Navigation Links
Bacterial Strain Behind 'Black Death' Plague Is Likely Extinct: Study
Date:8/30/2011

By Alan Mozes
HealthDay Reporter

TUESDAY, Aug. 30 (HealthDay News) -- Using bones retrieved from London's medieval graveyards, scientists have isolated the strain of bacteria thought to be responsible for the Black Death, and determined that it is most likely now extinct.

The plague, caused by a strain of flea-borne bacteria called Yersinia pestis, ravaged Europe close to seven centuries ago. But the variant of the bacterium behind that scourge is different from the modern strain that still causes about 2,000 new cases of bubonic and pneumonic plague each year, researchers said.

The new research also confirms Y. pestis as the culprit behind the medieval outbreak, the study authors said.

"The controversy as to what caused the Black Death is now resolved," said study co-author Hendrik Poinar, associate professor in the department of anthropology at McMaster University in Hamilton, Ontario, Canada. "It clearly was the bacterium Yersinia pestis that was responsible for 30 million deaths some 660 years ago."

Poinar and colleagues from the United States, Germany, and Britain discuss their findings in the Aug. 29 issue of the Proceedings of the National Academy of Sciences.

By it's conclusion, the Black Death outbreak (1347-1351)was responsible for killing off about one-third of Europe's population.

A subsequent 19th century pandemic involving Y. pestis took the lives of roughly 12 million Chinese. And the threat has endured: in the 21st century about 10 to 20 Americans (and more than 2,000 people worldwide) will develop plague each year. Fortunately, experts note that the germ is susceptible to antibiotics so the disease is not as deadly as it once was.

For the new study, the researchers turned to skeletal remains retrieved from the East Smithfield mass burial site in London. The plot is one of only several in the world that archeologists have conclusively linked to the 14th century pandemic.

In all, 109 skeletal remains (derived from Black Death patients buried between 1348 and 1350) underwent comprehensive DNA sequencing. In the end, the team used a new "targeted DNA capture approach" to construct what they say is the "longest contiguous genomic sequence for an ancient pathogen to date."

Comparing the 14th century bacterium against 21st century examples, the investigators reached a definitive conclusion: the two strains are not the same.

What's more, as the medieval bacterium does not match any strains of Y. pestis currently known to be at large, the researchers concluded that the potentially more virulent ancient strain of the bacterium no longer exists.

"Bacteria can mutate over time," explained Dr. Pascal James Imperato, chair of the department of preventive medicine and community health at the State University of New York (SUNY) Downstate Medical Center in New York City. "They have found that the DNA of this ancient bacteria does not exactly match what we have today. Which means we could be dealing with two very different types of organisms.

"This information informs us about transformations that can take place in microorganisms over time," Imperato added. "And that those transformations have a direct bearing on the capability of an organism to cause more or less serious clinical illness, and its ability to be transmitted more efficiently or less efficiently."

Dr. Philip Tierno, director of clinical microbiology and immunology at New York University Langone Medical Center in New York City, agreed.

"Insight into the evolutionary process can be helpful, because you can see what the virulent factors were that actually killed people," he said. "This type of investigation does have value, in that it can potentially highlight what's most lethal about the bacterium now at hand."

Poinar noted that the technology his team used to analyze the centuries-old Y. pestis may help humans fight pathogens today. "This will allow us to assess why they were so virulent in the past, and be better prepared should they re-emerge," he said.

More information

For more on the plague, visit the U.S. National Institute of Allergy and Infectious Diseases.

SOURCES: Hendrik Poinar, Ph.D., associate professor, department of anthropology, McMaster University, Hamilton, Ontario, Canada; Pascal James Imperato, M.D., distinguished service professor and chair, department of preventive medicine and community health, and director, master of public health program, State University of New York Downstate Medical Center, New York City; Philip Tierno, M.D., Ph.D., director, clinical microbiology and immunology, New York University Langone Medical Center, New York City; Aug. 29-Sept. 2, 2011, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. CDC Report Shows Bacterial Meningitis Cases on the Decline
2. Get a whiff of this: Low-cost sensor can diagnose bacterial infections
3. Antibacterial Soap Additive Accumulates in Fish: Study
4. Novel approaches to bacterial caries management: An efficacious solution in view?
5. Use of alcohol-free antibacterial mouth-rinse is associated with decrease in preterm birth
6. Anti-bacterial collar to help mend broken bones
7. Long- and short-sleeved physician workwear receive same amount of bacterial and MRSA contamination
8. New discovery could lead to vaccines for plague and bacterial pneumonias
9. Virus might fight brain tumors better if armed with bacterial enzyme, study shows
10. Bacterial life on and in humans orchestrates health and disease
11. Severe Bacterial Strain Found in Cystic Fibrosis Patients in Canada
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial Strain Behind 'Black Death' Plague Is Likely Extinct: Study
(Date:4/29/2016)... ... April 29, 2016 , ... ... Celiac Association (CCA), is pleased to announce the launch of the GFCP ... articles, recipes, and more. The purpose of the GFCP Scoop site ...
(Date:4/29/2016)... ... April 29, 2016 , ... New York City based oral and maxillofacial surgeon Dr. ... very effective way to treat obstructive sleep apnea. Dr. Jamali is proud to offer this ... procedure that involves one or both jaw bones. This surgery is performed to correct the ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the ... of funding led by Eastside Partners, with participation from existing investor Martin Ventures. ... base and accelerate its technology and product roadmap. , “Jvion is ...
(Date:4/29/2016)... ... April 29, 2016 , ... CURE ... entirely on patients with cancer, today announced that Lynne Malestic, RN, of Eisenhower ... 2016 CURE® Extraordinary Healer® for Oncology Nursing , which honors nurses who have ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... to promote their animal line of probiotics, Petbiotics ™, as they fondly ... turnout of animal rescue groups networking for their non-profit organizations. Animal rescues across ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 28, 2016  While Abbott,s announced purchase of ... valve repair and stent business, healthcare research firm ... more firmly into patient monitoring.  Kalorama said that ... device areas, with double-digit growth expected the next ... Advanced Remote Patient Monitoring . Abbott Laboratories ...
(Date:4/28/2016)... 28, 2016 ... Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter Softwarelösungen ... bekannt, dass neue Führungskräfte zum Team Sicherheit ... die vielfältige Erfahrungen mitbringen.  Dies wird die ...
(Date:4/28/2016)... April 28, 2016 , Net Sales of ... basis over the prior year period, and an increase of ... , Diluted EPS for the first quarter were $0.52 reported, ... $2.00 adjusted, an increase of 29.9% over the prior year ... adjusted earnings guidance for 2016 Zimmer Biomet Holdings, ...
Breaking Medicine Technology: