Navigation Links
BUSM researchers find link between pulmonary inflammation, diesel exhaust, house dust
Date:12/14/2011

(Boston) A study conducted by researchers at Boston University School of Medicine (BUSM) has found that diesel exhaust particulates (DEP) and house dust extract (HDE) causes pulmonary inflammation that aggravates asthma. The study led by principle investigator Jiyoun Kim, PhD, professor of pathology, was published in the December issue of The American Journal of Pathology and was selected by the editorial board as the only article for an in-depth discussion in the journal's commentary section.

Numerous exposures such as viral infections, indoor as well as outdoor allergens and ambient pollution contribute to the development of asthma in childhood and the persistence of asthma in adulthood. Environmental influences weigh heavily on early lung growth, particularly traffic-related pollution. Children develop asthma and related pulmonary infections at an increased rate when exposed to these pollutants.

Exposure to both HDE and DEP demonstrated increased mucus production and higher airway resistance compared to exposure to only HDE. Pulmonary inflammation was measured by oxidative stress, respiratory physiological features, inflammatory cell recruitment and local CXC chemokine production, or soluble mediators of inflammation.

"The highlight of our study is that you can remove some of the allergen exposure by cleaning, but DEP's are especially hard to avoid in urban environments," explained Kim.

According to Kim, this research also shows a direct link between air pollution and exacerbation of pre-existing pulmonary diseases, like asthma. "We haven't reached a medicinal solution yet, but this study reveals that there could be a tangible therapeutic target and that anti-oxidative treatment could be beneficial to asthmatic patients, especially those with increased exposure to air pollutants."


'/>"/>

Contact: Gina Orlando
gina.orlando@bmc.org
617-638-8490
Boston University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... be a new salve to dominate medicine cabinets of the ... Salamanders may not be the cuddliest of animals, but they ... damaged body parts. Now, a new report published in the ... , identifies a small protein (called a "peptide") from the ... the secret of this amazing wound healing trick in humans. ...
(Date:9/2/2014)... Society of Nuclear Medicine and Molecular Imaging (SNMMI) is ... Wagner-Torizuka Fellowship. This two-year fellowship, founded in 2008 by ... late Kanji Torizuka, MD, PhD, is designed to provide ... medicine and molecular imaging for Japanese physicians in the ... is proud to sponsor the Wagner-Torizuka Fellowship. This program ...
(Date:9/2/2014)... new guideline, the Society for Maternal-Fetal Medicine has recommended ... , "There is no evidence that bed rest ... Center for Maternal and Fetal Medicine and one of ... that bed rest can be harmful for moms, babies, ... are placed on bed rest during their pregnancy. Surveys ...
(Date:9/2/2014)... Vertebral invasive compression fractures called spine ... in our spine suffers crack or gets deformed. Vertebral ... people with osteoporosis or low bone density. Though osteoporosis ... of metastatic tumors and extensive trauma such as an ... also lead to such fractures. , The placement of ...
(Date:9/2/2014)... Sept. 2, 2014 Cancer screening is a critical ... are often more treatable. But while there are already ... there is a great need for even more safe, ... , Now a team of researchers led by Shaoxin ... the potential of a new, non-invasive method to screen ...
Breaking Medicine News(10 mins):Health News:Salamander skin peptide promotes quick and effective wound healing in mice 2Health News:SNMMI 2014-2016 Wagner-Torizuka Fellowship recipients announced 2Health News:SMFM releases paper on activity restriction in pregnancy 2Health News:An Overview of the Minimally Invasive Vertebral Compression Fracture Repair Market by Transparency Market Research 2Health News:An Overview of the Minimally Invasive Vertebral Compression Fracture Repair Market by Transparency Market Research 3Health News:New method for non-invasive prostate cancer screening 2
... Investigacin Oncolgica (GENYO) of which the University of Granada, ... identified the genetic and phenotypic changes that cause tumor ... the main cause of cancer death- is caused by ... relationship with the organ originally affected. For this to ...
... the University of Michigan Health System shows the risk ... following the implementation of Model of End Stage Liver ... how liver transplant allocation is decided. The study, ... in the Department of Internal Medicine, examined the effect ...
... developing disorders like addiction and depression, according to a ... Proceedings of the National Academy of Sciences . ... coauthor of the paper and a professor of neuroscience ... Sciences. She and coauthor David Sturman, a MD/PhD student ...
... Calif. Researchers at the Stanford University School of Medicine ... effectively predict how deadly a cancer will be. The discovery, ... faster, less expensive and more accurate analysis of cancer risk ... published online Jan. 16 in the Proceedings of the ...
... By Steven Reinberg HealthDay Reporter , TUESDAY, ... to help most patients suffering from chronic obstructive pulmonary disease ... Emphysema and chronic bronchitis are the two main forms of ... hard for people to breathe. Since most COPD patients ...
... Mozes HealthDay Reporter , MONDAY, Jan. 16 (HealthDay ... significantly more likely to develop acne than their normal-weight peers, ... weight, and more specifically body mass index (BMI, a ratio ... of the common skin condition among teens. Teens, responses ...
Cached Medicine News:Health News:University of Granada researchers identify changes in tumor cells that lead to metastasis 2Health News:U-M News: Kidney failure risk higher for liver transplant patients following policy change 2Health News:Adolescents' brains respond differently than adults' when anticipating rewards 2Health News:Stanford computer algorithm used to identify bladder cancer marker 2Health News:Stanford computer algorithm used to identify bladder cancer marker 3Health News:Vitamin D Won't Help Most COPD Patients: Study 2Health News:Vitamin D Won't Help Most COPD Patients: Study 3Health News:Overweight Teen Girls May Have Higher Acne Risk 2Health News:Overweight Teen Girls May Have Higher Acne Risk 3
(Date:9/2/2014)... Mast Therapeutics, Inc . (NYSE MKT: MSTX) today announced that the ... at the Rodman and Renshaw 16 th Annual Global Investment ... in the Holmes II Salon at The New York Palace Hotel ... parties can access a live audio webcast and slide presentation on ... presentation will be available on the web site for 30 days. ...
(Date:9/2/2014)... SEATTLE , Sept. 2, 2014 /PRNewswire/ ... company committed to the development and commercialization ... today announced that the U.S. Food and ... designation to the investigation of motolimod (VTX-2337) ... doxorubicin (PLD) for the treatment of women ...
(Date:9/2/2014)... , September 2, 2014 , ... EMITF ) announced today following the Company,s ... Ltd. ("Elbit Medical") (TASE: EMTC-M), a subsidiary of the ... fully diluted basis, announced that on September 1, 2014 ... 30.8% of the voting power ("Gamida Cell") and vast ...
Breaking Medicine Technology:Mast Therapeutics To Present At The Rodman And Renshaw 16th Annual Global Investment Conference On September 9th 2Mast Therapeutics To Present At The Rodman And Renshaw 16th Annual Global Investment Conference On September 9th 3VentiRx Pharmaceuticals Announces Fast Track Designation Granted for Motolimod (VTX-2337), a Novel Immunotherapy for Women with Ovarian Cancer 2VentiRx Pharmaceuticals Announces Fast Track Designation Granted for Motolimod (VTX-2337), a Novel Immunotherapy for Women with Ovarian Cancer 3Elbit Imaging Announces Gamida Cell Closed Option and Investment Agreements with a Major Pharmaceutical Company 2Elbit Imaging Announces Gamida Cell Closed Option and Investment Agreements with a Major Pharmaceutical Company 3
... 2011 Eli Lilly and Company (NYSE: LLY ) ... on Monday, April 18, 2011.  Lilly will also conduct a conference ... further detail the company,s financial performance. The conference ...  Investors, media and the general public can access a live webcast ...
... 6, 2011 Pure Biomed LLC has launched a ... facial treatments for quick, temporary relief of nerve pain ... of nerve damage.  Reunion is the only full line ... Reunion products were developed from the ground ...
Cached Medicine Technology:Affordable Nerve Pain Treatment Now Available in the U.S. 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: