Navigation Links
Baicalin might be a promising therapeutic tool for severe acute pancreatitis
Date:10/17/2007

Qingyitang, a representative prescription of Traditional Chinese Medicine for SAP was widely used in the orients countries. But its real pharmacological mechanisms of protective effects on SAP have not been investigated still now. Baicalin, the most effective monomer of Baical skullcap root (an essential Traditional Chinese Medicine of Qingyitang), which have been proved a protective effects on renal injury of rats with SAP. The research was recently published on October 14 issue of the World Journal of Gastroenterology because of its great significance for SAP.

It has been confirmed that Baicalin has anti-bacterial, antiviral and anti-inflammatory activities in vitro. It also can inhibit platelet aggregation and eliminate oxygen-free radicals. Animal experiments show that Baicalin could reduce the generation of endotoxin. In addition, Baicalin has potent effect in inhibiting pancreatin which is the initial metabolite of Baicalin. All these pharmacologic actions can inhibit SAP during its multiple stages.

The research team led by Dr. Zhang Xiping from the first people's hospital of Hangzhou and second affiliated hospital of Zhejiang university spent more than five years working with experimental SAP of rats by the intravenous injection of Baicalin treatment. With the large dosage of baicalin treatment, the rats' survival rate, renal function indexes, renal gross changes and lightmicroscopic changes and its severity scores was greatly improved in end. The article clarified that the therapeutic mechanisms might be related to the inhibition of inflammatory mediators and induction of renal cells apoptosis by the application of tissue microarray technique.

Compared with the Octreotide, the most effective drug in the treatment of SAP, the large dosage Baicalin has equally effective as octreotide in terms of reduction of renal pathological alterations of rats with SAP. But for Octreotide, It is difficult to popularize especially in remote areas with poor economy since it features high price, short half-life and inconvenient administration, while Baicalin features low price, extensive routes of administration and preparation, multiple pharmacologic actions and precise therapeutic effects.

So the Baicalin might be a promising therapeutic medicines in the treatment of SAP despite there are still many works to be done future.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. OBESE LIL GIRLS !! SWEAT IT OUT OR U MIGHT BE ASTHAMATIC !!!
2. Anemia Treatment for Cancer Patients Might Not be a Good Idea.
3. Cabbage, cauliflower might contribute to cancer prevention
4. Suicide might be inherited
5. Cleanliness might lead to Asthma
6. Stroke risk might be linked to antibody
7. Change in walking might indicate Dementia
8. Drug might prevent Prostate Cancer Spread
9. Diet might just have an Effect on Breast Cancer
10. Tomatoes Might Inhibit the Development Of Prostate Cancer
11. Mad Cow Disease Might Be Linked to Blood Transfusions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The ... to promote standards of excellence for the field of eating disorders, announces the ... – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... N.Y (PRWEB) , ... October 13, 2017 , ... Lori ... became a member of ElderCounsel, a national organization of elder law and special needs ... changing laws and rules. It also provides a forum to network with elder law ...
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)...  As the latest Obamacare repeal effort moves is ... (R-LA) and Lindsey Graham (R-SC) medical device ... industry is in an odd place.  The industry wants ... tax on medical device sales passed along with the ... increased visits and hospital customers with the funding to ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
(Date:9/13/2017)... 2017   OrthoAtlanta has been named the official ... Committee (AFHC) for the 2018 College Football Playoff (CFP) National ... Mercedes-Benz Stadium in Atlanta, Georgia . OrthoAtlanta ... In" campaign, participating in many activities leading up to, and ... ...
Breaking Medicine Technology: