach, a patient starts oxaliplatin along with another drug and takes both for two months. Then, the patient takes a hiatus from oxaliplatin (while continuing the first drug), and reintroduces oxaliplatin two months later or at the point of disease progression, whichever is sooner.

"After about six to nine months of total treatment, metastatic colorectal cancers tend to develop resistance to the drug," says Weickhardt. "And also, no matter what we do, after this same six to nine months of total treatment, neurological side effects start to rise." And so stop-and-go oxaliplatin dosing spreads the drug's effectiveness over the maximum possible time, with the fewest possible side effects.

Still, with this regimen, Weickhardt says that one in twenty patients experience significant nerve damage that can last for more than six months. "There's room for improvement," he says.

Though to date clinical trials of protective drugs given with oxaliplatin have been small, Weickhardt sees promise in the use of simple calcium and magnesium supplements.

"An infusion of calcium and magnesium should be used as well because they've shown some benefit and they don't do any harm," Weickhardt says. "They're popular in the community, and I'd encourage their use."


'/>"/>
Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Brain Balancing Gives Hope for Sufferers of Depression, Stress, and Insomnia at New Life Brain Center
2. Natures Peak Products Along With Company President Paul Wilkinson Were Recently Featured on Segment of Lifetime TV Networks Nationally Broadcast Show The Balancing Act
3. O2 Media's Hit Morning TV Show ‘The Balancing Act' Welcomes Atkins Nutritionals to the Program
4. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes the Arthritis Foundation to the Program
5. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes Resident Chef Jeremy Hanlon to the Program
6. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes Dexter Russell, Inc. to the Program
7. ‘The Balancing Act' and Chicken of the Sea Search for America's ‘Supercook'
8. O2 Media's Hit Morning TV Show ‘The Balancing Act' Welcomes Absolute Miracle Cream to the Program
9. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes HSA Bank to the Program
10. O2 Media's Hit Morning Show ‘The Balancing Act' Welcomes Dr. Bob Arnot to the Program
11. 'The Balancing Act' & Chicken of the Sea Search for America's 'Supercook'
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding them ... a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to provide ... need to turn on a light when taking medication during the night, allowing the ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... Fla. (PRWEB) , ... October 12, 2017 , ... IsoComforter, ... therapy products, announced today the introduction of an innovative new design of the shoulder ... pad so you get maximum comfort while controlling your pain while using cold therapy. ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... SAN DIEGO , Oct. 12, 2017   Divoti ... Medical Alert Jewelry up to the standard of the latest FDA ... (Launched: June 2017). Anyone in need of Medical ID ... Divoti Medical Alert Jewelry are engraved in terms of the ... ...
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
Breaking Medicine Technology: