Navigation Links
Bacteria identified that may lead to inflammatory bowel disease in certain individuals
Date:9/16/2010

Certain bacteria that inhabit the intestine provide the environmental trigger that initiates and perpetuates chronic intestinal inflammation in individuals who are genetically susceptible to inflammatory bowel disease (IBD), a study led by Harvard School of Public Health researchers has found.

Inflammatory bowel disease results from a loss of homeostasis, or balance, between the immune system and the microbes that inhabit the intestine. "In this study, we identified two microbes that instigate gut inflammation that leads to inflammatory bowel disease in mice," said lead investigator Wendy Garrett, assistant professor of immunology and infectious diseases at HSPH. "We show using both metagenomic and conventional culture techniques that an individual's genetic background influences what bacteria reside within his or her intestine. Several studies are currently underway examining the intestinal microbial communities of patients with IBD and we are looking forward to exploring the role of the Enterobacteriaceae we have identified in patients with IBD."

The study appears in the September 16, 2010, edition of Cell Host & Microbe.

IBD is a chronic inflammatory disorder that afflicts 1.4 million persons in the US and the incidence is rising around the world. Not only is IBD a devastating and debilitating chronic illness, it is also one of the three highest risk factors for the development of colorectal cancer. There are two principal forms of IBD: Crohn's disease and ulcerative colitis. Approximately 30,000 new IBD cases are diagnosed each year in the U.S.

Whether IBD is caused by individual species of bacteria or disruptions of entire microbial communities remains controversial, said senior author Laurie H. Glimcher, Irene Heinz Given Professor of Immunology at HSPH. "Our findings suggest that answer bridges both hypotheses--specific species of bacteria (Klebsiella pneumoniae and Proteus mirabilis) appear to work in concert with the indigenous gut microbial community to cause IBD."


'/>"/>

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-998-8819
Harvard School of Public Health
Source:Eurekalert

Related medicine news :

1. New research technology to target human gut bacteria
2. Outsmarting killer bacteria
3. New research finds evidence of charitable behavior in bacteria
4. Vaccine has cut child cases of bacterial pneumonia, says study
5. Western Diet Populates Kids Stomachs With Bad Bacteria
6. Dawning of a new age in bacteria research
7. Bacterial communication encourages chronic, resistant ear infections
8. Delivery Method May Determine the Bacteria Babies Acquire
9. Stomach Bacteria Might Trigger Rheumatoid Arthritis
10. How bacteria boost the immune system
11. New strain of bacteria discovered that could aid in oil spill, other environmental cleanup
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... The Dermatology ... staff. Dr. Dunbar received his BS in Biology from LSU, graduating summa cum laude. ... School Class President. After his residency in St. Louis, Dr. Dunbar moved to New ...
(Date:7/20/2017)... ... July 20, 2017 , ... There’s a lot of ... and bulging discs are the same thing. But it’s crucial to understand both the ... proper treatment, according to Kaixuan Liu, MD, PhD, founder and president of Atlantic ...
(Date:7/20/2017)... , ... July 20, 2017 , ... ... protection services since 2014, top travel insurance solution company VisitorsCoverage Inc. has launched ... sell all major international travel insurance products online, under their own brand. The ...
(Date:7/20/2017)... ... July 20, 2017 , ... LINET, an international leader in healthcare ... product line: the AVE 2 birthing bed. , Perfectly suitable for labor, delivery, recovery ... of comfort and efficiency to every phase of childbirth. The AVE 2 has many ...
(Date:7/20/2017)... ... July 19, 2017 , ... Dr. Jig Patel is pleased to announce openings ... without a referral. Understanding the difficulties that face people who are missing teeth ... permanent alternative to removable dentures and bridges. Not only does an implant improve oral ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... Inc. (NYSE: HRC), will host its fiscal third quarter 2017 ... beginning at 7:30 a.m. (CDT) / 8:30 a.m. (EDT). ... the conference call, dial (877) 304-8969 (domestic) or (631) 291-4543 ... prior to the start to allow time to connect. The ... Webcast: A simultaneous webcast of the call will be ...
(Date:6/16/2017)... Datascope Corp. is voluntarily performing a worldwide field correction of certain Intra-Aortic Balloon ... ... CS100i ... 0998-UC-0446HXX; 0998-UC-0479HXX 0998-00-3013-XX;  0998-UC-3013-XX 0998-00-3023-XX;  ... This field correction also applies to any System 98 ...
(Date:6/14/2017)... Va. , June 14, 2017  ivWatch LLC, ... and effectiveness of intravenous (IV) therapy, is pleased to ... the category of Nonsurgical Hospital Supplies and Equipment at ... awards program for the medtech industry. The award was ... the Jacob K. Javits Center in New ...
Breaking Medicine Technology: