Navigation Links
Baicalin might be a promising therapeutic tool for severe acute pancreatitis
Date:10/17/2007

Qingyitang, a representative prescription of Traditional Chinese Medicine for SAP was widely used in the orients countries. But its real pharmacological mechanisms of protective effects on SAP have not been investigated still now. Baicalin, the most effective monomer of Baical skullcap root (an essential Traditional Chinese Medicine of Qingyitang), which have been proved a protective effects on renal injury of rats with SAP. The research was recently published on October 14 issue of the World Journal of Gastroenterology because of its great significance for SAP.

It has been confirmed that Baicalin has anti-bacterial, antiviral and anti-inflammatory activities in vitro. It also can inhibit platelet aggregation and eliminate oxygen-free radicals. Animal experiments show that Baicalin could reduce the generation of endotoxin. In addition, Baicalin has potent effect in inhibiting pancreatin which is the initial metabolite of Baicalin. All these pharmacologic actions can inhibit SAP during its multiple stages.

The research team led by Dr. Zhang Xiping from the first people's hospital of Hangzhou and second affiliated hospital of Zhejiang university spent more than five years working with experimental SAP of rats by the intravenous injection of Baicalin treatment. With the large dosage of baicalin treatment, the rats' survival rate, renal function indexes, renal gross changes and lightmicroscopic changes and its severity scores was greatly improved in end. The article clarified that the therapeutic mechanisms might be related to the inhibition of inflammatory mediators and induction of renal cells apoptosis by the application of tissue microarray technique.

Compared with the Octreotide, the most effective drug in the treatment of SAP, the large dosage Baicalin has equally effective as octreotide in terms of reduction of renal pathological alterations of rats with SAP. But for Octreotide, It is difficult to popularize especially in remote areas with poor economy since it features high price, short half-life and inconvenient administration, while Baicalin features low price, extensive routes of administration and preparation, multiple pharmacologic actions and precise therapeutic effects.

So the Baicalin might be a promising therapeutic medicines in the treatment of SAP despite there are still many works to be done future.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. OBESE LIL GIRLS !! SWEAT IT OUT OR U MIGHT BE ASTHAMATIC !!!
2. Anemia Treatment for Cancer Patients Might Not be a Good Idea.
3. Cabbage, cauliflower might contribute to cancer prevention
4. Suicide might be inherited
5. Cleanliness might lead to Asthma
6. Stroke risk might be linked to antibody
7. Change in walking might indicate Dementia
8. Drug might prevent Prostate Cancer Spread
9. Diet might just have an Effect on Breast Cancer
10. Tomatoes Might Inhibit the Development Of Prostate Cancer
11. Mad Cow Disease Might Be Linked to Blood Transfusions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... ... 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited to ... Recovery® program to drive cancer patients to and from their cancer treatments. Comfort ... quality of life and ongoing independence. Getting to and from medical treatments is ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... today at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra ... authored journal articles published in Emergency Medicine Practice and Pediatric Emergency ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
Breaking Medicine Technology: