Navigation Links
BUSM researchers involved in first international collaboration on genetics of Alzheimer's disease
Date:2/1/2011

Feb. 1, 2011, Boston - The launch of the International Genomics of Alzheimer's Project (IGAP) a collaboration formed to discover and map the genes that contribute to Alzheimer's disease was announced today by a multi-national group of researchers including Drs. Lindsay Farrer and Sudha Seshadri at Boston University School of Medicine (BUSM). The collaborative effort, spanning universities from both sides of the Atlantic, will combine the knowledge, staff and resources of four consortia that work on Alzheimer's disease genetics.

The four groups are:

  • The European Alzheimer's Disease Initiative (EADI) in France led by Philippe Amouyel, M.D., Ph.D., at the Institute Pasteur de Lille and Lille University.
  • The Alzheimer's Disease Genetics Consortium (ADGC) from the United States led by Gerard Schellenberg, Ph.D., at the University of Pennsylvania School of Medicine.
  • The Genetic and Environmental Risk in Alzheimer's Disease (GERAD) from the United Kingdom led by Julie Williams, Ph.D., at Cardiff University.
  • The neurology subgroup of the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) led by Sudha Seshadri, M.D., at BUSM.

One of the research teams at BUSM, directed by Lindsay Farrer, PhD, a professor and chief of biomedical genetics at BUSM, is co-leading the primary analyses for IGAP on behalf of the Alzheimer's Disease Genetic Consortium (ADGC), which includes investigators from 44 different universities and research institutions across North America. The researchers will analyze detailed clinical information and genetic profiles obtained from more than 40,000 Alzheimer cases and cognitively normal persons. Other researchers from Boston University involved in this effort are Drs. Gyungah Jun and Kathryn Lunetta.

"Identification of genes that contribute to Alzheimer's risk and that influence the progression of disease will help lead us to the cause of the disease, identify proteins and other new targets for drug development, and provide genetic methods for determining which people are at greatest risk for Alzheimer's disease when preventative measures become available," said Dr. Schellenberg.

"This is extremely important work in taking our ability to detect and treat Alzheimer's disease to the next level," said Dr. Amouyel.

"As cohort researchers, we are particularly interested in understanding the relationship between genes we uncover through the IGAP consortium and environmental risk factors," said Dr. Seshadri, an associate professor of neurology at BUSM and senior investigator heading the neurogenetics core at the Framingham Heart Study. Other researchers involved with CHARGE include: Drs. Monique Breteler, Cornelia van Duijn and M. Arfan Ikram of the Rotterdam Study; Drs. Oscar Lopez, Annette Fitzpatrick, Josh Bis and Bruce Psaty of the Cardiovascular Health Study; Drs. Lenore Launer and Vilmundur Gudnason of the AGES-Reykjavik study; and Drs. Anita DeStefano, Phillip Wolf and Stephanie Debette from Boston University and the Framingham Heart Study.

While each consortium alone is currently working with thousands of participants including people with Alzheimer's and those free of dementia scientists in the four groups recognize that only by working together can they amass a large enough collection of participants to accelerate gene discovery. Formation of IGAP creates a shared resource database that includes genetic data for the more than 40,000 individuals.

"While each of the consortia have made important contributions, the collective research and intellectual resources of IGAP will certainly uncover many more Alzheimer susceptibility genes and, thus, a much better understanding of the pathways leading to the disease," said Dr. Farrer.

Drs. Amouyel, Schellenberg, Seshadri and Williams are enthused about the collaboration that brings together, for the first time, all of the large genetics groups in the world working on Alzheimer's disease. They share high expectations that the cooperative effort will greatly advance knowledge about Alzheimer's disease.

"Working together on this scale will bring us years closer to understanding this cruel disease, and to the development of new Alzheimer's treatments," said Dr. Williams.

The formation of IGAP is supported by the Alzheimer's Association (www.alz.org) and the Fondation Plan Alzheimer (www.fondation-alzheimer.org).

"We're pleased to fund this project that will bring together well-established and highly regarded research groups throughout the world to enable an unprecedented sharing and analysis of Alzheimer genetic data," said William Thies, Ph.D., Alzheimer's Association Chief Medical and Scientific Officer, and Philippe Lagayette, President of the Fondation Plan Alzheimer in France.

Alzheimer's disease is a progressive, neurodegenerative disorder that is fatal, and has no prevention methods and no cure. Available drugs only marginally affect disease symptoms, making Alzheimer's disease effectively untreatable. Alzheimer's disease invariably progresses to complete incapacitation and death over a period of several years.

In the World Alzheimer Report 2010, Alzheimer's Disease International estimates that there are now 35.6 million people living with dementia worldwide, increasing to 65.7 million by 2030 and 115.4 million by 2050. According to the Report, the total estimated worldwide costs of dementia are US $604 billion in 2010.

"The skyrocketing prevalence and cost of Alzheimer's disease and related dementias will soon undermine the delivery of healthcare worldwide," said Dr. Schellenberg. "That gives innovative collaborations like this new international genomics project added incentive to act quickly and boldly to make new discoveries."

"Our first efforts will be to bring together all the data from the different groups so that they can be analyzed," said Dr. Amouyel. "The next step will be to perform new analysis on subjects not yet in any genetics studies to further increase the number of people in our studies and to increase the ability to detect new genes."


'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Trained Labrador Can Sniff Out Colon Cancer, Researchers Say
2. Researchers discover signaling pathway crucial to acute lung injury
3. Researchers discover root cause of blood vessel damage in diabetes
4. Researchers discover age of onset of puberty predicts adult osteoporosis risk
5. Ben-Gurion U. researchers determine that a first medical opinion can influence the second
6. Researchers uncover link to increased atherosclerosis risk in lupus patients
7. Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
8. RIC study suggests researchers are entering a new era of advances in brain research
9. Zebrafish popular with researchers
10. UCLA researchers eliminate major roadblock in regenerative medicine
11. Researchers use cell profiling to detect abnormalities -- including cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
Breaking Medicine Technology: