Navigation Links
Bacterial toxin closes gate on immune response, Penn researchers discover
Date:2/13/2008

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have demonstrated that a bacterial toxin from the common bacterium Staphylococcus aureus shuts down the control mechanism of the tunnel, called an ion channel, in immune cell membranes. Shutting down ion channels has long been known to suppress the immune response, and the bacteria may use the toxin to neutralize host defenses against bacteria. The study is published in the February 14 issue of Nature.

Immune cells, like other cells, have ion channels in their membranes. When the voltage-sensing part of the channel detects an electrical change in the cell membrane, the channel gate opens, allowing small ions such as sodium, potassium, or calcium to flow across the cell membrane. The channels in immune cells called Kv1.3 channels allow only potassium ions to pass, and the activity of these channels is required for triggering an immune response.

We have provided a key piece of evidence for the hypothesis that the negatively charged phosphate groups of membrane lipids around voltage sensors provide the critical electric balance for some of these positive charges in the sensors, says Zhe Lu, MD, PhD, of the Department of Physiology at Penn. The research team, that included Yanping Xu, MD, PhD and Yajamana Ramu, PhD, showed that removal of phosphate head groups from some membrane lipids by the bacterial toxin called sphingomyelinase (SMase) C shuts down the Kv1.3 channel. Therefore if the positive charges are not properly balanced by negative charges, the electrical sensor cannot move to open the gate of the channel. And, if the channel fails to open, the immune response is derailed.

Our study builds on the efforts of two senior colleagues in the Department, says Lu. Twenty-five years ago, Professor Clay Armstrong (now emeritus) hypothesized that the positive charges in the electrical sensor must be balanced by negative charges for the sensor to function proper
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nerites Receives NIH Grant to Study Novel Treatment for Preventing Dangerous Bacterial Infections on Urinary Stents and Catheters
2. Forsyth launches 1-of-a-kind core service to enable rapid identification of bacterial samples
3. First look at an enzyme target for antibacterial and cancer drugs
4. Breath test can discriminate between a bacterial overgrowth and IBS
5. Antibacterial chemical disrupts hormone activities
6. GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets
7. Early Bacterial Infection May Boost Asthma Risk
8. New viruses to treat bacterial diseases -- My enemies enemy is my friend
9. Antibacterial Soap Claims Just Dont Wash
10. New study suggests link between environmental toxins and early onset puberty in girls
11. Botulinum Toxin Share Higher in Canada Than in the US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Shriners Hospitals for Children® and UK ... current location of Shriners Hospitals for Children - Lexington ... the University of Kentucky Albert B. Chandler Hospital. The ... owned and operated by Shriners Hospitals for Children, and ... and their families well into the future. , “The ...
(Date:10/22/2014)... OR (PRWEB) October 22, 2014 During ... California’s fresh water supply runs dangerously low, Southern Oregon’s ... Southern Oregon’s rivers, despite the lowest mountain snow pack ... in late summer and early autumn.* That was the ... of the new book “Hiking Southern Oregon,” during an ...
(Date:10/22/2014)... Although there are only 24 hours in a day, that doesn’t ... finding time within their busy schedules for exercise and fitness. Fortunately, ... to get in shape. Here are five ways you can reach ... Change Up Your Commute , Consider riding a bike or taking ... your daily routine. If you must use your car to get ...
(Date:10/22/2014)... By Steven Reinberg ... -- Infants who quickly add weight and length may be ... study suggests. In adults, certain genes have been linked ... promote proportionate gains in fat and lean muscle, the researchers ... be heavier and taller. By ages 2 and 3, however, ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... A crucial part of conventional in vitro fertilization (IVF) -- ... instead take place in a device inside the vagina, new ... contend that the device, called an INVOcell, might sharply cut ... also make the technology more accessible to those who don,t ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4
... especially common after the death of a spouse , , ... keep up active social lives as they age may ... finds. , Being socially active may increase feelings ... helping maintain memory, researchers say. Social interaction may also ...
... May 29 PartnerRe Ltd.,(NYSE: PRE ) today ... Benchimol is scheduled to present at the Fox,Pitt-Kelton Cochran ... Opportunities for the Insurers... and the Contrast with,Banks." The ... 6, 2008 from 9 a.m. - 2 p.m. local ...
... published a,new report designed to provide critical strategic ... in the market for diagnostics and treatments,in this ... &,Analysis: Alzheimer,s Disease," is based on in-depth interviews ... involved in ongoing,research., "There is some real ...
... New three-year agreement extends alliance members, access to medical product ... ... systems., LOUDON, Tenn., May 29 Adroit ... by Premier,Purchasing Partners, LP. The new agreement centers on Adroit,s leading,Soft-Temp(R) ...
... Help Firms That Already Offer Insurance to Workers, ERIE, ... than 10,000 uninsured adults in Erie County -- many of ... are on a waiting list,to receive health care coverage -- ... them gain access to health insurance., He said small ...
... DR ),is excited to announce the creation ... division and the errors and omissions (E&O),division., ... leadership of senior vice president and national practice,leader, ... combines all,of Darwin,s health care-related professional liability teams ...
Cached Medicine News:Health News:Active Social Life Helps Keep Aging Mind Sharp 2Health News:Active Social Life Helps Keep Aging Mind Sharp 3Health News:PartnerRe Executive Vice President & Chief Financial Officer Albert Benchimol to Present at the FPK CCW Credit Risk Conference in London on June 6, 2008 2Health News:Cardiovascular Meds May Be Beneficial in Alzheimer's Disease, According to MedPredict Report 2Health News:Adroit Medical Systems Awarded Premier Supplier Contract for Temperature Therapy Systems 2Health News:Governor Rendell Says PA ABC Will Help Low-Wage Small Businesses Pay for Employee Health Coverage 2Health News:Governor Rendell Says PA ABC Will Help Low-Wage Small Businesses Pay for Employee Health Coverage 3Health News:Governor Rendell Says PA ABC Will Help Low-Wage Small Businesses Pay for Employee Health Coverage 4Health News:Darwin Announces Creation of New Health Care and Errors and Omissions Divisions 2Health News:Darwin Announces Creation of New Health Care and Errors and Omissions Divisions 3
(Date:10/22/2014)... 2014 Provectus Biopharmaceuticals, Inc. (NYSEMKT: PVCT) specializes ... investigational drug for cancer, is designed for injection into ... Its oncology focus is on melanoma, breast cancer and ... trials of PV-10 as a therapy for metastatic melanoma, ... dermatitis and psoriasis. This summer, the ...
(Date:10/22/2014)... , Oct. 22, 2014  Regulus ... a biopharmaceutical company leading the discovery and ... announced that it has demonstrated human proof-of-concept ... clinical study evaluating RG-101, a wholly-owned, GalNac-conjugated ... of hepatitis C virus infection ("HCV").  Interim ...
(Date:10/20/2014)... California , 20 de octubre de 2014 ... en el campo de la pulmonología intervencional, anunció ... Estudio RENEW, casi 3 meses antes de lo ... de exención de dispositivo de investigación (IDE) aprobada ... para el sistema de espiral de reducción de ...
Breaking Medicine Technology:Provectus Biopharmaceuticals Looks at the Asian Markets: Analyst Coverage by Small Cap Traders 2A Single Subcutaneous Dose of 2mg/kg of RG-101, Regulus' Wholly-Owned, GalNac-Conjugated anti-miR Targeting microRNA-122, Demonstrates 4.1 log10 Mean Viral Load Reduction as Monotherapy at Day 29 in Patients with Varied HCV Genotypes and Treatment H 2A Single Subcutaneous Dose of 2mg/kg of RG-101, Regulus' Wholly-Owned, GalNac-Conjugated anti-miR Targeting microRNA-122, Demonstrates 4.1 log10 Mean Viral Load Reduction as Monotherapy at Day 29 in Patients with Varied HCV Genotypes and Treatment H 3A Single Subcutaneous Dose of 2mg/kg of RG-101, Regulus' Wholly-Owned, GalNac-Conjugated anti-miR Targeting microRNA-122, Demonstrates 4.1 log10 Mean Viral Load Reduction as Monotherapy at Day 29 in Patients with Varied HCV Genotypes and Treatment H 4A Single Subcutaneous Dose of 2mg/kg of RG-101, Regulus' Wholly-Owned, GalNac-Conjugated anti-miR Targeting microRNA-122, Demonstrates 4.1 log10 Mean Viral Load Reduction as Monotherapy at Day 29 in Patients with Varied HCV Genotypes and Treatment H 5A Single Subcutaneous Dose of 2mg/kg of RG-101, Regulus' Wholly-Owned, GalNac-Conjugated anti-miR Targeting microRNA-122, Demonstrates 4.1 log10 Mean Viral Load Reduction as Monotherapy at Day 29 in Patients with Varied HCV Genotypes and Treatment H 6A Single Subcutaneous Dose of 2mg/kg of RG-101, Regulus' Wholly-Owned, GalNac-Conjugated anti-miR Targeting microRNA-122, Demonstrates 4.1 log10 Mean Viral Load Reduction as Monotherapy at Day 29 in Patients with Varied HCV Genotypes and Treatment H 7A Single Subcutaneous Dose of 2mg/kg of RG-101, Regulus' Wholly-Owned, GalNac-Conjugated anti-miR Targeting microRNA-122, Demonstrates 4.1 log10 Mean Viral Load Reduction as Monotherapy at Day 29 in Patients with Varied HCV Genotypes and Treatment H 8PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3
... 2 Data presented today,at the Annual Congress ... investigational oral Factor Xa inhibitor DU-176b reduced the ... patients,undergoing elective unilateral hip replacement surgery. There was ... and the,observed bleeding rates were low across the ...
... Stenting Safe and Effective in Patients ... Has Been Open-Heart Surgery, WASHINGTON, Sept. 1 ... patients with very complex coronary,artery disease can safely choose ... open-heart surgery, says The Society for,Cardiovascular Angiography and Interventions ...
Cached Medicine Technology:Daiichi Sankyo Announces Clinical Study Data for Oral Factor Xa Inhibitor DU-176b 2SCAI: SYNTAX Data Show PCI Is a Good Option for Patients With Complex Coronary Artery Disease 2SCAI: SYNTAX Data Show PCI Is a Good Option for Patients With Complex Coronary Artery Disease 3
... Stealthstation Siremobil Iso-C3D C-Arm imaging system interface ... of mobile C-arm imaging. Combining mobility ... software, the cooperative technologies deliver the most ... 3D imaging is the new standard in ...
... The best of digital mobile imaging ... of,anatomical localization software and instrumentation. Now ... capability to:, Easily Add Visualization ... Dose, Accelerate Intraoperative Decision Making, ...
... the most advanced imaging capabilities into the ... it offers many of the same technologies ... value-oriented platform. Asteion provides the subsecond speed ... scanning, while also supporting everyday, high-resolution scanning ...
... the T.L.I.F. SG Instruments are the ... surgery, offering comprehensive and functionally sound instruments.. ... variety of disc removal and disc preparation ... TLIF procedure. Excellent design, a wide range ...
Medicine Products: