Navigation Links
Bacteria eyed for possible role in atherosclerosis
Date:1/5/2011

possible gate to the circulation.

Bacteria can gain access to the circulation through different avenues, and then penetrate the vascular walls where they can create secondary infections that have been shown to lead to atherosclerotic plaque formation, the researchers continued. "In order to test the idea that bacteria are involved in vascular pathogenesis, we must be able not only to detect bacterial DNA, but first of all to isolate the bacterial strains from the vascular wall from the patient," Dr. Kozarov said.

One specific avenue of infection the researchers studied involved bacteria getting access to the circulatory system via internalization in white blood cells (phagocytes) designed to ingest harmful foreign particles. The model that Dr. Kozarov's team was able to demonstrate showed an intermediate step where Enterobacter hormaechei is internalized by the phagocytic cells, but a step wherein bacteria are able to avoid immediate death in phagocytes. Once in circulation, Dr. Kozarov said, bacteria using this "Trojan horse" approach can persist in the organism for extended periods of time while traveling to and colonizing distant sites. This can lead to multitude of problems for the patients and for the clinicians: failure of antibiotic treatment, vascular tissue colonization and initiation of an inflammatory process, or atherosclerosis, which ultimately can lead to heart attack or stroke.

"Our findings warrant further studies of bacterial infections as a contributing factor to cardiovascular disease, and of the concept that 'bacterial persistence' in phagocytic cells likely contributes to systemic dissemination," said Dr. Kozarov, an associate professor of oral biology at the College of Dental Medicine. Dr. Jingyue Ju, co-author and director of the Columbia Center for Genome Technology & Bio-molecular Engineering, also contributed to this research, which was supported in part by a grant from the National Heart, Lung, and Blood I
'/>"/>

Contact: Alex Lyda
alyda@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. AGA, General Mills announce grant to uncover role between intestinal bacteria and health and disease
2. Bacterial life on and in humans orchestrates health and disease
3. Bacteria seek to topple the egg as top flu vaccine tool
4. Learning the language of bacteria
5. Toxins from Staph Bacteria Disrupt Immune System
6. Latest American Chemical Society podcast: New water filter kills disease-causing bacteria
7. Severe Bacterial Strain Found in Cystic Fibrosis Patients in Canada
8. Unexpectedly small effects of mutations in bacteria bring new perspectives
9. Common stomach bacteria may fight off inflammatory bowel disease caused by Salmonella
10. Knowledge gaps, fears common among parents of children with drug-resistant bacteria
11. Intestinal enzyme helps maintain population of beneficial bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 17, 2014 U.S. News and ... the country, and three mesothelioma treatment centers made ... the mesothelioma law firm Baron and Budd ... University of Texas MD Anderson Cancer Center and ... publication. ( http://health.usnews.com/best-hospitals/rankings/cancer ) , U.S. News and ...
(Date:9/17/2014)... DMG Productions announces the upcoming ... to broadcast on Wednesday, September 24, 2014 at ... this episode, Innovations will go behind the scenes ... provide each client the opportunity to achieve the ... the principles of Care, Compassion, and Commitment. , ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Experienced dress ... making a new selection of trendy black bridesmaid dresses. ... for all its beautiful bridesmaid outfits. Readers can ... , Discount-Dress.com is a famous brand ... of new additions as well as revamped old editions, ...
(Date:9/17/2014)... Headquartered in Baltimore, Maryland, Therapy ... the country. , “The past two weeks have ... grown to over 400 evaluators in 46 states, and ... the Midwest and South Dakota and Vermont. And from ... our volunteers can visit.” , TPU provides one-of-a-kind treatment ...
(Date:9/17/2014)... Request A Test , a leading national provider of ... drug testing through the end of September 2014. ... by employers for workplace or new hire screenings. Employers ... promo code DRUG10 when placing an order. Statistics have ... especially for marijuana or THC. Request A Test offers ...
Breaking Medicine News(10 mins):Health News:Three Mesothelioma Treatment Centers Make U.S. News and World Report’s List of Top Cancer Care Facilities, Baron and Budd Reports 2Health News:Three Mesothelioma Treatment Centers Make U.S. News and World Report’s List of Top Cancer Care Facilities, Baron and Budd Reports 3Health News:Innovations to Explore Substance Abuse and Mental Health in Upcoming Episode Airing Wednesday, September 24, 2014 via Discovery Channel. 2Health News:Discount-Dress.com’s Top Designers Are Now Busy Making Its New Black Bridesmaid Dresses 2Health News:Therapy Pets Unlimited is Expanding 2Health News:Therapy Pets Unlimited is Expanding 3Health News:Request A Test Can Save You 10% on Drug Testing 2Health News:Request A Test Can Save You 10% on Drug Testing 3
... Heart patients and cardiologists across the country are ... access be preserved as discussions about healthcare ... for Medicare and Medicaid Services (CMS) - scheduled to ... the accessibility of life-saving cardiology testing and services currently ...
... Health System study has found that high-risk surgery ... were seen by general internists trained in managing ... underwent high-risk orthopaedic surgeries experienced shorter stays when ... surgeons. And, the study found, patients reported they ...
... true for current H1N1 strain remains a mystery, , THURSDAY, ... 1918 Spanish flu pandemic while still in their mother,s womb ... 60 years later, a new study has found. , The ... people worldwide, including 500,000 in the United States. That flu, ...
... Effort Illustrates Broad Public Support for Addressing Crisis ... Oct. 1 Citizens of Delaware ... and wellness with the launch today of "Say ,Yes, to ... video campaign of the Partnership to Fight Chronic Disease (PFCD) ...
... Pink Sheets Filings Reply To Shareholders ... General Corporate Update, , SHENZHEN, China, Oct. 1 /PRNewswire-FirstCall/ ... based operating subsidiary Mellow Hope and Serbia operating Subsidiary ... attention to today,s Pink Sheets filing. The filing found ...
... Whether they can have children is one of the ... cancer because fertility can be compromised by cancer treatment. ... studies led by researchers at Fred Hutchinson Cancer Research ... will adversely impact their newborns. The studies, presented as ...
Cached Medicine News:Health News:Proposed Medicare Changes Will Increase Costs to Government, Decrease Options for Patients 2Health News:Proposed Medicare Changes Will Increase Costs to Government, Decrease Options for Patients 3Health News:How to reduce hospital stays and increase patient satisfaction 2Health News:Pre-Birth Exposure to 1918 Flu Raised Heart Risks, Study Finds 2Health News:Pre-Birth Exposure to 1918 Flu Raised Heart Risks, Study Finds 3Health News:Delaware Residents Participate in Launch of National Video Campaign: 'Say 'Yes' to Health Reform' 2Health News:Delaware Residents Participate in Launch of National Video Campaign: 'Say 'Yes' to Health Reform' 3Health News:Hard to Treat Diseases (HTDS) Management Discussion 2Health News:Hard to Treat Diseases (HTDS) Management Discussion 3Health News:Studies find few risks to newborn offspring of parents who are childhood cancer survivors 2
(Date:9/16/2014)... 2014 A study led by St. ... chemotherapy dose threshold below which male childhood cancer survivors ... appears in September 17 edition of the journal ... are at highest risk for reduced sperm production as ... of pre-treatment fertility preservation methods such as sperm banking. ...
(Date:9/16/2014)... CHICAGO , Sept. 16, 2014 The ... submitted survey data from more than 1,100 patients and ... Food and Drug Administration (FDA) for the Patient-Focused Drug ... This is a new FDA initiative to seek patient ... expectations for therapeutic treatments. "We applaud the ...
(Date:9/16/2014)... 2014 Astellas announced today it has ... & Advocacy, Urology in the Americas. Noland will report ... Margaret Long. In this role, Noland will be responsible ... and advocacy organizations, as well as collaborating with ... Noland,s appointment is the latest phase in the ...
Breaking Medicine Technology:Improved risk identification will aid fertility preservation in young male cancer patients 2Improved risk identification will aid fertility preservation in young male cancer patients 3Improved risk identification will aid fertility preservation in young male cancer patients 4PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 2PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 3PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 4Christy Noland to Lead Urology Advocacy and Communications for Astellas 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: