Navigation Links
Bacteria successful in cancer treatment
Date:9/5/2007

Bacteria that thrive in oxygen starved environments have been used successfully to target cancer tumours, delivering gene therapy based anti-cancer treatments, according to scientists speaking today (Thursday 6 September 2007) at the Society for General Microbiologys 161st Meeting at the University of Edinburgh, UK, which runs from 3-6 September 2007.

For about half of cancer sufferers our traditional treatments such as radiotherapy and chemotherapy are ineffective, so alternative techniques are being developed to target their tumours.

"To target a tumour with gene therapy you need three things. You need to be able to distinguish the tumour from its surrounding healthy tissue. You need to identify a therapeutic gene which will treat the problem. And you need some way of delivering the gene to the tumour", says Dr Jan Theys of Maastricht University, the Netherlands.

"The majority of solid tumours contain regions of low oxygen or dead tissue. This environment encourages the growth of certain bacteria such as the Clostridium family, making them an ideal agent to deliver anti-cancer treatments" says Dr Theys. "We have now shown that genetically engineered clostridia can successfully treat tumours in animals".

Although some notorious clostridia are responsible for causing serious illnesses such as tetanus and botulism, most of them dont cause any diseases in people. They are all anaerobic bacteria, but most can form highly resistant spores which allow them to survive even in oxygen-rich conditions, although they cannot grow or multiply there. But once they meet favourable conditions, such as the dead areas inside tumours, the spores can germinate and the bacteria thrive, making them ideal to target cancers.

The scientists from Maastricht, collaborating with researchers at Nottingham University to speed up progress by sharing technology and knowledge, have proved that using these bacteria to target cancer tumours is effective.

"Our important findings are that if clostridial spores are injected into an animal with cancer they spread throughout the body, but only spores that reach an oxygen starved area of a tumour will germinate, multiply and become active," says Dr Theys. "We know we can genetically engineer clostridia to express essentially any type of therapeutic gene. We have now shown that it is possible to use clostridia to deliver gene therapy safely in experimental animals. And finally, we have demonstrated effective anti-tumour results using these genetically engineered clostridia in animals with tumours".

The research is an important advance in the fight against cancer because clostridia are most effective in the oxygen starved areas of tumours, and it is precisely these areas which are the most difficult to reach with current cancer therapies such as radiotherapy and chemotherapy. The Maastricht scientists believe that a substantial number of patients could benefit from their new treatment strategy.

"For example, only about one third as many lethal DNA disruptions are caused by normal radiotherapy in low oxygen cancer cells as in high oxygen areas. This means that the cancer may not die. By using our gene therapy technique in combination with conventional treatments, we hope to increase the effectiveness of cancer treatments. The next step is to evaluate our technique in a Phase 1 clinical trial of human patients," says Dr Jan Theys of Maastricht University.


'/>"/>
Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Just spice it up!!!!! Anti bacterial effects of spices unraveled in the West
3. Dangerous food bacteria
4. Tongue piercing leads to bacterial infection
5. Honey curbs bacteria in the oral cavity
6. Identifying bacteria made amiable
7. Bacterial discovery may help CF patients
8. Cure for Bacterial Meningitis
9. The Effectiveness Of Antibacterial Products In Reducing Infection
10. Before Weight Loss Surgery One Should Get Tested for Bacteria
11. Light can help fight gum bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... August ... “Vision & Hearing,” advocating for active, healthy lifestyles and highlighting the importance of ... individuals with hearing impairments and shares the latest innovations in hearing aid technology. ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Dawn Johnson Insurance Group, a ... charity drive to generate community support for efforts to educate the local population on ... for all types of cancer. , Each day in America, roughly 4,600 new ...
(Date:8/18/2017)... ... August 18, 2017 , ... Moore Insurance, a ... in east Texas, is launching a regional charity effort to provide publicity assistance ... the Pediatric Brain Tumor Foundation (PBTF) has raised nearly $30 million in donations ...
(Date:8/18/2017)... TX (PRWEB) , ... August 18, 2017 , ... ... management and financial planning firm that serves residential and commercial clients in the ... charity drive to raise community support for the fight against cancer. , Founded ...
(Date:8/18/2017)... ... August 18, 2017 , ... With over 16,000 active ... hormone replacement therapy and integrative medicine, has become a frontrunner for people seeking ... as menopause, andropause, thyroid disorder and adrenal insufficiencies. , Founded in 2003 ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), the ... quarter ended June 30, 2017.  All comparisons, unless otherwise noted, ... Second Quarter 2017 Highlights include: ... $1,089 million, an increase of 3.5% Total ... Gross margin of 7.5% versus 7.6% ...
(Date:8/3/2017)... 2017  Opioid addiction and other drugs of abuse, ... and threatening outcomes, were problems taken on directly as ... that support them, met this week. This according to ... drugs of abuse, procalcitonin and acute kidney injury were ... 69th meeting in San Diego, CA. ...
(Date:8/2/2017)... CaryRx, a next-generation full-service pharmacy, has announced the ... in the Washington D.C. metropolitan area. ... delivery of medications through the convenience of its patient-friendly mobile ... within one hour to any location in D.C. ... invaluable service to Washington D.C. ," says ...
Breaking Medicine Technology: