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Bacteria seek to topple the egg as top flu vaccine tool
Date:12/6/2010

o basic differences in the way that bacteria process proteins compared to more complex eukaryotic cells, which have a nucleus. Proteins are a crucial component of flu vaccine, and keeping the key proteins folded correctly has been a challenge in bacteria, which lack cellular machinery critical to the process.

"It was long accepted as dogma that you could not make a flu vaccine in bacteria that could stimulate a protective immune response in humans," said Treanor. "But in this vaccine, the surface flu protein hemagglutinin was made by E.coli in such a way that it folded correctly, stimulating an authentic immune response. It's almost surprising that this is possible."

VaxInnate addressed the problem by focusing on just one small key protein of hemagglutinin that can be correctly refolded after synthesis in bacteria. The small protein is enough to spur the immune system because it was attached to an adjuvant a compound designed to strengthen the vaccine by stimulating a more robust immune response. Adjuvants currently are not part of U.S. flu vaccines, though they are used in other countries and as parts of other vaccines. Usually, adjuvants are simply mixed into a vaccine, but the latest work offers a new method. A bacterial protein called flagellin was actually fused to a molecule that mimics the flu's hemagglutinin protein a combination designed both to draw the attention of the immune system and immediately amplify it in one step.

The amount of material in the experimental flu shot under study is just a fraction of the amount used in a licensed flu shot. The most successful tests were done with one or two micrograms of vaccine, much smaller than today's licensed 15-microgram shot. About half of participants got a strong immune response at 1 microgram, and about 80 percent got a strong immune response at 2 micrograms.


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Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

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