Navigation Links
BUSM authors propose potential epigenetic mechanisms for improved cancer therapy
Date:2/19/2013

(Boston) A review article by researchers at Boston University School of Medicine (BUSM) proposes a new epigenetic hypothesis linked to tumor production and novel ideas about what causes progenitor cells to develop into cancer cells. Published in the February 2013 issue of Epigenomics, the article provides examples of how epigenetic drug treatments could be beneficial in treating cancers while also decreasing the likelihood of cancer relapse.

The article was written by researchers at the Boston University Cancer Center. Sibaji Sarkar, PhD, adjunct instructor of medicine at BUSM, is the article's corresponding author.

Cancer is a complex disease characterized by uncontrolled cell growth, division and invasion into other tissues. A 2004 review article published in Nature Medicine suggests that epigenetics, which is the phenomena whereby genetically identical cells express their genes differently resulting in different phenotypes and other factors play an important role in the formation of cancer originating from cancer stem cells.

Sarkar and colleagues propose that epigenetic processes, specifically DNA methylation, may trigger cancer progenitor cell formation from somatic cells in coordination with other cellular and environmental events. DNA methylation is a process that changes the DNA and causes genes to be silenced. In the absence of definitive proof of the existence of cancer stem cells, this hypothesis discusses a possible explanation for the formation and existence of cells that may develop into cancer. The researchers also explore why only some individuals develop cancer, despite identical genetic predispositions.

In cancer cells, the enzyme that maintains high levels of methylation in tumor suppressor genes is highly expressed, allowing uncontrolled growth. At the same time, many oncogenes, or genes with the potential to cause cancer, are activated and have lower levels of methylation. The apparent anomaly
'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jeffrey W. Olin, DO, authors study that describes symptoms and severity of fibromuscular dysplasia
2. Elsevier congratulates its British Medical Association award winning medical authors and editors
3. Authors of landmark study on infant mortality and electronic medical records receive Garfield Award
4. Dr. Marcelo Lancman, Medical Director of the Northeast Regional Epilepsy Group (NEREG) of New York and New Jersey Authors Book on New Epilepsy for Patients and Loved Ones
5. People can Achieve New Year’s Resolutions and Avoid Self-Sabotage -- so say Authors Tanya Chernova and Joanna Andros in UNDERMIND, from Indigo River Publishing
6. Holistic Family Doctor Authors Amazon Bestselling Book in Response to ObamaCare
7. IADR/AADR publish studies on severe early childhood caries - proposes new classification
8. Proposed testosterone testing of some female olympians challenged by Stanford scientists
9. EPA Proposes New Cuts on Levels of Soot in Air
10. Proposed drug may reverse Huntingtons disease symptoms
11. The hidden disorder: Unique treatment proposed for childrens neurological disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... Kan. (PRWEB) May 05, 2015 B. ... exclusively to healthcare providers, has been retained to recruit ... in Helena, Mont. The top executive search firm in ... more than 900 healthcare executives into organizations. , Shodair ... treatment facility in Montana to offer both acute and ...
(Date:5/5/2015)... DC (PRWEB) May 05, 2015 ... Plan Week, AIS’s Directory of Health Plans, and ... to announce its new monthly newsletter, AIS’s Value-Based ... health systems, physician groups, pharma companies and their ... organizations (ACOs), medical homes, bundled payments, coordinated care, ...
(Date:5/5/2015)... Ohio (PRWEB) May 05, 2015 ... ergonomic seating solutions, will feature models from its two ... at the Merchandise Mart in Chicago. Headlining the company’s ... from the MVMT™ seating line, as well as the ... BioFit™ Collection. Additionally, BioFit president Ed Metzger will deliver ...
(Date:5/5/2015)... “We currently have larger size casual sun hats that ... SunGrubbies.com. “We felt it was time to address the issue ... hat in an extra large size that they can wear to ... sun hats such as the Rebecca, Chloe, Stevie Fedora and ... an extra large size , fitting heads that measure up ...
(Date:5/5/2015)... No one cares about health problems until ... and Prevention cite multiple sources causing poor indoor air ... air quality (pollution) can bother your eyes, nose, and throat. ... and cancer.” , Toxic chemicals often get into the human ... water, or in some cases, absorb them through our skin. ...
Breaking Medicine News(10 mins):Health News:Shodair Children’s Hospital Retains B. E. Smith to Recruit New Administrator 2Health News:Shodair Children’s Hospital Retains B. E. Smith to Recruit New Administrator 3Health News:New AIS Newsletter Features Expert Insights and Strategies on Value-Based Care Arrangements 2Health News:BioFit to Introduce New Models from Latest Specialized Ergonomic Seating Lines at NeoCon 2015 2Health News:BioFit to Introduce New Models from Latest Specialized Ergonomic Seating Lines at NeoCon 2015 3Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Launches Their New Extra Large Size Fashion Sun Hats Collection 2Health News:revitaRUGS is Offering Area Rug Cleaning Discounts in Support of Asthma and Allergy Awareness Month This May 2Health News:revitaRUGS is Offering Area Rug Cleaning Discounts in Support of Asthma and Allergy Awareness Month This May 3
... since the mid-1950s particularly since tobacco-control policies and ... on Smoking and Health was released in 1964 ... 2000, according to a study led by researchers at ... Cancer Institute-funded study, conducted by a consortium of six ...
... , WEDNESDAY, March 14 (HealthDay News) -- ... States caused by imported food rose in recent years, ... at the U.S. Centers for Disease Control and Prevention ... Surveillance System between 2005 and 2010. During those five ...
... enough to depress anyone, but African-American men who believe ... emotional control experience more depression symptoms, according to new ... Hill. The study, "Taking It Like a Man: ... Symptoms Association Among African-American Men," was published online March ...
... Few people know about the participation of Brazil in Word ... conflict, it eventually sent a fleet to support the war ... country to do so. But the Brazilian expedition encountered an ... -like all other Armies- it was not prepared for: the ...
... Mo. Researchers estimate nearly 800,000 preventable adverse ... year. Many of these incidents could be prevented ... process in which health care professionals, such as ... identify and resolve discrepancies when patients transfer between ...
... professionals, patients and philosophers will come together at a special ... National Health Service. Among the questions for discussion will ... economy repairing citizens to make them fit for work? ... The NHS as ,Civil Association, is the spring conference of ...
Cached Medicine News:Health News:Study: US tobacco-control efforts prevented nearly 800,000 cancer deaths between 1975 and 2000 2Health News:Recent Rise Seen in Foodborne Diseases From Imports: CDC 2Health News:Hiding emotions may exacerbate depression among black men who confront racial discrimination 2Health News:The Brazilian Navy faces its worst enemy in WWI: The Spanish flu 2Health News:Increased collaboration between nursing home RNs and LPNs could improve patient care 2Health News:Conference explores ethical dimension of NHS 2
(Date:5/4/2015)... , May 4, 2015  BioSpecifics Technologies Corp. ... in class collagenase-based products marketed as XIAFLEX ® ... XIAPEX ®  in the EU, will announce its first ... U.S. financial markets on Monday, May 11, 2015 and ... a.m. ET the next day, Tuesday May 12, 2015.  ...
(Date:5/4/2015)... 2015 Microbrush International, a leading developer, producer ... restorative procedures, today announced the acquisition of DentiSmart ... sectional matrix system used in dental restorative procedures. ... opportunity to add DentiSmart to our growing portfolio ... VP and General Manager of Microbrush. "DentiSmart,s products ...
(Date:5/4/2015)... , May 4, 2015   The New York ... Kybella, from internationally acclaimed plastic surgeon, Dr. Rod ... Drug Administration, is proven to reduce fat deposits under ... The active ingredient in Kybella, deoxycholic ... plastic surgeons the ability to reshape this area without ...
Breaking Medicine Technology:BioSpecifics Technologies Corp. to Report First Quarter 2015 Financial Results on Monday, May 11, 2015 2Microbrush International Announces Acquisition of DentiSmart 2Dr. Rod Rohrich Provides Medical Expertise on Kybella 2Dr. Rod Rohrich Provides Medical Expertise on Kybella 3
... Dec. 7, 2010 LABS Inc., the premier transplant ... that Kevin M. Smith, Chief Operating Officer of the ... has joined the company,s Board of Directors.  Smith brings ... industries. In addition to his current role ...
... 80 percent of the surgeries performed in the U.S. put patients ... a brain monitor is not used by the anesthesiologist. ... book recently published by Dr. Barry Friedberg, an acclaimed anesthesiologist who ... in Michael Jackson,s death. "The simple use of a ...
Cached Medicine Technology:LABS Inc. Adds Life Sciences Industry Veteran Kevin M. Smith to Board of Directors 2Michael Jackson's Death Could Have Been Avoided With a Brain Monitor Says Anesthesiologist 2
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... The Eppendorf Reference Series 2000 Pipette ... smooth stroke, a compact and robust design, ... button is used to operate the measuring ... the tip. Product features:Eppendorf "pipette/tip" system ensures ...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Medicine Products: