Navigation Links
BUSM researchers find anti-seizure drug may reduce alcohol consumption
Date:4/17/2014

BostonResearchers from Boston University School of Medicine (BUSM) have discovered that the anti-seizure drug ezogabine, reduced alcohol consumption in an experimental model. The findings, reported in the American Journal of Drug and Alcohol Abuse, may lead to more effective treatments for alcoholism.

Excessive consumption of alcohol is one of the leading causes of illness and death in the U.S. and has significant negative economic impact by limiting the productivity of workers and necessitating huge health care expenditures.

According to the researchers, this study provides the first evidence that alcoholism can be treated by this newly discovered mechanism that helps to regulate brain activity known as Kv7 channel modulation. "This finding is of importance because ezogabine acts by opening a particular type of potassium channel in the brain, called the Kv7 channel, which regulates activity in areas of the brain that are believed to regulate the rewarding effects of alcohol," explained lead author Clifford Knapp, PhD, associate professor of psychiatry at BUSM. "This research indicates that drugs that open Kv7 channels might be of value in the treatment of alcoholism," he added.

Previous studies conducted by this research group helped to establish the value of anti-seizure drugs as medications to treat alcoholism. However, further research needs to be conducted to establish that the effects of this drug result primarily from its actions on Kv7 channels. "Because of the close proximity of the doses at which ezogabine reduces drinking and those at which it is reported to produce motor impairment, it is still important to continue to investigate how selective the actions of ezogabine are on the neuronal mechanisms that control alcohol consumption," said Knapp.

The researchers believe these finding will encourage the search for other drugs that act on this system to discover more effective treatments for alcoholism.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers identify children with emotional behavior difficulties
2. Researchers identify similarities between HIV/AIDS and opioid addiction epidemics
3. Oxytocin, the love hormone, promotes group lying, according to Ben-Gurion U. researchers
4. Researchers develop device that simulates gastro-intestinal tract
5. UNC researchers show cancer chemotherapy accelerates molecular aging
6. NUS researchers developed worlds first fluorescent sensor to detect date rape drug
7. Cancer researchers find key protein link
8. Researchers: Biomarkers predict effectiveness of radiation treatments for cancer
9. Researchers issue state-of-the-state on genetic-based testing and treatment for breast cancer
10. Researchers identify impaired new learning in persons with Parkinsons disease
11. Researchers identify potential new therapeutic target for controlling high blood sugar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: