Navigation Links
Bacteria identified that may lead to inflammatory bowel disease in certain individuals
Date:9/16/2010

Certain bacteria that inhabit the intestine provide the environmental trigger that initiates and perpetuates chronic intestinal inflammation in individuals who are genetically susceptible to inflammatory bowel disease (IBD), a study led by Harvard School of Public Health researchers has found.

Inflammatory bowel disease results from a loss of homeostasis, or balance, between the immune system and the microbes that inhabit the intestine. "In this study, we identified two microbes that instigate gut inflammation that leads to inflammatory bowel disease in mice," said lead investigator Wendy Garrett, assistant professor of immunology and infectious diseases at HSPH. "We show using both metagenomic and conventional culture techniques that an individual's genetic background influences what bacteria reside within his or her intestine. Several studies are currently underway examining the intestinal microbial communities of patients with IBD and we are looking forward to exploring the role of the Enterobacteriaceae we have identified in patients with IBD."

The study appears in the September 16, 2010, edition of Cell Host & Microbe.

IBD is a chronic inflammatory disorder that afflicts 1.4 million persons in the US and the incidence is rising around the world. Not only is IBD a devastating and debilitating chronic illness, it is also one of the three highest risk factors for the development of colorectal cancer. There are two principal forms of IBD: Crohn's disease and ulcerative colitis. Approximately 30,000 new IBD cases are diagnosed each year in the U.S.

Whether IBD is caused by individual species of bacteria or disruptions of entire microbial communities remains controversial, said senior author Laurie H. Glimcher, Irene Heinz Given Professor of Immunology at HSPH. "Our findings suggest that answer bridges both hypotheses--specific species of bacteria (Klebsiella pneumoniae and Proteus mirabilis) appear to work in concert with the indigenous gut microbial community to cause IBD."


'/>"/>

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-998-8819
Harvard School of Public Health
Source:Eurekalert

Related medicine news :

1. New research technology to target human gut bacteria
2. Outsmarting killer bacteria
3. New research finds evidence of charitable behavior in bacteria
4. Vaccine has cut child cases of bacterial pneumonia, says study
5. Western Diet Populates Kids Stomachs With Bad Bacteria
6. Dawning of a new age in bacteria research
7. Bacterial communication encourages chronic, resistant ear infections
8. Delivery Method May Determine the Bacteria Babies Acquire
9. Stomach Bacteria Might Trigger Rheumatoid Arthritis
10. How bacteria boost the immune system
11. New strain of bacteria discovered that could aid in oil spill, other environmental cleanup
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... ... of Patient Experience Journal (PXJ), an international, open access, peer-reviewed journal focused ... half the issue representing international (non-US) based authors, the third volume of PXJ ...
(Date:5/2/2016)... ... 02, 2016 , ... Beanfields, PBC, makers of Beanfields Bean ... students at University of Colorado in Boulder to create new advertising campaigns. , ... the School of Journalism, who selected Beanfields as the brand on which to ...
(Date:5/2/2016)... ... May 02, 2016 , ... Amica Life ... better understand life insurance throughout various life stages. , The site launched on ... needs calculator and content specific to the times when life insurance matters most. ...
(Date:5/2/2016)... ... May 02, 2016 , ... ... for the 2016 Main Residency Match® (“the Match”), the system through which U.S. ... teaching institutions. A record-high 30,750 positions were placed in the 2016 Match, and ...
(Date:5/2/2016)... New York, NY (PRWEB) , ... May 02, 2016 , ... ... Highlighting the year’s best in pet gear and toys, leading product review site ... TTPM Pets Paw of Excellence Awards at their Spring Showcase at the Metropolitan ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... BURLINGAME, Calif. , April 28, 2016 /PRNewswire/ ... first-ever widely accessible breast and ovarian cancer risk ... cancer panel analyzing 30 genes that highly impact ... and women. Available today, the Color Test analyzes ... pancreatic, prostate, stomach, and uterine cancers. The Color ...
(Date:4/28/2016)... 28, 2016 Treato , ... healthcare, announced today that it has been named a ... Vendor in Life Sciences, 2016, Stephen Davies ... report focuses on life-science- oriented analytics, algorithms and smart ... and doctors, confirm medication ingestion, and analyze unstructured information. ...
(Date:4/28/2016)... , April 28, 2016 Oramed Pharmaceuticals ... clinical-stage pharmaceutical company focused on the development of oral drug ... the upcoming PIONEERS 2016 conference, presented by Joseph Gunnar ... in New York . Nadav Kidron ... the conference. Presentation Details:   ...
Breaking Medicine Technology: