Navigation Links
Bacteria identified that may lead to inflammatory bowel disease in certain individuals

Certain bacteria that inhabit the intestine provide the environmental trigger that initiates and perpetuates chronic intestinal inflammation in individuals who are genetically susceptible to inflammatory bowel disease (IBD), a study led by Harvard School of Public Health researchers has found.

Inflammatory bowel disease results from a loss of homeostasis, or balance, between the immune system and the microbes that inhabit the intestine. "In this study, we identified two microbes that instigate gut inflammation that leads to inflammatory bowel disease in mice," said lead investigator Wendy Garrett, assistant professor of immunology and infectious diseases at HSPH. "We show using both metagenomic and conventional culture techniques that an individual's genetic background influences what bacteria reside within his or her intestine. Several studies are currently underway examining the intestinal microbial communities of patients with IBD and we are looking forward to exploring the role of the Enterobacteriaceae we have identified in patients with IBD."

The study appears in the September 16, 2010, edition of Cell Host & Microbe.

IBD is a chronic inflammatory disorder that afflicts 1.4 million persons in the US and the incidence is rising around the world. Not only is IBD a devastating and debilitating chronic illness, it is also one of the three highest risk factors for the development of colorectal cancer. There are two principal forms of IBD: Crohn's disease and ulcerative colitis. Approximately 30,000 new IBD cases are diagnosed each year in the U.S.

Whether IBD is caused by individual species of bacteria or disruptions of entire microbial communities remains controversial, said senior author Laurie H. Glimcher, Irene Heinz Given Professor of Immunology at HSPH. "Our findings suggest that answer bridges both hypotheses--specific species of bacteria (Klebsiella pneumoniae and Proteus mirabilis) appear to work in concert with the indigenous gut microbial community to cause IBD."


Contact: Todd Datz
Harvard School of Public Health

Related medicine news :

1. New research technology to target human gut bacteria
2. Outsmarting killer bacteria
3. New research finds evidence of charitable behavior in bacteria
4. Vaccine has cut child cases of bacterial pneumonia, says study
5. Western Diet Populates Kids Stomachs With Bad Bacteria
6. Dawning of a new age in bacteria research
7. Bacterial communication encourages chronic, resistant ear infections
8. Delivery Method May Determine the Bacteria Babies Acquire
9. Stomach Bacteria Might Trigger Rheumatoid Arthritis
10. How bacteria boost the immune system
11. New strain of bacteria discovered that could aid in oil spill, other environmental cleanup
Post Your Comments:
(Date:10/13/2015)... ... , ... The Bill Howe Family of Companies is an award winning HVAC ... remediation services. Family-owned and operated for 35 years, they have maintained value, ethics and ... two years in a row from the Union Tribune Reader’s Poll, a Healthiest Company ...
(Date:10/13/2015)... ... 13, 2015 , ... Doulagivers is O'Brien's licensed training program ... End of Life Doula Training. A Doulagiver is a non-medical person trained to ... Based on her #1 International bestselling book Creating Positive Passings & The Level ...
(Date:10/12/2015)... (PRWEB) , ... October 13, 2015 , ... North American ... (IBC) at the 2015 IBC National Meeting in Rosemont, IL on October 4th. ... dedication, quality, and standards of excellence that customers have come to expect from members ...
(Date:10/12/2015)... ... October 12, 2015 , ... According to an ... female athletes, particularly in the area of track and field, are at a ... than male peers in the same age group. Dr. Steven Meier of Meier ...
(Date:10/12/2015)... ... 12, 2015 , ... The American Society of Clinical Hypnosis ... education and clinical training in a health care discipline. , Many practitioners ... as: losing weight, managing pain, or stopping smoking, etc. Frequently, extravagant statements and ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... Corporation (NASDAQ: LMNX ) today announced that it expects ... 2015 on Monday, November 2, 2015. A press release announcing ... trading. --> --> ... highlights and financial results for the third quarter ended September ... time. . Simply log on to ...
(Date:10/12/2015)...  Millions of smokers worldwide have used vaping to ... An April 2015 study released by a ... cigarettes to be up to 95 percent less harmful ... after the technology was first introduced the potentially harmful ... --> --> Palm Beach Vapors, ...
(Date:10/12/2015)...  In a Sutter Institute of Medical Research study ... and Psychiatry, the blood product intravenous immunoglobulin, or IVIG, ... in patients in the early, pre-dementia phase of Alzheimer,s ... IVIG, extracted from the plasma of more than 1,000 ... protein found in patients with Alzheimer,s disease. Sutter Institute ...
Breaking Medicine Technology: