Navigation Links
BUSM researchers show an oncolytic virus switches off cancer cell survival signal
Date:12/1/2010

(Boston) Researchers from Boston University School of Medicine (BUSM) have identified a mechanism by which specific viruses acting as oncolytic agents can enter and kill cancer cells. This finding, which is currently featured in an online edition of the Journal of Virology, could help lead to the development of more targeted treatments against many types of cancer.

The study was conducted by Ewan F. Dunn, a postdoctoral fellow, under the direction of John H. Connor, an assistant professor of microbiology at BUSM.

The virus, known as vesicular stomatitis virus (VSV), is being developed in the Connor lab and in other international research laboratories to kill cancer cells. VSV is not a significant human pathogen.

VSV is sensitive to the innate immune response, which causes lymphocytes to release interferon and protect the body from developing an infection. Cancer cells lose the ability to respond in that way, said Dunn. "When cancer cells transform, they become non-responsive, leaving them vulnerable to viruses attacking the cell and its function."

Previous research has shown that a major signaling pathway in cancer cells, called the AKT signaling pathway, is frequently turned on. AKT signaling is a cell survival signal, helping to keep the cancer cells alive. The team demonstrated was that VSV can switch off that signaling pathway, which suggests that a single viral protein could play a major role in cancer cell death.

"This study showed the important role of VSV in killing cancer cells through turning off a major survival signal," added Connor. "The identification of this mechanism is fundamental to understanding how VSV and other oncolytic viruses function."


'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers use patients own blood to treat hamstring injury
2. Sporadic breast cancers start with ineffective DNA repair systems, Pitt researchers find
3. Researchers identify a molecular switch that controls neuronal migration in the developing brain
4. UCLA researchers discover drug resistance mechanisms in most common form of melanoma
5. Researchers shine light on how some melanoma tumors evade drug treatment
6. New function of gene in promoting cancer found by VCU researchers
7. Stanford researchers first to turn normal cells into 3-D cancers in tissue culture dishes
8. Researchers find new target for stopping tumors developing their own blood supply
9. Researchers identify PTSD measures for use in traumatic brain injury research
10. New insight into the cause of common dementia found by researchers at Mayo Clinic
11. Researchers fight Americas other drug problem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet’s ... ostomy patients, standing as living proof that attitude and determination can combine into ... issues that spike around the holidays. This campaign will offer patients a new-found ...
(Date:12/2/2016)... Honolulu, Hawaii (PRWEB) , ... December 02, 2016 ... ... 3, 2016 at the Hyatt Regency Waikiki Beach Resort and Spa in Honolulu, ... (CME) in the field of pain management. , The demand for supplemental ...
(Date:12/2/2016)... Aliso Viejo, California (PRWEB) , ... December 02, 2016 , ... ... that will allow FCPX editors to create versatile lower third titles with just a ... , Pro3rd Accents Volume 2 includes 30 lower third animations. Choose from various ...
(Date:12/2/2016)... ... ... ‘Tis the season for giving! Today, 20 creative teams across the nation found ... Drug Enforcement Administration as part of the National Red Ribbon Week Photo Contest. The ... their campuses with this year’s Red Ribbon Week theme: “YOLO. Be Drug Free,” earn ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center ... has announced the opening of a new eating disorder treatment center location in ... treatment for adults and adolescents, both males and females ages 10 and older ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , December 2, 2016 On ... down 1.36%; the Dow Jones Industrial Average edged 0.36% higher, ... 2,191.08, down 0.35%. Losses were broad based as six out ... has initiated research reports on the following Services equities: Myriad ... QGEN ), INC Research Holdings Inc. (NASDAQ: ...
(Date:12/2/2016)... , Dec. 1, 2016 Around the ... country, region and each habitable land present over earth. ... every individual once in a life time this is ... care available until now. Given the steady increase in ... together with the spiraling healthcare costs of treatment, there ...
(Date:12/2/2016)... NEW YORK , December 2, 2016 ... some of its past losses following Trump,s victory early ... growth potential, and fund managers are now predicting an ... look at four equities to see how they have ... CLDX ), Amicus Therapeutics Inc. (NASDAQ: ...
Breaking Medicine Technology: