Navigation Links
BUSM authors propose potential epigenetic mechanisms for improved cancer therapy
Date:2/19/2013

(Boston) A review article by researchers at Boston University School of Medicine (BUSM) proposes a new epigenetic hypothesis linked to tumor production and novel ideas about what causes progenitor cells to develop into cancer cells. Published in the February 2013 issue of Epigenomics, the article provides examples of how epigenetic drug treatments could be beneficial in treating cancers while also decreasing the likelihood of cancer relapse.

The article was written by researchers at the Boston University Cancer Center. Sibaji Sarkar, PhD, adjunct instructor of medicine at BUSM, is the article's corresponding author.

Cancer is a complex disease characterized by uncontrolled cell growth, division and invasion into other tissues. A 2004 review article published in Nature Medicine suggests that epigenetics, which is the phenomena whereby genetically identical cells express their genes differently resulting in different phenotypes and other factors play an important role in the formation of cancer originating from cancer stem cells.

Sarkar and colleagues propose that epigenetic processes, specifically DNA methylation, may trigger cancer progenitor cell formation from somatic cells in coordination with other cellular and environmental events. DNA methylation is a process that changes the DNA and causes genes to be silenced. In the absence of definitive proof of the existence of cancer stem cells, this hypothesis discusses a possible explanation for the formation and existence of cells that may develop into cancer. The researchers also explore why only some individuals develop cancer, despite identical genetic predispositions.

In cancer cells, the enzyme that maintains high levels of methylation in tumor suppressor genes is highly expressed, allowing uncontrolled growth. At the same time, many oncogenes, or genes with the potential to cause cancer, are activated and have lower levels of methylation. The apparent anomaly
'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jeffrey W. Olin, DO, authors study that describes symptoms and severity of fibromuscular dysplasia
2. Elsevier congratulates its British Medical Association award winning medical authors and editors
3. Authors of landmark study on infant mortality and electronic medical records receive Garfield Award
4. Dr. Marcelo Lancman, Medical Director of the Northeast Regional Epilepsy Group (NEREG) of New York and New Jersey Authors Book on New Epilepsy for Patients and Loved Ones
5. People can Achieve New Year’s Resolutions and Avoid Self-Sabotage -- so say Authors Tanya Chernova and Joanna Andros in UNDERMIND, from Indigo River Publishing
6. Holistic Family Doctor Authors Amazon Bestselling Book in Response to ObamaCare
7. IADR/AADR publish studies on severe early childhood caries - proposes new classification
8. Proposed testosterone testing of some female olympians challenged by Stanford scientists
9. EPA Proposes New Cuts on Levels of Soot in Air
10. Proposed drug may reverse Huntingtons disease symptoms
11. The hidden disorder: Unique treatment proposed for childrens neurological disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to ... it comes time to cook the next meal, making July the most appropriate to ... best grilling tips and recipes. , Make the next cookout different than the ones ...
(Date:7/31/2015)... Rolling Meadows, IL (PRWEB) , ... July 31, ... ... great ways to communicate. Rally Insurance Group, Inc. has re-branded their social media ... provides a personal way for consumers to communicate, find information, share insights ...
(Date:7/31/2015)... Washington, PA (PRWEB) , ... July 31, 2015 , ... ... specialties, is excited to launch three new Board Exam Courses. , The additions ... Smartest Doc Board Exam Prep from MDLinx makes preparing for the exam easy and ...
(Date:7/31/2015)... Los Angeles, CA (PRWEB) , ... July 31, 2015 , ... According to the ... the third floor of the Pasadena courthouse was contained and extinguished by the city’s fire ... one was in the building at the time of the fire, and it was a ...
(Date:7/31/2015)... ... 2015 , ... Well-known for its unique pastries and delicious confections, Pastry Palace, ... designs, making life just a little bit sweeter for newlyweds. A family-owned business, the ... orders one. , The bakery provides a full line of custom wedding cakes. Brides ...
Breaking Medicine News(10 mins):Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2
... small reduction in LDL cholesterol can contribute to far reaching ... to a US study, scientists have said that even a ... is amply found in the dairy products, meat and hydrogenated ... nearly 50%. ,The study on this subject was ...
... claim that more people could be at risk of ... previously thought after new evidence emerged that the condition ... to the scientists from Edinburgh a long incubation period ... blood transfusions and surgical instruments, can become a significant ...
... physicians who provide free care to the poor has ... becoming huge problem for America’s quickly growing number of ... conducted by the Center for Studying Health System Change, ... care in the mid-1990s, compared with about two-thirds now. ...
... patients who participated in a UC Davis study of ... blood pressure. // ,Conducted by UC Davis ... trial to assess the effect of grape seed extract ... factors that increase the risk for heart disease, including ...
... are well aware of Kawasaki as a motorcycle rather than ... doctors informed that his 9 year old daughter, Utkarsha was ... so as it is prevalent among Korean and Japanese children. ... that Kawasaki was a disease,' remarked Dinesh Ghai. ...
... world tuberculosis day. It was thought decades ago that the ... still remains a major // threat and its toll still ... rising at almost 1% every year despite the efforts taken ... globally in 2004 and infected nearly 9 million, according to ...
Cached Medicine News:Health News:Mad Cow Disease – Worst Is Yet To com 2Health News:Fewer Doctors Treating For Free 2Health News:High Blood Pressure Can Be Treated With Grape Seed Extract 2Health News:Low Awareness Of Kawasaki Disease In Capital: Parents Form Support Group 2Health News:Tuberculosis Is Still A Major Health Threat In Africa 2
(Date:7/31/2015)... India , July 31, 2015 ... CRM solutions for video, data and cloud computing ... with a leading pharma giant for Internet of ... different IoT applications offered on subscription model. ... Pharma giant is striving for business innovations ...
(Date:7/30/2015)... Calif. , July 30, 2015 IRIDEX ... will release its second quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
(Date:7/30/2015)... you a special edition of #MedicareMonday on Medicare,s 50 th anniversary. As Medicare ... and continue highlighting the success of the prescription drug benefit, commonly referred to as ... latest infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
Breaking Medicine Technology:Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3
... Takeda Global Research & Development Center, Inc., ... (FDA) has assigned a Prescription Drug User Fee Act ... review of its investigational type 2 diabetes therapy alogliptin, ... with pioglitazone in a single tablet.   ...
... its third annual Human Milk (breast milk) Collection Campaign in ... As part of the campaign, Medela will donate a total ... units across the country. "We want to do ... of human milk feeding -- to help protect premature babies ...
Cached Medicine Technology:Takeda Announces PDUFA Action Date for Investigational Type 2 Diabetes Therapies Alogliptin and the Fixed-Dose Combination Alogliptin/Pioglitazone 2Takeda Announces PDUFA Action Date for Investigational Type 2 Diabetes Therapies Alogliptin and the Fixed-Dose Combination Alogliptin/Pioglitazone 3Medela Announces Virtual Breast Milk Collection Campaign in Honor of Prematurity Awareness Month 2
300XL System, English (U.K. cord), 100-240 VAC....
Micro-mini fiber optic light....
Micro-mini fiber optic light....
The MC-3 allows for simultaneous use of two lamps, with an additional built-in spare....
Medicine Products: