Navigation Links
Bacterial communication encourages chronic, resistant ear infections
Date:7/6/2010

Ear infections caused by more than one species of bacteria could be more persistent and antibiotic-resistant because one pathogen may be communicating with the other, encouraging it to bolster its defenses. Interrupting or removing that communication could be key to curing these infections. Researchers from Wake Forest University Baptist Medical Center publish their findings today in mBio, the online open-access journal of the American Society for Microbiology.

"In this study we show that communication between bacterial species promotes bacterial persistence and resistance to antibiotics, which are important considerations in the diagnosis, preventions and treatment of otitis media (OM)," says W. Edward Swords, an associate professor of microbiology and immunology and senior author of the study. Chelsie Armbruster, a Ph.D. student working in Swords' lab, co-authored the study.

OM is one of the most common childhood infections and is the leading reason for pediatric office visits and new antibiotic prescriptions to children. OM infections often persist for long periods of time and are often resistant to antibiotics. These chronic and recurrent cases of OM involve the persistence of the bacteria within a biofilm community, a state in which they are highly resistant to both natural clearance by the immune system and antibiotic treatment.

Epidemiological data indicate that the majority of chronic OM infections are polymicrobial in nature, meaning they are caused by more than one species of bacteria. Haemophilus influenzae and Moraxella catarrhalis are frequently found together in samples obtained from patients with chronic and recurrent OM.

"Interestingly, a recent study found M. catarrhalis to be more frequently associated with polymicrobial OM infections than from single-species OM infections. This suggests that the presence of other bacterial pathogens may impact the persistence of M. catarrhalis or the severity of disease caused by this species," says Swords.

In examining the dynamics between these two bacteria in culture and animal models, Swords and his colleagues discovered the H. influenzae secreted autoinducer-2 (AI-2), a chemical involved in an interbacterial method of communication known as quorum sensing, that promoted increased biofilm formation and antibiotic resistance in M. catarrhalis.

"We conclude that H. influenzae promotes M. catarrhalis persistence within polymicrobial infection biofilms via inter-species quorum signaling. AI-2 may therefore represent an ideal target for disruption of chronic polymicrobial infections," says Swords. "Moreover, these results strongly imply that successful vaccination against the unencapsulated H. influenzae strains that cause airway infections may also significantly impact chronic M. catarrhalis disease by removing a reservoir for the AI-2 signal that promotes M. catarrhalis persistence within biofilms."


'/>"/>

Contact: Garth Hogan
ghogan@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. FDA to Re-examine Anti-Bacterial Chemical in Soaps, Cleansers
2. Bacterial phylotype alterations in irritable bowel syndrome
3. Lexington Health Care Chooses OnShift for Nurse Scheduling and Employee Communications in all Facilities
4. Mayo Clinic Proceedings: Gabapentin opens window of communication
5. Online Housecalls, Improved Patient Care and Increased Communication Between Doctors and Healthcare Professionals Now Made Possible Through Docgreet.com
6. NTUs Wee Kim Wee School of Communication to host International Communication Association Conference
7. Communication Program Didnt Improve Autism Symptoms
8. iPBX Hosted Communications Service from DSCI Now Includes Bria Softphone
9. Salesforce.com Users Increase Sales and Marketing Communications 320 Percent
10. First Communications, Inc. Announces Audited Results for the Year Ended December 31, 2009
11. Esna Technologies Receives Unified Communications Magazine's 2009 Product of the Year Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... acoustic and privacy panel system. , The Tranquility privacy panel system was ... collaborative office environment. Tranquility panels help reduce noise and provide the visual privacy ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Sam & Associates ... to commercial and residential clients in the California Bay Area, is launching a charity ... in the region. , Heart disease is the primary killer of adult men and ...
(Date:1/19/2017)... ... 19, 2017 , ... For the third year running, Noto ... the surrounding area, is inaugurating a charity event to help raise funds ... Lou Gehrig's disease or motor neurone disease, is a deadly neurological disorder that ...
(Date:1/19/2017)... ... January 19, 2017 , ... Creative messages ... Real Impact contest from Impact Teen Drivers and California Casualty. Entries from students ... , Educational grants totaling $15,000 will be awarded for the best peer-to-peer messages ...
(Date:1/19/2017)... San Diego, CA (PRWEB) , ... January 19, 2017 , ... ... for their 2017 collaboration with the American Heart Association; “Howe” Healthy is Your ... how to stay healthy and active. Each year, Bill Howe Plumbing, Heating & Air ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , January 18, 2017 , , Marks E-QURE ... rd distribution agreement, following similar agreements in ... Wound care is $2 5 ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the ... Tech - Médica Equipos Médicos S.A.S. (TeckMedica) in Colombia ...
(Date:1/19/2017)... Jan. 18, 2017  Magnetic Insight Inc., leader ... into an agreement with inviCRO LLC to develop ... imaging system based on inviCRO,s VivoQuant™ visualization and ... as a complete MPI solution package with the ... or cell imaging in vivo. MPI ...
(Date:1/19/2017)... 2017 The Academy of Managed Care ... (FDA) for its release today of draft guidance ... makers can proactively share clinical and economic information ... emerging therapies awaiting FDA approval. ... AMCP developed during two multi-stakeholder meetings last year ...
Breaking Medicine Technology: