Navigation Links
BWH researchers discover new vaccine candidate for Pseudomonas aeruginosa
Date:7/6/2012

BOSTON, MAResearchers at Brigham and Women's Hospital (BWH) have discovered a new vaccine candidate for the bacterium Pseudomonas aeruginosa taking advantage of a new mechanism of immunity.

The study was published online in the American Journal of Respiratory and Critical Care Medicine on June 21, 2012.

Pseudomonas aeruginosa is a leading cause of hospital-acquired infections, particularly in patients on respirators, where it can cause so-called ventilator-associated pneumonia, which carries a very high mortality rate. Pseudomonas also causes lung infections in people with cystic fibrosis, a genetic disorder that renders the lungs susceptible to bacterial infection.

Despite more than 40 years of vaccine research and development, there is no clinically available vaccine for this bacterium. Most prior vaccine efforts have focused on generating antibodies to Pseudomonas toxins or surface molecules, especially the sugar coating on the bug called the lipopolysaccharide O antigen. These approaches have not yielded a licensed vaccine for humans.

Gregory Priebe, MD, BWH Division of Infectious Diseases, Department of Medicine, and Boston Children's Hospital Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, along with researchers from Harvard Medical School, constructed a vaccine based on a new mechanism of immunity to Pseudomonas mediated by T helper 17 (Th17) cells. Th17 cells are a recently described type of helper T cells that secrete the cytokine IL-17 and enhance antibacterial mucosal defenses.

In the current studies, the investigators designed a screen for Th17-stimulating protein antigens expressed by a molecular library of DNA encoding Pseudomonas proteins. The screen discovered that the Pseudomonas protein PopB is a very effective stimulator of Th17 immunity, and immunization with purified PopB protected mice from lethal pneumonia in an antibody-independent fashion.

The researchers are currently taking their work a step further by constructing conjugate vaccines using PopB as a protein carrier with the hopes of improving the effectiveness of the vaccine. They hope that the PopB-based vaccine might one day be used to prevent Pseudomonas infections in hospitalized patients and in people with cystic fibrosis.


'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... 2017 , ... Permobil has just completed the acquisition of ... systems has a well-earned reputation for premium quality, with a focus on fit ... in the custom seating business, which enjoys strong demand, and it complements Permobil’s ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... announce their recent partnership with an innovator in the wheelchair accessibility industry, ... motivate their dealer salespeople to sell wheelchair accessible vehicles. With this new incentive ...
(Date:1/16/2017)... ... January 16, 2017 , ... Date aired: January 9, 2017 ... Sharon Kleyne, America’s leading water educator, researcher and advocate welcomed health activist, author, ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health on ...
(Date:1/16/2017)... ... January 16, 2017 , ... In ... education and high-level training standards to an international multidisciplinary group of healthcare treatment ... As a way to further its mission at the grassroots level, iaedp launched ...
(Date:1/16/2017)... ... 16, 2017 , ... San Francisco dentist, Dr. Ben Amini , the ... device which is capable of taking digital impressions of teeth and gums. Conventional bite ... CAD CAM restorations , in terms of speed, efficiency and patient comfort. Increasingly, digital ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... --  The Harrington Discovery Institute at University ... has announced the 2017 recipients of Harrington Scholar-Innovator ... whose research shows promise to advance the standard ... – part of The Harrington Project for Discovery ... medicine: to advance early breakthroughs into the clinical ...
(Date:1/16/2017)... , January 16, 2017 According to the ... Controller, Multi Display , Smart Display, Graphic LCD Controller), Application (Industrial ... 2022", published by MarketsandMakets, the market is expected to grow from USD ... a CAGR of 9.68% between 2016 and 2022. ... ...
(Date:1/16/2017)... 16, 2017 The ... Type (Methyl, Ethyl, Hydroxyethyl, Hydroxypropyl, Carboxymethyl Cellulose), ... Surface Coatings & Paints), Region - Global ... market was valued at USD 4.51 Billion ... USD 6.41 Billion by 2021, at a ...
Breaking Medicine Technology: