Navigation Links
Bacteria identified that may lead to inflammatory bowel disease in certain individuals

Certain bacteria that inhabit the intestine provide the environmental trigger that initiates and perpetuates chronic intestinal inflammation in individuals who are genetically susceptible to inflammatory bowel disease (IBD), a study led by Harvard School of Public Health researchers has found.

Inflammatory bowel disease results from a loss of homeostasis, or balance, between the immune system and the microbes that inhabit the intestine. "In this study, we identified two microbes that instigate gut inflammation that leads to inflammatory bowel disease in mice," said lead investigator Wendy Garrett, assistant professor of immunology and infectious diseases at HSPH. "We show using both metagenomic and conventional culture techniques that an individual's genetic background influences what bacteria reside within his or her intestine. Several studies are currently underway examining the intestinal microbial communities of patients with IBD and we are looking forward to exploring the role of the Enterobacteriaceae we have identified in patients with IBD."

The study appears in the September 16, 2010, edition of Cell Host & Microbe.

IBD is a chronic inflammatory disorder that afflicts 1.4 million persons in the US and the incidence is rising around the world. Not only is IBD a devastating and debilitating chronic illness, it is also one of the three highest risk factors for the development of colorectal cancer. There are two principal forms of IBD: Crohn's disease and ulcerative colitis. Approximately 30,000 new IBD cases are diagnosed each year in the U.S.

Whether IBD is caused by individual species of bacteria or disruptions of entire microbial communities remains controversial, said senior author Laurie H. Glimcher, Irene Heinz Given Professor of Immunology at HSPH. "Our findings suggest that answer bridges both hypotheses--specific species of bacteria (Klebsiella pneumoniae and Proteus mirabilis) appear to work in concert with the indigenous gut microbial community to cause IBD."


Contact: Todd Datz
Harvard School of Public Health

Related medicine news :

1. New research technology to target human gut bacteria
2. Outsmarting killer bacteria
3. New research finds evidence of charitable behavior in bacteria
4. Vaccine has cut child cases of bacterial pneumonia, says study
5. Western Diet Populates Kids Stomachs With Bad Bacteria
6. Dawning of a new age in bacteria research
7. Bacterial communication encourages chronic, resistant ear infections
8. Delivery Method May Determine the Bacteria Babies Acquire
9. Stomach Bacteria Might Trigger Rheumatoid Arthritis
10. How bacteria boost the immune system
11. New strain of bacteria discovered that could aid in oil spill, other environmental cleanup
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/27/2016)... ... , ... recently awarded their highest five-star rating to Best Buy Eyeglasses, ... the United States and Canada wear eyeglasses. Once considered to be a purely functional ... a fashion statement. Even celebrities use glasses as a way of creating an iconic ...
(Date:6/26/2016)... Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in ... in honor of the city’s history as home to some of the world’s leading ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: