Navigation Links
Bacterial toxin closes gate on immune response, Penn researchers discover
Date:2/13/2008

ly. And a few years later, Professor Carol Deutsch, among others, demonstrated the presence of potassium channels controlled by voltage in immune cells.

SMase C is made by, among other bacteria, S. aureus, a pathogenic bacterium that causes a range of infections from minor skin lesions to toxic shock. This finding raises the intriguing possibility that the SMase C action against Kv1.3 helps S. aureus to neutralize host defenses, state the authors in the paper.

The findings of this study suggest the possibility that identifying inhibitors of SMase C may be a way to combat S. aureus infections. One strain of S. aureus is the much-talked-about, MRSA, or methycillin-resistant S. aureus. Specific inhibitors of SMase C may expand the choice of therapies for treating MRSA and other resistant S. aureus infections.

This study was conducted in a common experimental system where frog eggs were engineered to have particular voltage-gated ion channels in their membranes. SMases used in the study were purified from bacteria engineered to produce the enzymes.

This new study follows a 2006 study by the same research team showing that an SMase from the brown recluse spider could activate voltage-gated ion channels. In 2007 the team discovered that SMases from lung-infecting bacteria inactivate ion channels that conduct chloride ions, which would in turn aggravate lung infection in some cystic fibrosis patients.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Nerites Receives NIH Grant to Study Novel Treatment for Preventing Dangerous Bacterial Infections on Urinary Stents and Catheters
2. Forsyth launches 1-of-a-kind core service to enable rapid identification of bacterial samples
3. First look at an enzyme target for antibacterial and cancer drugs
4. Breath test can discriminate between a bacterial overgrowth and IBS
5. Antibacterial chemical disrupts hormone activities
6. GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets
7. Early Bacterial Infection May Boost Asthma Risk
8. New viruses to treat bacterial diseases -- My enemies enemy is my friend
9. Antibacterial Soap Claims Just Dont Wash
10. New study suggests link between environmental toxins and early onset puberty in girls
11. Botulinum Toxin Share Higher in Canada Than in the US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... May 23, 2013 If you are ... irritable bowel syndrome (IBS), the food spread this Memorial ... fun. , “While hot dogs and ice cream have ... warm weather months, IBS sufferers often feel the painful ... MD, a gastroenterologist with Lourdes Medical Associates. , IBS ...
(Date:5/23/2013)... UT (PRWEB) May 23, 2013 ... a comprehensive radiology learning environment for all resident ... lessons and assessments, transforms the learning experience from ... curriculum. , “Until RADPrimer 3.0, RADPrimer ... to none,” comments Dr. B.J. Manaster, Professor of ...
(Date:5/23/2013)... a woman harried by hot flashes says she,s having ... online in Menopause , the journal of The ... tests that what these women say about their memory ... that hot flashes were related to memory problems, and ... was a relationship between hot flashes and what women ...
(Date:5/23/2013)... to its destruction inside a cell, a cancer-promoting ... thwart the development of tumor-suppressing microRNAs (miRNAs) before ... publication at Nature . , Under conditions ... epidermal growth factor receptor (EGFR) gums up the ... scientists at The University of Texas MD Anderson ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Transvaginal ... Bard, Inc., continue to move forward in a federal ... of West Virginia, Bernstein Liebhard LLP reports. In ... a request by C.R. Bard to seal emails that ... secrets and other confidential, proprietary information about its suppliers. ...
Breaking Medicine News(10 mins):Health News:Sensitive Stomach? Lourdes Gastroenterologist Advises IBS Sufferers to Think Twice About What They Eat This Holiday Weekend 2Health News:Sensitive Stomach? Lourdes Gastroenterologist Advises IBS Sufferers to Think Twice About What They Eat This Holiday Weekend 3Health News:RADPrimer 3.0 Introduces Comprehensive Radiology Training Curriculum 2Health News:When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs 2Health News:When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs 3Health News:Transvaginal Mesh Lawsuits Move Forward, as Bernstein Liebhard LLP Notes New Order in Federal C.R. Bard Mesh Implant Lawsuits 2Health News:Transvaginal Mesh Lawsuits Move Forward, as Bernstein Liebhard LLP Notes New Order in Federal C.R. Bard Mesh Implant Lawsuits 3
... Oct. 7 (HealthDay News) -- Men develop type 2 diabetes ... finding helps explain why men have higher rates of diabetes ... analyzed data from 51,920 men and 43,137 women in Scotland ... was 31.83 in men and 33.69 in women. This difference ...
... (HealthDay News) -- Women with polycystic ovary syndrome (PCOS), an ... to have parents with some form of heart disease, according ... between PCOS and other family medical conditions, we might be ... an earlier stage," the study,s lead author, Michael Davies, an ...
... Goodwin HealthDay Reporter , FRIDAY, Oct. 7 (HealthDay ... babies, with differences from typically developing infants seen in their ... Researchers said the findings may offer new clues about the ... the children also have a larger brain. Boys ...
... consumers take heed: that high-calorie energy drink or soda ... according to a double-blind, placebo-controlled study that examined responses ... predict how he or she will respond to other ... of other more serious drugs of abuse, such as ...
... Ore. Modern medicine,s ability to save lives through organ ... prevent the human body from rejecting the transplanted organ. ... sometimes serious. A group of researchers led by scientists ... that may be causing many of those side effects. And ...
... Oct. 7 (HealthDay News) -- Nearly your entire brain is ... to a new study. The finding that many more ... to win games, such as rock-paper-scissors, makes sense in terms ... functions to maximize the chance of survival and reproduction, so ...
Cached Medicine News:Health News:Boys With Autism May Grow Faster as Babies 2Health News:Boys With Autism May Grow Faster as Babies 3Health News:Jonesing for java: Could caffeine use predict risk for cocaine abuse? 2Health News:Study uncovers why anti-rejection drugs for transplant patients cause hypertension 2
(Date:5/23/2013)... , May 23, 2013  Hadasit Bio-Holdings Ltd. (TASE: ... biotech companies, based on intellectual property developed and ... ,s foremost medical research center, today announced ... received significant funding from the Israeli Ministry of ... (OCS) to support product development and advance clinical ...
(Date:5/23/2013)... , May 23, 2013  Texas, premier physician ... deliver doctors the survival tools they need to provide ... in today,s health care marketplace. "I am ... save local practices," said Stephen L. Brotherton ... (TMA). " Texas doctors are determined ...
(Date:5/23/2013)... ALBUQUERQUE, N.M. , May 23, 2013  Net ... in the telemedicine market, announced today the company has ... a telemedicine staffing company based in Huntsville, ... agency that specializes in the staffing and recruitment of ... upon completion of the final agreement, which is expected ...
Breaking Medicine Technology:Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 2Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 3
... Ill., Dec. 15, 2010 Hospira, Inc. (NYSE: ... company, today announced that it will host a conference call ... for 2011 on Wednesday, Feb. 2, 2011, at 8 a.m. ... and full-year 2010 results earlier that morning, before the U.S. ...
... Inc., a biotechnology company commercializing the next generation ... Antibody (RabMAb®) technology, today announced that the Company ... operating under contract with the National Cancer Institute ... (NIH) to develop several dozen rabbit monoclonal antibodies ...
Cached Medicine Technology:Epitomics Signs Antibody Development Agreement With the National Cancer Institute 2
...
Malis Curette, bayonet, titanium handle, stainless steel shaft, working distance 102 mm, length 203 mm....
Cobb Curettes, reverse angled, 11"....
Castroviejo "HM" Micro Needle Holder with Tungsten-Carbide Inserts, with catch. Serrated....
Medicine Products: