Navigation Links
BUSM investigates cellular mechanisms leading to immune response in airway epithelium
Date:11/23/2010

(Boston) Researchers from the Boston University School of Medicine (BUSM) have demonstrated that commensal species of the genus Neisseriae are low inducers of human airway epithelial cell responses as compared to the pathogenic species. Specifically, the study indicates that a Neisserial outer membrane component appears to play a differential role in the host inflammatory responses via interaction with a receptor on the surface of human airway epithelial cells.

Paola Massari, an assistant professor in the section of infectious diseases at BUSM, is lead author of this study, which is published in the Dec. 2010 issue of the journal Infection and Immunity.

The team focused their research on Neisseria lactamica, a gram negative organism comprising both commensal and pathogenic bacteria. Neisseria meningitidis, the causative agent of meningococcal meningitis, as well as Neisseria lactamica, colonize the human nasopharynx, but only Neisseria meningitidis is pathogenic.

"We set out to understand the relationship between commensal Neisseriae organisms and the human hosts," said Massari. "Although Neisseriae organisms express mostly identical surface antigens and structures, they appear to induce different responses when they interact with the host."

To examine how the bacteria interact with human nasopharyngeal cells, Massari and her research team honed in on a bacterial surface component, the PorB porin, present in all Neisseriae organisms. After purifying the PorB, they found that the protein from the commensal bacteria induced lower levels of human airway epithelial cell activation compared to PorB purified from the pathogenic organisms.

Next, the team demonstrated that PorB from N. lactamica and PorB from N. meningitidis appear to interact with the host cell surface receptor, Toll-like receptor 2 (TLR2), in a differential manner, thus leading to different inflammatory responses in human airway epithelial cells.

"This study confirms that TLR2 signaling is essential for the activation of human airway epithelial cells," said Massari. "This is likely one of the mechanisms by which the body limits inflammation in response to colonization with harmless commensal bacteria, thus avoiding exacerbation of inflammatory responses and local chronic local inflammation.


'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. UI study investigates variability in mens recall of sexual cues
2. Thesis investigates characteristics of society using sports activities as research tool
3. Food Safety Law Firm Investigates Major Outbreak of E. coli Linked To Lettuce
4. Long Island Press Investigates Big Tobacco's Lobby to Kill Indian Cigarette Trade
5. Positive psychological changes from meditation training linked to cellular health
6. c-Met may be a biomarker for metastatic hepatocellular carcinoma
7. A potential chemotherapeutic drug to treat hepatocellular carcinoma
8. Linc-ing a noncoding RNA to a central cellular pathway
9. Turning back the cellular clock
10. Cellular South Renews As Official Partner Of 2010 St. Jude Classic
11. Human Extracellular Matrix Significantly Improves Device Biocompatibility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... 04, 2016 , ... Are You Concerned About Mold In Your Home or ... Air Quality Companies in VA, MD and DC, recently completed its application for the ... mold law in the district of Columbia is a good thing stated John Taylor, ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... on the perils of heroin that was watched live by 1 million viewers ... I. duPont-Columbia University Award. , ASU students at the Walter Cronkite School of ...
(Date:12/2/2016)... CO (PRWEB) , ... December 02, 2016 , ... Advanced ... announced it has appointed Jason Bice, CPA, MBA to serve as Advanced Inc.’s Chief ... for Advanced, Inc. , Jason brings extensive financial and operational leadership experience to ...
(Date:12/2/2016)... , ... December 02, 2016 , ... U.S. Surgeon General, ... with Mediaplanet, Dr. Murthy explains how he was inspired to practice medicine at an ... that medicine is about more than making diagnoses and prescribing medicine,” he states. “It ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... More than ... and while 84 percent of parents report speaking with their child about sex related ... sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its second ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... WOONSOCKET, R.I. , Dec. 2, 2016 ... hold its annual Analyst Day in New York City on Thursday, December ... the CVS Health leadership team will provide an in-depth ... and enhance shareholder value. The company will also discuss ... audio and video webcast of the event will be ...
(Date:12/2/2016)... -- Orthopedic Implants (Including Spinal Implants, Reconstructive Joint ... a Significant Market Share Owing to a Large Global Baby ... ... According to a new report by Persistence Market Research ... Product Type Segment Projected to Witness a Significantly High CAGR ...
(Date:12/2/2016)... 2, 2016   CytoSorbents Corporation (NASDAQ: ... European Union approved CytoSorb ® cytokine adsorber to ... worldwide, announced that Dr. Phillip Chan , Chief ... LD Micro Main Event investor conference held from ... Luxe Sunset Boulevard Hotel in Los Angeles, ...
Breaking Medicine Technology: